1996 Fiscal Year Final Research Report Summary
Phospholipid translocase : Its role in cytoskeletal reorganization.
| Project/Area Number |
07680788
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | The Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
UMEDA Masato THE TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE,DEPARTMENT OF INFLAMMATION RESEARCH, 炎症研究部門, 研究員 (10185069)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Kenichi THE TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE,DEPARTMENT OF INFLAMMATION R, 炎症研究部門, 研究員 (70270684)
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| Project Period (FY) |
1996
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| Keywords | phospholipid asymmetry / phospholipid translocase / flip-flop / anti-idiotypic antibody / cell division / cytokinesis / actin / cytoskeleton |
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| Research Abstract |
Recent advances in molecular genetics have provided powerful tools for studying the biological function of proteins, resulting in rapid extension of our knowledge of their functions. However, little is still known about the organization and function of biological membranes, especially how membrane phospholipids are organized and participate in cellular functions. This is mainly because of the lack of appropriate methodologies for either manipulating or tracing the function of membrane lipids. We have developed various probes to analyze the moleculaer motion and function of phospholipids in biological membranes. Our studies have shown that enhanced transbilayr movement of plasma membrane phospholipids plays a pivotal role in mediating coordinated movement between cytoskeletal proteins and plasma membrance to achieve successful cell dividion.
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[Publications] Igarashi, K., Kaneda, M., Yamaji, A., Saido, T.C., Kikkawa, U., Ono Y., Inoue, K., Umeda, M.: "A novel phosphatidylserine-binding peptide motif defined by an anti-idiotypic monoclonal antibody : Localization of phosphatidylserine-specific binding sites on protein kinase C and phosphatidylserine decarboxylase." J.Biol. Chem.270. 29075-29078 (1995)
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[Publications] Tokita, S., Arai, M., Yamamoto, N., Katagiri, Y., Tanoue, K., Igarashi, K., Umeda, M., Inoue, K.: "Specific cross-reaction of IgG anti-phospholiopid antibody with platelet glycoprotein IIIa." Thrombosis. Haemostasis.75. 168-174 (1996)
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