1997 Fiscal Year Final Research Report Summary
Research of new photodynamic therapy to skin cancer
| Project/Area Number |
07670935
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Fukui Medical University |
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Principal Investigator |
ISHIGURO Kazumori Fukui Medical University, Dermatology, Assistant Professor, 医学部附属病院, 講師 (00222985)
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| Project Period (FY) |
1995 – 1997
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| Keywords | skin cancer / photodynamic therapy |
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| Research Abstract |
We need a new treatment of skin cancer with less side effect from a point of view of quality of life. Photodynamic therapy (PDT) has less side effect because of selective therapy of cancer cells.
First, the typical apoptotic phenomena in the L5178Y and HL-60 leukemia cells were observed by a fluorescence microphotometer, a TUNEL technique and the endonucleosomal cleavage with in 30min after laser irradiation. There was no signal of the endonucleosomal DNA cleavage in HMF melanoma cell. It was concluded that apoptotic cell death was dependent on the cell line even though the cells were treated by PDT in the same manner.
The second, the transplanted squamous cell carcinomas on C3H/He mice were irradiated by a tunable optical parametric oscillator laser light, in the presence of several different photosensitizers. After PDT,the tumor size were measured. In the results, it was observed good anti-tumor effect in order of PH-1126>ALPcS4>Pf-II>5-ALA>ATX-70.
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Research Products
(12 results)
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[Publications] Miyoshi, N., Karaya, K., Zhao-hui Jin, Ishiguro, K., Ueda, K., Fukuda, M.: "INCORPORATION OF 5-ALA (5-AMINOLEVULINIC ACID) IN CULTIVATED CANCER CELLS AND APOPTOSIS CELL DEATH BY PHOTOSENSITIZATION OF THE ENDOGENOUSL Y-PRODUCED P_P-IX." Photomedicine and Photobiology. 18. 83-84 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Zhao-hui Jin, Miyoshi, N., Ishiguro, K., Takaoka, K., Ueda, K., Fukuda, M.: "TREATMENT EFFECTS OF TRANSPLANTED SQUANOUS CELL CARCINOMA BY IRRADIATIONS OF LASERLIGHT OR ULTRASOUND WITH ENDOGENOUSLY-PRODUCED P_P-IX FROM HAEM PRECURSOR 5-ALA (5-AMINO-LEVULINIC ACID)." Photomedicine and Photobiology. 18. 85-86 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Zhao-hui Jin, Miyoshi, N., Ishiguro, K., Maruyama, I.Sakata, I.Takaoka, K.Udagawa, T.Nakazima, S.Ueda, K.Fukuda, M.Kumakiri, M.: "Combined Effects of Photodynamic and Sonodynamic Treatment on Experimental Skin Cancer on C3H Mice." Photomedicine and Photobiology. 19. 65-68 (1997)
Description
「研究成果報告書概要(欧文)」より
