1996 Fiscal Year Final Research Report Summary
Analysis of malignant biology and gene disorder in gastric MALT lymphomas
| Project/Area Number |
07671404
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
SATOH Hiroshi Kyushu Univ.Fac.Med assistant prof., 医学部, 助手 (40196267)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kenjiro Kyushu Univ.Fac.Med assistant prof., 医学部, 助手 (30207873)
MIZUMOTO Kazuhiro Kyushu Univ.Fac.Med assistant prof., 医学部, 助手 (90253418)
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| Project Period (FY) |
1995 – 1996
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| Keywords | gastric malignant lymphoma / MALT lymphoma / surgical treatment / total gastrectomy / lymph node dissection / Helicobacter pylori |
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| Research Abstract |
Since new entity of low-grade B-cell lymphoma of mucosa associated lymphoid tissue (MALT) was established, re-evaluation of gastric lymphoma was carried on and optimal treatment protocol of MALT lymphoma has been anticipated. Consecutive 40 surgical cases of gastric B-cell lymphoma were histopathologically reclassified as MALT lymphoma (n=26 ; 18 low-grade and 8 high-grade) and non-MALT lymphoma (n=14), analyzed clinicopathologically including prognosis, and comparatively investigated between two groups. Compared to non-MALT lymphomas, patients of MALT lymphoma often presented no symptoms or vague symptoms with longer history and better prognosis after surgery irrespective of high-grade transformation, lymph node involvement or postoperative chemotherapy. MALT lymphomas exhibited larger extent, superficial spread of the mucosa and submucosa, and evasive margins of the tumor until scrutinized histology. 5-yr survival rate of patients with MALT lymphoma was 94%, significantly higher than 59% of non-MALT lymphoma. However, no significant difference was obtained between 64% of high-grade MALT lymphoma and 59% of non-MALT lymphoma. Gastric MALT lymphomas should be biologically different from conventional non-MALT lymphomas, leading to the optimal surgical treatment of total gastrectomy with level 2 lymph node dissection so far. Newly investigated pathogenesis of MALT lymphoma by Helicobacter Pylori infection would consequently take the clinical transitions of treatment protocol in the future.
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