1997 Fiscal Year Final Research Report Summary
Morphological and immunohistochemical changes of the facial nucleus in the rat hemifacial spasm model
| Project/Area Number |
07671496
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yamagata University |
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Principal Investigator |
SAITO Shinjiro Yamagata University, Department of Neurosurgery, Assistant Professor, 医学部, 講師 (60153805)
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| Co-Investigator(Kenkyū-buntansha) |
KUROKI Akira Yamagata University, Department of Neurosurgery, Assistant Professor, 医学部, 講師 (90225285)
KAYAMA Takamasa Yamagata University, Department of Neurosurgery, Professor, 医学部, 教授 (50142972)
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| Project Period (FY) |
1995 – 1997
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| Keywords | hemifacial spasm / facial nerve / abnormal muscle response / vascular compression / demyelination |
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| Research Abstract |
We had previously reported that the abnormal muscle response, which is thought to be a specific response only seen in patients with hemifacial spasm, can be recorded in the model rat.
In this study we recorded evoked potentials from the facial motonucleus of rats in response to electrical stimulation of the temporal branch of the facial nerve in which chronic irritation from a blood vessel had caused the development of an abnormal muscle response. In the recordings from the motonucleus in model rats there was a late component at a latency of about 5 msec, in addition to the early component with a latency of 1.5-2.5 msec that is also observed in normal rats. The latency study showed that the late component of the recordings from the motonuclues was stronglycorrelated the abnormal muscle response obtained from the mentalis muscle in response to electrical stimulation of the temporal branch of the facial nerve. We also found demyelination more frequently at the site of chomic gut suture placed than at the normal part of the facial nerve. The results of this study further support the hypothesis that the hyperactivity of the facial motonucleus is the pathophysiology of hemifacial spasm.
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