1996 Fiscal Year Final Research Report Summary
Analysis of autoantibody induced by metal antigens
| Project/Area Number |
07670959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Yokohama City University |
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Principal Investigator |
ISHII Norihisa YOKOHAMA CITY UNIVERSITY,SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (50159670)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Autoantibody / Delayd-type hypersensitivity (DTH) / Genetic control / Gold / Major histocompatibility complex (MHC) / Mercury / Metal antigen / Mouse |
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| Research Abstract |
The genetic control of delayd-type hypersensitivity (DTH) to both gold (I) and gold (III) antigens was investigated in various strains of mice. Most mouse strains, with the exception of those with the major histocompatibility complex I-A^b allele, showed a marked DTH response to each antigen ; the magnitude of the response to gold (III) was greater than that of the response to gold (I). Moreover, the high responsive trait was dominant. The DTH footpad response was mediated by CD4^+8^-, Ia^-T cells.However, CD8^+T cells did not suppress footpad swelling. These results indicate that gold (I) and gold (III) can both stimulate a DTH response in mice.
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