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1996 Fiscal Year Final Research Report Summary

DETERMINATION OF A NEW CRITERIA FOR ORTHOSTATIC DYSREGUATION

Research Project

Project/Area Number 07670917
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionOSAKA MEDICAL COLLEGE

Principal Investigator

TANAKA Hidetaka  OSAKA MEDICAL COLLEGE ASSOC PROF, 医学部, 講師 (90188326)

Co-Investigator(Kenkyū-buntansha) TOKUDA Masakuni  OSAKA MEDICAL COLLEGE OVERLECUTRE, 医学部, 講師 (10227580)
KATAYAMA Hiroshi  OSAKA MEDICAL COLLEGE LECTURE, 医学部, 助手 (30194781)
Project Period (FY) 1995 – 1996
KeywordsOrthostatic dysregulation / Orthostatic test / Diagnostic criteria / orthostatic hypotenion / Adolescents / Orthostatic dizziness / FINAPRES / continuous blood pressure measurments
Research Abstract

We determined the criteria for instantaneous orthostatic hypotension (INOH), a typical form of orthostatic dysregulation, from the reference data of 173 healthy children, aged 6 to 18 years. Also reported were clinical characteristics, circulatory and catecholamine responses to postural change in 44 children and young adults with instantaneous orthostatic hypotension (INOH) compared with 73 age matched controls. The criteria for INOH was as follows : group I (mild type), a 60% or greater decrease in mean blood pressure during the initial phase of standing, or blood pressure recovery time of more than 25 sec evaluated by a non-invasive finger arterial pressure monitoring system ; group II (severe type), prolonged reduction in systolic arterial pressure of more than 15% during the later stage of standing in addition to the criteria for group I.Sensitivity and specificity of this criteria were as high as 100% and 90.4%, respectively. Group I and group II showed significantly more pronounc … More ed reduction in BP) than normal controls at the initial drop (% reduction for systolic BP : -53+-12, -50+-6 vs.-32+-16, respectively, p<0.001), one minute of standing (-6+-10, -24+-18 vs.6+-12, p<0.001) and five minute of standing (-5+13, -21+-11 vs.8+-9, p<0.05). Plasma noradrenaline responses to standing were significantly lower in group I and group II than in controls after one minute of standing (50+-63,33+-39 vs.99+-56 pg/ml, respevtively), and were kept lower in group II after five minutes (218+-122,115+-78 vs.193+-98 pg/ml, respectively). The physical complaints included chronic fatigue (91% of the patients), orthostatic dizziness (88%), weakness (84%), sleep disturbance (73%), syncope or near syncope (68%), headache (68%), loss of apprtite (57%), abdominal pain (55%). Among these complaints chronic fatigue, loss of appetite, orthostatic dizziness, syncope and morning tiredness were specific for INOH.These results suggest that mechanisms responsible for INOH may depend on reduced noradrenaline secretion during orthostatic stress, associated with centrally mediated sympathetic inhibition. The patients in group II seemed to have more decreased sympathetic activation and thus more impaired quality of life than those in group I including school absenteeism. INOH is an important pathological condition in children with complaints of orthostatic intolerance and chronic fatigue. This can be identified when using a non-invasive beat-to-beat continuous blood pressure monitoring system. Less

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Yamaguchi, H.et al.: "Beat-to-beat blood pressure and heart rate responses to active standing in Japanese children" Acta Paediatrica. 85. 577-583 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山口 仁, 田中 英高: "なぜ思春期に起立性調節障害が多くなるのか?" 自律神経. 33. 496-502 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanaka, H., et al.: "Treatment of orthostatic intolerance with inflatable abdominal band" The Lancet. 349. 175 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanaka, H., et al.: "The effects of noradrenaline precursor,L-Threo-3,4-dihydroxy-phenylserine,in children with orthostatic intolerance" Clinical Autonomic Research. 6. 189-193 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanaka, H., et al.: "Haemodynamic changes during vasodepressor syncope in children and autonomic function" Clinical Physiology. 17. 121-133 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamaguchi H,Tanaka H,Mino M: "Beat-to-beat Blood Pressure and Heart Rate Responses to Active Standing in Japanese Children" Acta Paediatr. 85. 577-83 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamaguchi H,Tanaka H: "Evidence of susceptibility to orthostatic dysregulation in pubertal children" JIRITSUSINKEI. 33. 496-502 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka H,Yamaguchi H,Tamai H: "Treatment of orthostatic intolerance with inflatable abdominal band" Lancet. 349. 175 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka H,Yamaguchi H,Mino M: "The effects of the noradrenaline precusor, L-threo-3,4-dihydroxyphenylserine, in children with orthostatic intolerance" Clin Autonom Res. 6. 189-193 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka H,Yamaguchi H,Tamai H,Mino M,Thulesius O: "Haemodynamic Changes during Vasodepressor Syncope ion Children and Relevant Autonomic Function" Clin Physiol. 17. 121-133 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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