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1997 Fiscal Year Final Research Report Summary

Hemodynamic Depression and Microthrombosis Formation in the Peripheral Areas of Cerebral Contusion

Research Project

Project/Area Number 07671547
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNihon University

Principal Investigator

YAMAMOTO Takamitsu  Nihon Univ.Dep.of Neurological Surgery Assistant Professor, 医学部, 講師 (50158284)

Co-Investigator(Kenkyū-buntansha) TSUBOKAWA Takashi  Nihon Univ.Science Research Center Professor, 総合科学研究所, 教授 (80058958)
KATAYAMA Yoichi  Nihon Univ.Dep.of Neurological Surgery Professor, 医学部, 教授 (00125048)
Project Period (FY) 1995 – 1997
Keywordstrauma / brain injury / cerebral contusion / cerebral blood flow / microthrombosis / brain edema / tissue osmolality / rat
Research Abstract

Cerebral contusious sometimes cause progressive or delayd deterioration of neurological symptoms, which may result from secondary injury processes of the traumatized brain. It is important to elucidate pathophysiology underlying secondary brain damages, since one principal goal of treatments for traumatic brain injury is to prevent such secondary damages following the injury. In the present syudy, in order to elucidate the mechanisms of contusion-induced secondary cell injury processes, we investigated hemodynamic changes in cerebral contusion, and effects of anti-thrombosis and anti-coagulate drugs were tested in a rat cortical contusion induced by a controlled cortical impact device. Results (1)Histological examinations revealed that the initial histopathological finding in the peripheral area of contusion was microthrombosis formation, followed by brain edema and necrosis formation. These changes progressively extended to peripheral area surrounding the contusion. (2)In the central … More area of contusion, cerebral blood flow (CBF) was decreased to the ischemic level within 5-15 min after the injury induction. In the peripheral area, CBF was decreased to 20% of the beseline, returned to 40-60% level, and then decreased again to the ischemic level without any recovery. (3)A inhibitor of platelet activating factor (PAF), etizolam, attenuated the contusional necrosis formation as well as decreasing CBF in the peripheral but not in the central area of contusion. (4)The tissue osmolality of contusion increased immediately following the injury, and the tissue water content increased thereafter. (5)The concentration of the tissue cations (total amount of [Na^+]+[K^+] in the contusion did not show any significant changes, indicating inorganic ions do not mainly participate in the tissue osmolality increase. Discussion The results of the present study indicate that the microthrombosis formation in the peripheral areas of contusion may contribute to the secondary cell injury processes in cerebral contusion. Anti-thrombosis with a PAF antagonist has a therapeutic potential to attenuate the lschemic btain damage and subsequent edema formation following the contusion. The progressive increase in tissue osmolality is another cause of contusion-induced edema formation. Increases in metabolic intermediate osmoles and/or idiogenic osmoles resulting from the catabolic degradation of intracellular high molecular substances, e.g.phospholipids in cell membrane, may play a major role for the formation of osmotic potential and a resultant brain edema in the cerebral contusion. Less

  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 山本 隆充、片山 容一、他: "骨傷のない頚椎損傷急性期の治療法:Killed end corticospinal evoked potentialの推移からみた治療法の検討" 日本パラプレジア医学会雑誌. 9(1). 24-25 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山本 隆充、片山 容一、他: "大脳皮質運動領の直接刺激法と経頭蓋電気刺激法によって記録されるMEPの比較:同一症例における術中モニタリングの結果から" 脊髄電気診断学. 18(1). 143-146 (1996)

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      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto T, Katayama Y, etc: "A study of methods of evaluating prolonged consciousness disturbance : Based on the results of deep brain stimulation therapy and long-term follow-up" The Society For Treatment of Coma. Vol.5. 99-102 (1996)

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      「研究成果報告書概要(和文)」より
  • [Publications] Aoyama N, Katayama, Y et al.: "Microthrombosis formation in cerebral contusion : A cause of trauma-induced secondary tissue damage" Advances in Neurotrauma Rescarch. Vol.7. 85-90 (1996)

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  • [Publications] Mori T, Katayama Y, Yamamoto T, et al.: "Progressive edema fomation in contused brain : Role of tissue osmolality and ion concentrations" Advances in Neurotrauma Research. vol.8. 15-17 (1997)

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      「研究成果報告書概要(和文)」より
  • [Publications] 山本 隆充、片山 容一: "遷延性意識障害の治療" 救急医学. 21. 1737-1742 (1997)

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      「研究成果報告書概要(和文)」より
  • [Publications] 山本 隆充: "最新脳神経外科学 手術中のモニター法" 1880(1137-1144) (1996)

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  • [Publications] Yamamoto T,Hirayama T,Katayama, Tsubokawa T,et al.: "Significance of neurological evaluation of the vegetative state" The society for treatment of coma. 4. 247-251 (1995)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto T,Fukaya C,Katayama Y,et al.: "A study of methods of evaluating prolonged consciousness disturbance : Based on the results of deep brain stimulation therapy and long-term follow-up" The Society For Treatment of Coma. 5. 99-102 (1996)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto T,Katayama Y,Maejima S,et al.: "5-HT3 antagonist for the treatment of central pain : comparison with the results of pharmacological tests" Pain Research. 12. 109-114 (1997)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto T,Katayama Y,Tsubokawa T,et al.: "Pharmacological classification of central post-stroke pain : comparison with the results of chronic motor cortex stimulation therapy" Pain. 72. 5-12 (1997)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Aoyama N,Katayama Y,Tsubokawa T,et al.: "Microthrombosis formation in cerebral contusion : A cause of trauma-induced secondary tissue damage." Advances in Neurotrauma Research. 7. 85-90 (1995)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Katayama Y,Koshinaga M,Tsubokawa T,et al.: "Role of excitatory amino acid-mediated ionic fluxes in traumatic brain injury." Brain Pathology. 5. 427-435 (1995)

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  • [Publications] Koshinaga M,Suma K,Maeda T,Katayama Y: "The role of traumatic depolarization and cytokine release in glial responses following traumatic brain injury." Neurotraumatology. 19. 167-172 (1996)

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  • [Publications] Kurihara J,Yamamoto T,Katayama Y,et al.: "Experimental spinal cord injury induced by a controlled impact device : Electrophysiological and histological investigations" Advances in Neurotrauma Research. 8. 61-64 (1996)

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  • [Publications] Maeda T,Aoyama N,Katayama Y,et al.: "Selective neuronal cell death in the hippocampus following cortical contusion : role of EAA and programd cell death." Brain Hypoxia. 10. 79-81 (1996)

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  • [Publications] Maeda T,Kawamata T,Katayama Y: "Effect of hypothermia on hippocampal cell damages in the rat cortical impact contusion model." Neurotraumatology. 19. 162-166 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mori T,Katayama Y,Yamamoto T,et al.: "Progressive edema formation in contused brain : Role of tissue osmolality and ion concentrations" Advances in Neurotrauma Research. 8. 15-18 (1996)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Suma T,Maeda T,Kano T,Katayama Y,et al.: "Temporal pattern of microglial response in adult rat hippocampus following direct infusion of granulocyte-macrophage colony stimulating factor." Advances in Neurotrauma Research. 7. 112-116 (1995)

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  • [Publications] Kawamata T,Maeda T,Kano T,Katayama Y et al.: "Relative ischemic condition in traumatic brain injury." Neurotraumatology. 19. 128-132 (1996)

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  • [Publications] Katayama Y,Maeda T: Head Injury, Basic Research. In : Neurosurgical Review Vol.3('95). Miwashyoten, Tokyo, 153-165 (1995)

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      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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