Electrically Induced Auditory Brainstem Response as a Clinical Tool in Explicating Sudden Deafness

1996 Fiscal Year Final Research Report Summary

• Project/Area Number: 07671869
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Miyazaki Medical College
• Principal Investigator: USHISAKO Yasuaki Miyazaki Medical College, Medical Science, Assistant, 医学部, 助手 (10185001)
• Co-Investigator(Kenkyū-buntansha): TONO Tetsuya Miyazaki Medical College, Medical Science, Assistant Professor, 医学部, 助教授 (80145424)
• Project Period (FY): 1995 – 1996
• Keywords: EABR / sudden deafness / Feosemide / stria vascularis

Research Abstract

(1)Auditory brainstem responses to electrical stimulation (EABR) could be easily obtained by using bipolar electrodes in cochlear of guinea pig.
(2)EABR to 500muA electrical stimulation in normal guinea pig showed five different positive peaks, but EABR wave forms were much different in each other than ABR wave forms.
(3)Each peak latencies of EABR to 500muA were shortened about 1msec. compairing from its of ABR.
(4)The mean EABR threshhold in normal guinea pigs was 55muA,ranging from 20muA to 100muA.
(5)Cochlear damages caused by inserting electrodes for EABR recording introduced 8dB ascending in ABR threshhold.
(6)Any latencies and thresholds in our EABR recordings were not infruenced by administrating 100mg/kg Frosemide.
(7)Any latencies and thresholds in our EABR recordings were not infruenced by administrating 40mg/kg Kanamicine for 14 days.