1996 Fiscal Year Final Research Report Summary
Study on apo A-IV polymorphism in patients with hyperlipidemia.
| Project/Area Number |
07672485
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gifu University |
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Principal Investigator |
SEISHIMA Mitsuru Div.Central Lab.Gifu Univ.School.Med.Assis.Prof., 医学部・附属病院, 講師 (10171315)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Kuniaki Dep.Lab.Med.Gifu Univ.Schol.Med.Instructor, 医学部, 助手 (80262765)
NOMA Akio Dep.Lab.Med.Gifu Univ.Schol.Med.Prof., 医学部, 教授 (30208384)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Apo A-IV / Polymorphism / Hyperlipidemia |
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| Research Abstract |
We compared the frequencies of apo A-IV polymorphism at codon 347 and 360 in 40 hyperlipidemic patients with 131 healthy controls. All healthy controls and hyperlipidemic patients studied here had Thr/Thr at codon 347. This result was different with a report in Western, which showed the frequency of Ser allele was 0.144 to 0.216. On the other hand, the frequency of Gln/llis at codon 360 in hyperlipidemic patients was 17.5%, which was lower than 22% in controls although there was no statistical difference between them. It is well known that Gln/Gln and His/His at codon 360 are corresponded to A-IV-1 and A-IV-2, respectively at protein level. It has been reported that subjects with A-IV-2 show higher HDL-C and LCAT activity compared to those with A-IV-1.
In addition, A-IV-2 regulates cholesterol absorbtion in the small intestine. These isoforms, thus, have different functions in the lipid metabolism. In view of this point, few frequency of Gln/His (A-IV-2) in hyperlipidemic patients may indicate that this varient is associated with the cause for hyperlipidemia. However, in the present study, we could not find the difference in the frequency of apo A-IV polymorphism among subtypes of hyperlipidemia, but further study will be necessary in large scale of number.
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Research Products
(8 results)
