1996 Fiscal Year Final Research Report Summary
Basic Research on Antitumor Effects of Platinum Analogue combined with Hyperthermia.
| Project/Area Number |
07672175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
YOSHIGA Koji Hiroshima University, School of Dentistry, Associate Prof., 歯学部, 助教授 (70112216)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Kazuhiro Hiroshima University, School of Dentistry, Assistant, 歯学部, 助手 (70253094)
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| Project Period (FY) |
1995 – 1996
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| Keywords | HYPERTHEMIA / PLATINUM / 温熱化学療法 |
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| Research Abstract |
From 1995 we studied on antitumor effects of platinum analogue combined with hyperthermia. The mechanisum of antitumor effects was showed that increasing of tissue and intracellular concentration of drug.
In this year the developmental study was performed about details of mechanisum of antitumor effect.
1.Hyperthemia affected on Pt transport by the way active transport.
2.The increasing of crosslinkage of Pt ion to DNA was seemed one of the mechanisum of antitumor effects platinum combined with hyperthermia.
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