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1997 Fiscal Year Final Research Report Summary

Hypothermia for the Management of Low Cardiac Output State after Open Heart Surgery

Research Project

Project/Area Number 07671482
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKagoshima University

Principal Investigator

MORIYAMA Yukinori  Kagoshima University, University Hospital. Assistant Professor, 医学部・附属病院, 講師 (80221638)

Co-Investigator(Kenkyū-buntansha) IGURO Yoshihumi  Kagoshima University, University Hosptial. Research Associate, 医学部・附属病院, 助手 (20222854)
MASUDA Hiroshi  Kagoshima University, University Hospital. Research Associate, 医学部・附属病院, 助手 (10253866)
Project Period (FY) 1995 – 1997
KeywordsHypothermia / Postcardiotomy ventricular failure / IABP / Oxygen consumption
Research Abstract

Surface-cooling hypothermia was applied in 9 patients together with intraaortic balloon pump (IABP) support for postcardiotomy ventricular failure. They consisted of 3 coronary artery bypass graftings (CABGs), 2 aortic valve replacement (AVRs), 1 repair for left ventricular rupture after mitral valve replacement (MVR), 1 MVR+CABG,1 MVR+AVR+tricuspid valve annuloplasty, and 1 Hemiarch repair. The criteria for induction of hypothermia was less than 2.0 L/min/m^2 of cardiac index with greater than 18mmHg of pulmonary capillary wedge pressure under IABP and maximum pharmacologic support. Blood temperature was maintained at around 33゚C to keep mixed venous oxygen saturation up to 50%. After induction of hypothermia, the tissue oxygen consumption decreased significantly with no hemodynamic deterioration. All nine patients finally discontinued IABP support and six of them were ultimately discharged from the hospital. We believe that the use of hypothermia with IABP support become one of the therapeutic options in selected cases of postoperative cardiac failure.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Yukinori Moriyama: "Successful Application of Hypothermia Combined with Intra-AorticBalloon Pump Support to Low-Cardiac-Output State Open Heart Surgery" Angiology. 47・6. 595-599 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 四元 剛一: "術後重症心不全の低体温管理" 日本低体温研究会会誌. 17・1. 48-55 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 四元 剛一: "心保存における心筋浮腫と心臓リンパの実験的検討-ヒアルロニダーゼの効果について-" 日本外科学会雑誌. 98・3. 404-404 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 井畔 能文: "最新の胸部外科1997" 日本胸部外科学会卒後教育委員会, 366 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yukinori Moriyama, Yoshihumi iguro, Shinji Shimokawa, Hideaki Saigenji, Hitoshi Toyohira, Akira Taira: "Successful Application of Hypothermia Combined with Intra-Aortic Balloon Pump Support to Low-Cardiac-Output State After Open Heart Surgery" Angiology. 47(6). 595-599 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Goichi Yotsumoto, Yukinori Moriyama, Yoshifumi Iguro, Tamahiro Kinjo, Akihiro Yamaoka, Shinji Shimokawa, Hitoshi Toyohira, Akira Taira: "Hypothermia for the management of low cardiac output state after open heart surgery" The Journal of the Japanese Society for Hypothermia. 17(1). 48-55 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Goichi Yotsumoto, Yukinori Moriyama, Akihiro Yamaoka, Koichi Hisatomi, Tamahiro Kinjyo, Hiroshi Masuda, Akira Taira: "Efficacy of hyaluronidase on myocardial edema and cardiac lymph in graft preservation -An experimental study-" The Journal of Japan Surgical Society. 98(3). 404- (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshihumi Iguro: "Hypothermic Management for Low Output Syndrome" Saisinnokyobugeka 1997 The Japanese Association for Thoracic Surgery Tokyo. 225-228

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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