1996 Fiscal Year Final Research Report Summary
The study of mouse salivary gland morphogeensis.
| Project/Area Number |
07671978
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
BERNARD Tandler Kyushu Dental College, Dept.Oral Anat.II,Assistant Professor, 歯学部, 助手 (90271212)
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Hidemitsu Kyushu Dental College, Dept.Oral Anat.II,Assistant Professor, 歯学部, 助手 (70271210)
TOYOSHIMA Kuniaki Kyushu Dental College, Dept.Orals Anat.II Professor, 歯学部, 教授 (10112559)
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| Project Period (FY) |
1995 – 1996
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| Keywords | submandibular gland / morphogenesis / NGF-R / bsl-2 / epithelial-mesenchymal interactions |
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| Research Abstract |
In fetal rat submandibular rudiment, many growth factors (EGF,TGF-a, NGF,HGF) and their receptors were detected by immunohistochemical staining. These results suggested that growth factor systems were important for epithelial morphogenesis and branching of the epithelium into the mesenchyme.
In adult rat submandibular gland, bcl-2 staining was confined to striated duct cell. On the other hand, bcl-2 was positive at all of fetal submandibular rudiment cell. It was suggested that bcl-2 expression in fetal submandibular rudiment relate to epithelial-mesenchymal interactions, play an important role in differentiation and prolifteration of submandibular rudiment.
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