1996 Fiscal Year Final Research Report Summary
Immunohistochemical and mollecular biological study on apoptosis in systemic scleroderma.
| Project/Area Number |
07670961
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Dokkyo University School of Medicine |
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Principal Investigator |
YAMAKAGE Akio Dokkyo Univ.Schl.of Med., Dermatology, Assoc.Prof., 医学部, 助教授 (50106944)
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| Co-Investigator(Kenkyū-buntansha) |
OHTSUKA Shun Dokkyo Univ.Schl.of Med., Dermatology, Instructor, 医学部, 助手 (10241879)
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| Project Period (FY) |
1995 – 1996
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| Keywords | apoptpsis / p53 / Fas / scleroderma / myc / bc1-2 / fibrosis / pigmentation |
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| Research Abstract |
We found tight connection between apoptosis and pathogenesis of systemic scleroderma. In epidermis of scleroderma, there were many fluorescent by TUNEL method suggesting that apoptosis playd an important role on pathogenesis of scleroderma. Phosphorylated nucleoprotein p53, cell surface molecule Fas, TNF receptor, oncogene myc, bc1-2, and CD40were located on epidrermis of scleroderma. We estimated that the expression rate of Fas and Fas ligand on the surface of lymphocytes from the patients were increased compared with normal controls by the method of FACS.
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