1996 Fiscal Year Final Research Report Summary
Brain imaging analysis of a mental-illness model animal with stress-vulnerability.
| Project/Area Number |
07671047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Gunma University |
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Principal Investigator |
IDA Iturou Gunma University School of Medicine, Department of Neuropsychiatry, Assistant, 医学部・神経精神医学講座, 助手 (50251103)
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| Co-Investigator(Kenkyū-buntansha) |
ENDOU Keigo Gunma University School of Medicine, Department of Nuclear Medicine and Diagnost, 医学部・核医学講座, 教授 (10115800)
MIKUNI Masahiko Gunma University School of Medicine, Department of Neuropsychiatry, Associate Pr, 医学部・神経精神医学講座, 助教授 (90060508)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Mood Disorder / Anxiety Disorder / Central Benzodiazepine Receptor / SPECT / Autoradiography |
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| Research Abstract |
1231-lomazenil (IMZ), a newly developed radioligand for single photon emission computed tomography (SPECT) which acts on benzodiazepine (BZD) receptors as a inverse agonist with high specific affinity, allows the in vivo study of the central BZD receptor functions. In 5 patients with anxiety disorders, the binding potential (BP) of BZD receptors was determined in several brain regions using the Table look-up procedure. As compared with 4 epileptic controls, the mean BP in 5 anxiety disorders patients was significantly decreased in the frontal, temporal, parietal and occipital cortex. Moreover, a significant correlation was observed between the total score on Hamilton rating scale of anxiety and the BP values in 2 regions, right temporal and left superior frontal cortex, suggesting that these regions associate with the alteration of anxiety level. On the other hand, we previously observed that prenatal stressful stimulation altered neurochemical, neurophysiological and neuroendocr inological function in the offspring. Thus, this prenatal stress model may have a face varidity as an animal model of mental illness, such as mood disorder and anxiety disorder. To investigate effects of stressful stimulation on the binding capacity of BZD receptors in this model animal, we conducted 1251-IMZ autoradiography when the offspring was exposed to acute immobilization stress. The binding capacity of BZD receptors in frontal cortex of the offspring tended to increase, but not significantly. This result suggested that prenatal stress exposure alters the anxiety-associated function of BDZ receptors.
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