1996 Fiscal Year Final Research Report Summary
Detection of malignancies of head and neck cancer using PET and change induced by radiation therapy
| Project/Area Number |
07672056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | Iwate medical university |
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Principal Investigator |
SHOZUSHIMA Masanori Iwate Med.Univ.Sch.Dent., Ass.Prof., 歯学部, 助教授 (00118259)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Head and neck / malignant tumor / FDG / PET |
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| Research Abstract |
The positron emission tomography (PET) tracer 2-18F-fluoro-2-deoxy-D-glucose (FDG) is the most widely used tracer in oncology. This study was undertaken to evaluate PET in the detection of head and neck malignancies, compared to analysis of MRI,CT and histopathological findings.
A total of 17 patients with malignant tumors were examined with FDG.PET revealed that each biopsy-proven primary lesion is an area of increased FDG uptake. Metastatic lymph node has been demonstrated in two cases by the pathologic findings. The smallest metastatic lymph node detected in the retropharyngeal space by FDG-PET was 4mm. The uptake of FDG in lymph nodes were studied from 10 to 60 min after a injection of FDG.Metastatic lymph node uptake increased gradually after injection, whereas reactive node uptake decreased. The FDG uptake ratio was seemed depend on the rate between tumor cells and interstitial tissue in malignant lesion. In this series, the authors found that FDG-PET is a useful diagnostic modality for evaluation the patient with head and neck cancers.
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