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1996 Fiscal Year Final Research Report Summary

Effects of antioxidants on the polymerization and lipid peroxidation in dental resin materials

Research Project

Project/Area Number 07672106
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionMeikai University

Principal Investigator

FUJISAWA Seiichiro  School of Dentistry, Meikai University, Prof., 歯学部, 教授 (40014162)

Co-Investigator(Kenkyū-buntansha) KADOMA Yoshinori  Tokyo Medical & Dental Uni.Assoc.Prof., 医用器材研究所, 助教授 (00092403)
Project Period (FY) 1995 – 1996
KeywordsPhotosemsitizer / Camphorquinone / 9-Fluorenon / visible light irradiation / antioxidant / reactive oxgen / ACAS Laser Cytometry / Peroxid indicator
Research Abstract

Benzoyl peroxide, photosensitizer and other redox systems are used as an initiator of the free-radical initiator and propergation of methyl methacrylate polymerization. They cause the damage of cell membranes due to the lipid peroxidation of phospholipids in cell membranes. Antioxidants such as vitamin E,vitamin C,histidine, hydroquinone, etc. They are a scavenger of free radicals. Effets of photosensitizer (camphorquinone CQ,9-fluorenone 9F) in the presense of dimethyl aminoethyl methacrylate (reducing agent) with visible-light irradiation on human submandibular gland adenocarcinoma cell line HSG were investigated by the percentage of cell survival and the production of reactive oxygen measured with ACAS laser cytometer and a peroxide indicator (5- (and 6) -carboxyl-2', 7'-dichloro fluorecin diacetate).
The amount of reactive oxygene generated in the cells irradiated in the 9F system was larger than that of the CQ system.
The decrease in % survival in the 9F system was greater than that in the CQ system. The 9F system gave much stronger damage to the cell than the CQ system due to the production of reactive oxygens.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 藤沢盛一郎: "BPOによるメチルメタクリレート重合におよぼすビタミンEの影響" 歯材器. 15. 483-488 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.ITO: "NMR studies on dental adhesive monomer.Complete Assignment of ^<13> C-NMR spectrum and gemetrical study of 5-methacryloy aminosahcylic acid" Dental Material Journal. 15. 1-10 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S Fujisawa: "Action of eugenol as a retarder against polymerization of methylmethacrylate by benzoly peroxicle" Biomaterials. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤沢盛一郎: "メチルメタクリレート重合に及ぼすα-トコフェロール、β-カロチンの影響" 歯材器 Special lssue. 15. 38-39 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤沢盛一郎: "Eugenol,EBAおよびその関連化合物とCa^<2+>相互作用-NMR研究-" 歯材器 Special lssue. 15. 320-321 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ito: "Complete BC-NMR assigment of dental adhesive monower 4-inethacryicxy ethyltrimelitate and its hydrate by NMR spetniscopy" Magnetic Resonance in chenistry. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ito, S.: "NMRstudies on dental adhesive monomer complete assignment of 13C-NMR spectrum and geometrical study of 5-methacryloyl aminosalicylic acid." Dent Mater J.15. 1-10 (1966)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ito, S.: "Complete 13C-NMR assignment of dental adhesive monomer 4-methacryloyloxyethyl trimellitate anhydride and its hydrate by NMR spectroscopy, Note to Magnetic Resonance in Chemistry" Magnetic Resonance in Chemistry J Son Co. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujisawa S.: "Effects of vitamin E on the polymerization of methyl methacrylate by BPO" JJSDen Mat&Dev. 15,6. 483-488 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujisawa S.: "Action of eugenol as aretarder against polymerization of methacrylate by benzoyl peroxide." Biomaterials. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujisawa S.: "Effects of alpha tocopherol and beta carotene on the polymerization of methyl methacrylate" JJSDen Mat&Dev specia issue. 27. 38-39 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujisawa S.: "NMR study of the interaction of eugenol, EBA and their related compounds with Ca2+" JSDen Mat&Dev Specia issue. 28. 320-21 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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