1996 Fiscal Year Final Research Report Summary

Basic Research on Antitumor Effects of Platinum Analogue combined with Hyperthermia.

Research Project

Project/Area Number	07672175
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	HIROSHIMA UNIVERSITY
Principal Investigator	YOSHIGA Koji Hiroshima University, School of Dentistry, Associate Prof., 歯学部, 助教授 (70112216)
Co-Investigator(Kenkyū-buntansha)	SAKURAI Kazuhiro Hiroshima University, School of Dentistry, Assistant, 歯学部, 助手 (70253094)
Project Period (FY)	1995 – 1996
Keywords	HYPERTHEMIA / PLATINUM / 温熱化学療法
Research Abstract	From 1995 we studied on antitumor effects of platinum analogue combined with hyperthermia. The mechanisum of antitumor effects was showed that increasing of tissue and intracellular concentration of drug. In this year the developmental study was performed about details of mechanisum of antitumor effect. 1.Hyperthemia affected on Pt transport by the way active transport. 2.The increasing of crosslinkage of Pt ion to DNA was seemed one of the mechanisum of antitumor effects platinum combined with hyperthermia.

(4 results)