1996 Fiscal Year Final Research Report Summary
Intraperitoneal Administration of alpha-Tricalcium Phosphate (alpha-TCP) Particles as a Drug Carrier in Rats Bearing Abdominal Carcinomatosis for the Purpose of the Clinical Application
| Project/Area Number |
07671318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
MANABE Tadao Nagoya City University Medical School, Professor, 医学部, 教授 (80127141)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUNO Isamu Nagoya City University, Medical School, Lecturer, 医学部, 講師 (20157506)
YOTSUYANAGI Toshihisa Nagoya City University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (40080189)
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| Project Period (FY) |
1995 – 1996
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| Keywords | carboplatin / alpha-TCP-particles / AH130 carcinoma / controlled release |
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| Research Abstract |
alpha-Tricalcium phosphate (alpha-TCP) is biomaterial and its chemical properties is as similar as hydroxyapatite. It is known that alpha-TCP has excellent compatibility with human tissues and is biodegradable. We usesd alpha-TCP particles as a drug carrier, mixing with 4mg carboplatin (CBDCA) to 200mg alpha-TCP particles, and made the slow relesae drugs : alpha-TCP-CBDCA.
The pharmacokinetics of alpha-TCP-CBDCA were examined using Donryu rat models with AH130 abdominal carcinomatosis. alpha-TCP particles were administered into the peritoneal cavity (i.p.) and were taken up especially in the greater omentum. The Pt levels in ascites and the greater omentum were higher in the alpha-TCP-CBDCA i.p. from 1 to 168 hours than in the CBDCA i.p. and i.v. groups.
alpha-TCP-CBDCA i.p. was effective in prolonging the survival of rats. These results suggest that the efficacy of CBDCA may be enhanced by utilizing alpha-TCP particles as a drug carrier.
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Research Products
(13 results)
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[Publications] ISAMU MIZUNO,TETSUYA YAMAMOTO,TOSHIHISA YOTSUYANAGI,YOSHIMI AKAMO,TATSUO ICHINO,TAMOTSU YASUI,KENJI KOBAYASHI,MASATETSU TANIGUCHI,MARIKO NAGATA,JIRO YURA,SATOSHI NAKAMURA and HIDEKI AOKI: "Intraperitoneal administration of lentinan-loaded hydroxyapatite particles as a drug carrier in rats bearing carcinomatous peritonitis." Artif.Organs Today.vol.3. 185-192 (1994)
Description
「研究成果報告書概要(欧文)」より
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[Publications] N.MOHRI,I.MIZUNO,T.MANABE,J.TERADA,Y.AKAMO,T.YAMAMOTO,K.KOBAYASHI,T.YOTSUYANAGI,M.NAGATA,H.AOKI,and S.NAKAMURA: "Intraperitoneal administration of carboplatin-loaded hydroxyapatite particles in rats bearing AH130 carcinomatous peritonitis" 1st International Gastric Cancer Congress. 1647-1651 (1995)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Isamu Mizuno^<**1>, Tamotsu Yasui^<**1>, Hiromitsu Takeyama^<**1>, Masakazu Ishikawa^<**1>, Junji Terada^<**1>, Noriaki Mohri^<**1>, Takuya Ueda^<**1>, Naoki Sumita^<**1>, Kenji Kobayashi^<**1>, Yoshimi Akamo^<**1>, Tadao Manabe^<**1>, Toshihisa Yotsuyanagi^<**2> and Hiroshi Mizuno^<**3>: "ANTITUMOR FFFECTS OF LIPOSOME-ENTRAPPED CARBOPLATIN (LIPO-CBDCA) AFTER INTRAPERITONEAL ADMINISTRATION IN RATS BEARING CARCINOMATOUS PERITONITIS" Jpn J Cancer Chemother. 22 (11). 1598-1601 (1995)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Takuya UEDA,Isamu MIZUNO,Toshihisa YOTSUYANAGI,Yoshimi AKAMO,Noriaki MOHRI,Tadashi SHIBATA,Junji TERADA,Hiromitsu TAKAYAMA,Tadao MANABE,Mariko NAGATA,Satoshi NAKAMURA,Hideki AOKI: Intraperitoneal administration of alpha-Tricalcium phosphate (alpha-TCP) particles as a drug carrier in rats bearing abdominal carcinomatosis for the purpose of the clinical application. 2nd International Gastric Cancer Congress (in press), (1997)
Description
「研究成果報告書概要(欧文)」より
