1996 Fiscal Year Final Research Report Summary
Basic and clinical studies for Alzheimer's disease and advanced glycation end products
| Project/Area Number |
07671097
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内分泌・代謝学
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| Research Institution | Hokkaido University |
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Principal Investigator |
MAKITA Zenji Hokkaido University, Hokkaido University Medical Hospital, Lecturer, 医学部・附属病院, 講師 (50261285)
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| Project Period (FY) |
1995 – 1996
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| Keywords | ALZHEIMER'S DISEASE / DIABETES MELLITUS / PATHOLOGY |
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| Research Abstract |
We developed a novel polyclonal antibody against advanced glycation end products (AGEs) in 1995. By using the antibody, we studied the immunohistochemical analysis in the brain tissue of Alzheimer's disease, and its related disorders. Also, we examined the therapeutic effects for diabetic nephropathy by a newly developed AGE inhibitor.
In summary
1) By using AGE antibody, we developed an ELISA for the measurement of AGE,and immunohistochemical technique for the detection of AGE accumulation in vivo.
2) We demonstrated that AGEs had oxic effects.
3) AGEs accumulated the brain tissue in Alzheimer's disease, Pick's disease, progressive supranuclear palsy, and Parkinsonism-dementia complex of Guam.
4) In Alzheimer's disease, AGEs accumulation occurred in the core of senile plaques.
5) A novel AGE inhibitor prevented the progression of diabetic nephropathy.
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