1996 Fiscal Year Final Research Report Summary
PRELIMINARY EVALUATION FOR USEFULNESS OF MR LYMPHOGRAPHY
| Project/Area Number |
07671026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | KEIO UNIVERSITY |
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Principal Investigator |
TANIMOTO Akihiro KEIO UNIVERSITY RADIOLOGY INSTRUCTOR, 医学部, 助手 (10171860)
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| Project Period (FY) |
1995 – 1996
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| Keywords | MRI / LYMPHOGRAPHY / CONTRAST MEDIA / IRON |
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| Research Abstract |
An ultrasmall superparamagnetic iron oxide preparation (AMI-227) was evaluated as a potential intravenous contrast agent for MR lymphogaphy. MR imaging and histopathologic examination were performed in rats with hyperplastic lymph nodes. To determine the optimal dose, 30-120 mum ol Fe/kg of AMI-227 was injected to animals with hyperplastic lymph nodes. MR signal intensity of lymph node sufficiently decreased 24 hours after intravenous administration of AMI-227 at the dose of 40 mu mol Fe/kg. Iron stain sections revealed the phagocytosed iron oxide particles in hyperplastic nodes. This result suggests that normal or hyperplastic nodes can be demonstrated as decreased signal intensity and be delineated from nodal metastases which do not show phagocytic activity. A model of nodal metastasis will be soon available and the usefulness of MR lymphography will be confirmed.
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