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1996 Fiscal Year Final Research Report Summary

GENETIC POLYMORPHISM ANLYSIS OF THE CANCER RELATED GENES AND CANCER SUCEPTIBILITY

Research Project

Project/Area Number 07671432
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionNIPPON MEDICAL SCHOOL

Principal Investigator

KATO Shunji  NIPPON MEDICAL SHCOOL FIRST DEPT.OF SURGERY ASSISTANT PROFESSOR, 医学部, 助手 (60224507)

Project Period (FY) 1995 – 1996
KeywordsGENETIC POLYMORPHISM / CYTOCHROME P450 2E1 / CYTOCHROME P450 1A1 / L-myc PROTOONCOGENE / CANCER SUSCEPTIBILITY / DNA ADDUCT
Research Abstract

Research results are summarized as following :
a. For case-controls study subjects, DNA was collected from over 500 gastric cancer, 70 esophageal cancer, 80 liver cirrhosis and hepatocellular carcinoma, 70 breast cancer cases, and over 700 healthy controls.
b. Genetic polymorphism analysis was performed to find the relationship between cytochrome p450 2E1,1A1, glutathione-S-transferase M1 specific genotypes and gastric cancer of hepatocellular carcinoma.
c. Limited associations between CYP2E1 Rsa1 RFLP and hepatocellular carcinoma, between CYPlA1 Exon7 RFLP and gastric cancer were observed in this study (Pharmacogenetics, Cancer, Therapeutic Research, Biomedicine & Pharmacogenetics).

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Shunji Kato,et al: "Cytochrome P4502E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease" Pharmacogenetics. 5. 141-144 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kato S.et al: "Genetic and Environmental Risk Factors for the Gastric Cancer" 1st Internal Gastric Cancer Congress (ed Nishi et al). 385-389 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shunji Kato,et al: "Human Lung Carcinogen-DNA Adduct Levels Mediated By Genetic" J Nat Cancer Inst. 87. 902-907 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加藤俊二、他: "Helicobacter pylori感染と胃粘膜萎縮および胃発癌に関する遺伝子の多型性分析:分子疫学的手法による解析" 消化器癌の発生と進展. 7. 129-132 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shunji Kato et al: "Genetic Polymorphisms of the Cancer Related Gene and Helicobacter pylori Infection in Japanese Gastric Cancer Patients : An Age and Gender Matched Case-Control Study" Cancer. 77. 1654-1661 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加藤俊二、他: "萎縮性胃炎、腸上皮化生、胃癌SEQUENCEにおけるHelicobacter pylori感染と遺伝子多型性分析" Theapeutic Research. 17. 4232-4238 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加藤俊二、山下精彦: "宿主因子(遺伝的素因)と病気:遺伝子の多様性による宿主側の因子からみた癌や疾病の発生" 東京都医師会雑誌. 49. 67-69 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加藤俊二、他: "「Mitomycin C-DNA複合体の体内分布(臓器分布)と経時的変化:ヒトおよびラット正常組織におけるMitomycin Cの影響」" 癌と化学療法. 23. 1031-1037 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kato S.,et al: "Genetic polymorphisms of cancer related-genes for gastric and esophageal carcinogenesis" Recent Advances in Gastro-enterological Carcinogenesis I (ed. E. Tahara). 317-320 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kato S.,et al: "Helicobacter pylori infection and genetic polymorphisms for cancer-related genes in gastric carcinogenesis" Biomedicine & Pharmaco-therapy. (In press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shunji Kato, et al: "Cytochrome P4502E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease" Pharmacogenetics. 5. 141-144 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kato S,et al: "Genetic and Environmental Risk Factors for the Gastric Cancer" 1st Internal Gastric Cancer Congress (ed.Nishi et al). 385-389 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shunji Kato, et al: "Human Lung Carcinogen-DNA Adduct Levels Mediated By Genetic Polymorphisms In Vivo" J Nat Cancer Inst. 87. 902-907 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shunji Kato, et al: "Genetic Polymorphisms of the Cancer Related Gene and Helicobacter pylori Infection in Japanese Gastric Cancer Patients" An Age and Gender Matched Case-Control Study Cancer. 77. 1654-1661 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kato S., et al: "Genetic polymorphisms of cancer related-genes for gastric and esophageal carcinogenesis" Recent Advances in Gastroenterological Carcinogenesis I (ed.E.Tahara). 317-320 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kato S., et al: "Helicobacter pylori infection and genetic polymorphisms for cancer-related genes in gastric carcinogenesis" Biomedicine & Pharmacotherapy. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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