1996 Fiscal Year Final Research Report Summary
EFFECTS OF SYMPATHETIC ACTIVITY ON THE MICROCIRCULATION IN THE FACIAL NERVE
| Project/Area Number |
07671695
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | HYOGO COLLEGE OF MEDICINE |
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Principal Investigator |
MURAKAWA Kazushige Hyogo College of Medicine, Department of Anesthesiology, Associate Professor, 医学部, 助教授 (70104263)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Shigeo Hyogo College of Medicine, Department of Anesthesiology, Assistant, 医学部, 助手 (50268554)
MATSUDA Masaya Hyogo College of Medicine, Department of Anesthesiology, Assistant, 医学部, 助手 (20258156)
NOMA Kenichi Hyogo College of Medicine, Department of Anesthesiology, Assistant, 医学部, 助手 (00218348)
MINATOGAWA Tohru Hyogo College of Medicine, Department of Otolaryngology, Associate Professor, 医学部, 助教授 (00068488)
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| Project Period (FY) |
1995 – 1996
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| Keywords | FACIAL NERVE / BELL'S PALSY / SYMPATHETIC NERVE / MICRO-CIRCULATION / TISSUE BLOOD FLOW |
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| Research Abstract |
Micro-circulatory disorders of the facial nerves in the tepmporal bone plays an important role in the pathogenesis of Bell's palsy. Although the mechanism of the cause of circulatory impairment is still unknown, the activities of the sympathetic nervous system in the head and neck are said to be an essential factor in the changes of the micro-circulatory system. To examine this relationship, the changes in the sympathetic nervous system activities during electrical stimulation, chemical blockage, and hypo- or hypercapnia as well as associated changes of blood flow in the common carotid artery and the facial nerve tissue, were examined using dogs. Animal were anesthetized intravenusly and intubated with artificial ventilation. As cervical sympathetic activity, electrical stimulation of the cervicothoracic ganglions and as the chemical blockage, local anesthetics was applied locally. Hypo- or hypercapnia induced by hyper- or hypoventilation. The blood flow changes in the common carotid artery were measured with an electromagnetic flowmeter and those in the facial nerve tissue with a laser Doppler tissue blood flowmeter. Blood flow was markedly decreased in both areas with electrical stimulation. To the contrary, when mepivacaine was applied to the ganglions, blood flow was markedly increased in both areas. With the hypercapnia, the blood flow in the common carotid artery increased, however the tissue blood flow of the facial nerve decreased. The hypocapnia decreased the common carotid arterial blood flow but did not change in the facial nerve tissue blood flow. These findings suggested that the micro-circulation of the facial nerve is definitely impaired with an elevated activity of the cervical sympathetic system, and the denervation of this system improves the blood flow. Based on these results, it was assumed that sympathetic activity is closely related to the micro-circulation of the facial nerve.
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