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1996 Fiscal Year Final Research Report Summary

RESEARCH ON PSYCHIATRIC DISEASE AND TRINUCLEOTIDE REPEATS.

Research Project

Project/Area Number 07671084
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionSAITAMA MEDICAL SCHOOL

Principal Investigator

IKEDA Masaaki  SAITAMA MEDICAL SCHOOL,DEPARTMENT OF PHYSIOLOGY,ASSISTANT PROFESSOR, 医学部, 助手 (80232198)

Co-Investigator(Kenkyū-buntansha) YOSHIMURA Kazunori  SAITAMA MEDICAL SCHOOL,DEPARTMENT OF PHYSIOLOGY,ASSISTANT PROFESSOR, 医学部, 助手 (20158497)
Project Period (FY) 1995 – 1996
KeywordsTRIPLET REPEAT / CLONING / NEUROPSYCHIATRIC DISEASE / ANTICIPATION / PCR / REARRANGEMENT / MJD / SPLICE VARIANT
Research Abstract

1.Cloning and characterization of MJDl splice variants.
(1) . We cloned two splice variants of MJD1 gene mRNA from human lymphocytes. These are novel MJD1 mRNA variants that has not been previously described.
(2) . An alternatively spliced variant MJD1d contains an 54 bp insert just before the CAG repeat.
(3 ). An alternatively spliced variant MJD1e contains an 87 bp insert having a termination codon in frame.
2. Molecular cloning of triplet repeats containing cDNA fragment associated with neuropsychiatric diseases.
Several cDNA fragments containing triplet repeats were isolated from cerebral cortex. DNA sequencing and computer data base searches of GenBank demonstrated that these clones were novel molecules.
3. Characterization of triplet repeats containing gene products.
Establishment of the two-hybrid system that would be utilized to characterize the interaction between CAPDH or Hap-1 and triplet repeats containing gene products.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Kaneko A: "A case of Machado-Joseph disease presenting with spastic paraparesis." J Neurol Neurosurg Psychiatry. 62. 542-543 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneko A,Narabayashi Y,Itokawa K,Nakazato Y,Hosokawa T,Iwasaki S,Ohano R,Hamaguchi K,lkeda M,Nomura M.: "A case of Machado-Joseph disease presenting with spastic paraparesis." J Neurol Neurosurg Psychiatry. 62 (5). 542-543 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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