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1996 Fiscal Year Final Research Report Summary

Phathophysiology of spinal cord blood circulation, biochemical study.

Research Project

Project/Area Number 07671517
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKobe University

Principal Investigator

EHARA Kazumasa  School of Med.Neurosurgery, Kobe University, Assoc.Prof, 医学部, 助教授 (20151996)

Co-Investigator(Kenkyū-buntansha) NAGASHIMA Tatsuya  Univ.Hosp.Neurosurgery, Assist.Prof, 医学部附属病院, 講師 (80201680)
TAMAKI Norihiko  School of Med.Neurosurgery, Kobe University, Prof, 医学部, 教授 (10030941)
Project Period (FY) 1995 – 1996
Keywordsspinal cord / ischemia / syringomyelia
Research Abstract

There are many controversial issues on the pathogenesis of the syringomyelia. The ultrastructural changes occurring in the spinal cord in a hydrosyringomyelic rabbit model were investigated by light microscopy and transmission electron microscopy.
Hydrosyringomyelia was induced into 18 adult rabbits by intracisternal injection of 25% kaolin. All of the rabbits were killed two, four, and six weeks and six months after the kaolin injection by transcardial perfusion of glutaraldehyde-paraformaldehyde solution in cacodylate buffer. About 1 mm thick sections were taken from various levels of spinal cord segments, and processed for the light and transmission electron microscopy.
In all animals, the syrinx extended posteriorly between the dorsal white columns. white matter adjacent to the syrinx was edematous. Extreme perivascular space enlargement had occurred both in the gray and white matter. Myelin sheaths were split up, thinned out and completely lost in some nerve fibers near the syrinx, while the axon itself was lost in many other fibers. Remyelination by oligodendrocytic processes was seen in some denuded axons. Astrocytic processes containing huge bundles of glial filaments covered many fibers which were exposed to the syrinx. No extravasation of Evans blue was seen on concal microscopy. Axonal degeneration, demyelination, and final complete loss, and simultaneous astrocytic proliferation and remyelination by oligodendrocytes were observed. These ultrastructural changes have many similarities to those seen in hydrocephalus and autopsy findings of human syringomyelia.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Chakrabortty, S他: "Experimental syringomyeliu : Late ultrastructural changes of spinal cord kissue and magnetic resonance imaging evaluation" Surg Neurol. (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 長嶋 達也 他: "脊髄結核腫に伴なった脊髄空洞症の1治験例" 日本パラプレジア 医学雑法. 8-1. 146-147 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玉木 紀彦: "脊髄の先天異常 -その成因と病態-" Orthopaedics. 8-4. 1-8 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玉木 紀彦: "二分脊椎に伴なう脊髄空洞症" 日本パラプレジア医学雑法. 8-1. 148-149 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 長嶋 達也(著): "玉木紀彦(編)臨床神経学 -神経放射線学的診断治療の進歩" メディカ出版, 265 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chakrabortty S,et al.: "Experimental sylingomyelia : Late ultrastructural changes of spinal cord tissue and magnetic resonance image evaluation." Surg Neurol. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagashima T,et al.: "Sylingomyelia associated with spinal cord tuberculoma, a curative case" Jpn J of Palaplegia Society. 8-1. 146-147 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamaki N,et al.: "Congenital malformation of spinal cord. Etiology and pathophysiology." Orthopaedics. 8-4. 1-8 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamaki N: "Syringomyelia associated with spina-bifida." Jpn J of Palaplegia Society. 8-1. 148-149 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamaki N.(ed.): Clinical Neurology, recent progress of neuroradiological diagnosis and treatment. Medica Publishing Co.Ltd., 265 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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