1996 Fiscal Year Final Research Report Summary
Patency after vascular anastomosis in diabetic critically ischemic limb
| Project/Area Number |
07671293
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | UNIVERSITY OF TOKYO |
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Principal Investigator |
ARAMOTO Haruo University of Tokyo, Surgery, Assistant, 医学部・附属病院, 助手 (30281702)
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| Co-Investigator(Kenkyū-buntansha) |
KOMIYAMA Takashi University of Tokyo, Surgery, Assistant, 医学部・附属病院, 医員
YASUHARA Hiroshi University of Tokyo, Surgery, Lecturer, 医学部・附属病院, 講師 (50251252)
SHIGEMATSU Hiroshi University of Tokyo, Surgery, Lecturer, 医学部・附属病院, 講師 (40134556)
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| Project Period (FY) |
1995 – 1996
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| Keywords | critical limb ischemia / diabetes / anastomotic intimal hyperplasia / vascular graft |
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| Research Abstract |
With NZW-rabbit, after severely poor run-off (bilateral iliac arteries ligation) and artificial graft reconstruction surgery, we encounterd many early deaths owing to early graft occlusion. For long-term observation, we had to find the toleratedly reduced run-off models. We compared different poor run-off states in 4 groups ; unilateral femoral artery ligation (A), bilateral femoral arteries ligation (B), unilateral femoral+contra-lateral iliac arteries ligation (C) and bilateral iliac arteries ligation with autovein graft reconstruction for long-term patency. Since, group A developed only slight run-off reduction, and in group C and D,we recognized almost as many deaths as severely poor run-off models, we selected group B as the best model.
B)Hemodynamic change between two-stage operations
Even though group B model appeared the best model, we had to add two stage surgery for long survival. In 1 week interval model, there was still high prevalence of early deaths. In 2 or 4 weeks interval models the early deaths enough reduced but unexpected development of collateral pathways was recognized as the interval became longer. We concluded the best interval for 2 stage surgery was 2 weeks.
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