1996 Fiscal Year Final Research Report Summary

Immunohistochemical and molecular biological study on abnormality of adenomatous polyposis coli gene in oral cancer and premalignant lesion.

Research Project

Project/Area Number	07671962
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Morphological basic dentistry
Research Institution	CHIBA UNIVERSITY
Principal Investigator	TANZAWA Hideki CHIBA UNIVERSITY,SCHOOL OF MEDICINE,ASSOCIATE PROFESSOR., 医学部, 助教授 (50236775)
Co-Investigator(Kenkyū-buntansha)	SATO Kenichi CHIBA UNIVERSITY,SCHOOL OF MEDICINE,PROFESSOR., 医学部, 教授 (40009139) ATSUTA Fujio CHIBA UNIVERSITY,SCHOOL OF MEDICINE,ASSISTANT., 医学部, 助手 (60202644)
Project Period (FY)	1995 – 1996
Keywords	Oral cancer / premalignant lesion / leukoplakia / squamous-cell carcinoma / APC遺伝子
Research Abstract	Abnormalities of adenomatous polyposis coli (APC) gene have been detected in the gastric, esophageal and pancreatic carcinoma, and has been considered as a cause of the development of many malignant tumors derived from various glands. However, we reported that many abnormalities of APC gene were frequently detected in oral squamous-cell carcinoma and that APC gene must be one of the most significant genes for the oncogenesis of oral cancer. In this research, we revealed that abnormalities of APC gene are common events in the process of oncogenesis of oral cancer and that the incidence of them doesn't dependent on the primary site of tumor but on the differentiation level. According to our results, Clinical screening must be tried in near future.