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1996 Fiscal Year Final Research Report Summary

INNERVATION OF THE BILIARY DUCTS IN HUMANS,PIGS,MONKEYS,DOGS AND HUMSTERS.

Research Project

Project/Area Number 07671385
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionShiga University of Medical Science

Principal Investigator

KINOSHITA Takashi  Shiga University of Medical Science Second Department of Surgery Assistant Professor, 医学部, 助手 (50263041)

Co-Investigator(Kenkyū-buntansha) FUJIMURA Masaki  SHiga University of Medical Science Second Department of Surgery Associate Profe, 医学部, 助教授 (50115771)
Project Period (FY) 1995 – 1996
Keywordsbiliary ducts / nitric oxide synthase / NADPH-diaphorase / protein gene product 9.5 / vasoactive intestinal peptide / neuropeptide Y / histochemistry
Research Abstract

The autonomic nervous system appears to play an important role in the biliary ducts, as well as in the digestive tract. In this study, the distribution of nerves in various parts of the biliary ducts were examined in detail using immunohistochemistry and enzymehistochemistry in humans, pigs, monkeys, dogs and humsters. Numerous immunoreactive nerves were seen with antisera against peripheral nerve markers (protein gene product 9.5). These nerves were observed everywhere in the biliary ducts including the hepatic ducts, common bile duct, gallbladder, cystic duct, and the sphincter of the duodenal papilla. In the biliary ducts, acetylcholinesterase (AChE) positive nerve fibers, nitric oxide synthase (NOS) containing nerve fibers, and 5 types of peptidergic nerve fibers including neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP) and enkephalin (EK) were detected. AChE positive nerve fibers, NOS containing nerve fibers and NPY-immunoreactive nerve fibers were abundant, but the other nerve fibers were scarce. Further more, AChE positive nerve cells and NOS containing nerve colls were scattered throughout the biliary ducts. The result of this study suggests that various types of nerves mediate the maintenance of functional states in the biliary ducts, including the transport, storage and excretion of bile juice.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Takashi Kinoshita.: "Histochemical localization of nitric oxide synthase in mouse biliary ducts." Biomedical Research. 15(supple,2). 187-193 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤村 昌樹: "肝内結石症における神経分布について." 厚生省特定疾患肝内結石症調査研究班平成5年度研究報告書. 49-51 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤村 昌樹: "ハムスター胆管神経破壊モデルを用いた胆石形成実験について." 厚生省特定疾患肝内結石症調査研究班平成6年度研究報告書. 88-90 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中島 恭二: "総胆管神経におけるNADPH-diahorase組織化学" 消化管ホルモン. 47-51 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田野辺 裕二: "イヌOddi括約筋における非アドレナリン性抑制性神経の化学伝達物質が一酸化窒素である可能性について." 消化管ホルモン. 183-185 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤村 昌樹: "肝内結石症における神経分布について." 厚生省特定疾患肝内結石症調査研究班平成7年度研究報告書. 61-66 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木下 隆: "肝臓病学" 肝臓の神経支配(発表予定),

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Kinoshita, Masaki Fujimura, HIroshi Kimura.: "Histochemical localization of nitric oxide synthase in mouse biliary dycts" Biomedical Research. 15(supple.2). 187-193 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kyoji Nakajima, Masaki Fujimura, Takashi Kinoshita, Ikuo Yamamoto, Hiroshi Yamamoto, Wei-Guang Ding.: "Histochemical study of NADPH-diahorase in the nerves of common bile duct" Gut Hormon. 47-51 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuji Tanobe, Tomio Okamura, Noboru Toda, Takashi Kinoshita, Masaki Fujimura.: "Role of nitric oxide as a putative transmitter of non-adrenergic inhibitory nerve in isolated canine sphincter of Oddi" Gut Hormon. 183-185 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuji Tanobe, Tomio Okamura, Masaki Fujimura, Noboru Toda.: "Function role and histrogical demonstration of nitric-oxide-mediated inhibitory nerves in dog sphincter of Oddi" Neurogastroenterology and Motility. 7. 219-227 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Kinoshita, Masaki Fujimura: "Innervation of the liver" Igakushoin. Basic Hepatology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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