1996 Fiscal Year Final Research Report Summary
STUDY OF THE CHANGE OF CEREBRAL SUPEROXIDE SCAVENGING ACTIVITY IN FORMING EDEMA
| Project/Area Number |
07671520
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | OKAYAMA UNIVERSITY |
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Principal Investigator |
KAWAUCHI Masamitsu OKAYAMA UNIVERSITY MEDICAL SCHOOL ASSISTANT, 医学部, 助手 (20252950)
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| Co-Investigator(Kenkyū-buntansha) |
TOMITA Susumu OKAYAMA UNIVERSITY MEDICAL SCHOOL ASSISTANT, 医学部, 助手 (90237115)
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| Project Period (FY) |
1995 – 1996
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| Keywords | head injury / oxigen radical / SOD / ESR |
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| Research Abstract |
Oxygen-derived free radicals have been reported to be involved in the secondary self-destructive mechanisms occuring after TBI.
In the present study, we investigated the intensity of brain hydroxyl radical (OH) generation, using electoron spin trapping method (ESR), and lipidperoxidation to examine the relationship between free radicals and lipid peroxidative tissue damage. And we analyzed endogenous Cu, Zn-SODmRNA expression and SOD activity to examine the effect of lecithinized SOD (PC-SOD) on TBI.
Our results show that the degree of posttraumatic brain edema as closely correlated with the increase of the generation of OH radical and lipid peroxidation tissue damage. PC-SOD increased SOD activity and decreased brain edema.
These findings demonstrate that superoxide may play an important role in development of edema after TBI,and suggest the potential the rapeutic selectiviey of the PC-SOD therapy strategy.
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