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1997 Fiscal Year Final Research Report Summary

abnormal cytoskeleton in grial cells

Research Project

Project/Area Number 07671050
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Tokyo

Principal Investigator

AMANO Naoji  University of Tokyo, Department of psycheiatry, lecturer, 医学部・付属病院, 講師 (10145691)

Project Period (FY) 1995 – 1997
Keywordsprogressiue supra-nuclear palsy / corticobasal degeneration / abnormal grial cytoskeleton / argyrophilic inclusions / tuft-shaped astrocytes / glial coiled bodies / argyrophilic threads / astrocytic plaques
Research Abstract

1. Neuronal degeneration was investigated in twelve autopsy cases with progressive supranuclear palsy (PSP). Neuronal loss, fibrillary gliosis and Alzheimer's neurofibrillary tangles (NFTs) were evaluated in each brain. The globus pallidum, thalamus, subthalamic nucleus, hypothalamus, substantia nigra, periaqueductal gray matter, tegmentum of brain stem, inferior olivary nucleus and the dentate nucleus of cerebellum were highly degenerated. The white matter, especially in the frontal lobes, revealed loosening and mild fibrillary gliosis. Abnormal astrocytosis and neuronal loss of deep layers in the precentral and premotor cortices was demonstrated in 6 cases.
2. Argyrophilic inclusions stained with Gallyas-Braak's method were investigated in all the brains. Glial argyrophilic components were divided into three types of tuft-shaped astrocytes (TuSAs), glial coiled bodies (GCBs) and argyrophiic threads (ATs). These structures were distributed in the above-mentioned lesions, and also in th … More e white matter and cerebral cortex of precentral and premotor areas. The low amount of argyrophilic inclusions was observed in the temporal lobes. TuSAs were seen only in the gray matters of cerebral cortex and subcortical nuclei. GCBs and ATs were seen in both gray and white matters.
3. The immunohistochemical properties of glial argyrophilic granules were investigated in anti-tau protein antibody, anti-paired helical filaments (PHFs) antibody, anti-ubiquitin antibody, anti-microtubules-associated proteins antibodi and so on. The result was that they were stained strongly tau-positive, weakly ubiquitin- and PHE-positive, and negative in the other stainings.
4. The ultrastructural observation revealed that there were 15 nm straight tubules of NFTs in the sub cortical neurons, and that there was no abnormal accumulation in glial cytoskeletons of astrocytes and oligodendrocytes. It suggested that the similar phenomenon to "pretangle" of NIFTs might be occurred in glial cells.
5. Three autopsy cases with corticobasal degeneration were investigated in similar aspects. TuSAs were not observed, and astrocytic plaques were characteristic in the brains of CBD.GCBs and ATs were abundantly observed in CBD, and rarely in Pick's disease. The two diseases of PSP and CBD were comparatively investigated in the clinicopathological points. Less

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Amano N: "abnormal glial cytoskeleton for in progressi ue supraucclear paloy" Neuropathology. 16. 139-144 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Amano N, Takahashi T: "Clinical as pects on progress ue suprauucleal paloy" Neuropathology. 16. 239-245 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 池田研二,天野直二: "progresssive supranucleapalsyとcorticobasal degeneration -両疾患の異同と痴呆の責任病巣-" 病理と臨床. 14. 997-1002 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hanihara T,Amano N: "Distribution of tangles and threads in the cerelnal cortex of in prog ressn ue supranuclear paloy" Neuropathol Appe neurobiol. 21. 319-326 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi T, Amano N: "Corticobasal degeneration: widespread argentophieic threads and glia in addition to neuro fi brillay tangles" J. Neurol Sci. 138. 66-77 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Komori,Amano N et al.: "Morphologic difference of neuropil threads in Alzheimers disease , corticobasal degeneration and progressive supranuclear palsy a morphometric study" Neurosci Lett. 233. 89-92 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 天野 直二: "臨床精神医学講座10, 器算症状性精神障害進行性核上麻痺" 中山書店, 17 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 天野 直二: "精神科ケースライブラリーV 脳疾患による精神障害 大脳病変を伴った進行性核上麻痺" 中山書店, 14 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Amano N: "Progressive supranuclear palsy." Japanese Journal of Geriatric Psychiatry. 6. 1365-1372 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hanihara T., Amano N., Takahashi H.et al.: "Distribution of tangles and threads in the cerebral cortex in progressive supraneclear palsy." Neuropathol Appl Neurobiol. 21. 319-326 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Amano N., Takahashi T., Yagishita S.et al.: "Abnormal glial cytoskeleton in progressive supranuclear palsy." Neuropathology. 16. 139-144 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Amano N., Takahashi T.: "Clinical aspects on progressive supranuclear palsy." Neuropathology. 16. 239-245 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikeda K,Amano N: "progressive supranuclear palsy and corticobasal degeneration-The difference and the lesions of dementia in two dieases-" Byori to Rinsho (Japanese). 14. 997-1002 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi T., Amano N., Hanihara T.et al.: "Corticobasal degeneration : widespread argentophilic threads and glia in addition to neurofibrillary tangles. Similarities of cytoskeletal abnormalities in corticobasal degeneration and progressive supranuclear palsy." J Neurol Sci. 138. 66-77 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Komori, Amano N et al: "Morphologic difference of neuropil threads in Alzheimer disease, corticobasal degeneration and progressive supra-nuclear palsy." Neurosci Lett. 233. 89-92 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hanihara T,Amano N et al.: "Hypertrophy of the inferior olivary nucleus in patients with progressive supranuclear palsy." European Neurology. 39. 97-102 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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