1996 Fiscal Year Final Research Report Summary
Recycling of glucose transporter and insulin action
| Project/Area Number |
07671106
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
内分泌・代謝学
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
SHIBATA Hiroshi Institute for Molecular and Cellular Regulation, Department of Cell Biology, Gunma University, Associate Professor, 生体調節研究所, 助教授 (20235584)
|
|---|
| Project Period (FY) |
1995 – 1996
|
| Keywords | insulin / glucose transporter / GTP-binding protein / Rab4 |
|---|
| Research Abstract |
GTP-binding proteins regulate both exocytotic and endocytotic steps of GLUT4-containing vesicles in rat adipocytes. In the present study, we have shown that a synthetic peptide corresponding to the Rab4 carboxy-terminal domain inhibits insulin-induced GLUT4 translocation, indicating that Rab4 may be essential for the insulin action. Furthemore, insulin stimulated guanine nucleotide exchange on Rab4. This insulin action was markedly attenuated with phosphatidylinositol (Pl) 3-kinase inhibitors, wortmannin or LY294002, suggesting that Pl3-kinase may be an essential signaling component for insulin activation of Rab4.
|
Research Products
(9 results)
