• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1997 Fiscal Year Final Research Report Summary

Long-term Potentiation and Neural Coding of Learning, Memory in Rat Hippocampus

Research Project

Project/Area Number 07680867
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

FUKUDA Masaji  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY,Fac.Medicine, Behav.Sci., Professer, 医学部, 教授 (60126547)

Co-Investigator(Kenkyū-buntansha) ONO Taketoshi  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY,Fac.Med.Physiology, Professer, 医学部, 教授 (50019577)
Project Period (FY) 1995 – 1997
Keywordshippocampus / learning / memory / physiology / rat
Research Abstract

(1) Interaction between place cell activity in rat hippocampal CA1 and low (1Hz) or high (100Hz) frequency electrical stimulation of the Scaffer collaterals was studied. High frequency stimelation impaired both random wandering and spatial navigation tasks, motivated by intracranial self-stimulation as a reward. However, low frequency stimulation did not impair its behaviors. The place cell activity was suppressed by high frequency stimulation and, as a result, the place field disappeared just after the stimulation. Within an hour, the nueronal activity and performance of task were recovered to the control level. However, the place fields recovered were different from the control. Low frequency stimulation on the same electrode also modified place field. These suggest that the place dependency in the CA1 neuron may be implemented through the Schaffer collateral of CA3, and that high or frequency information related to the LTP or LTD might be correlated to the place processing.
(2) Lamella hypothesis in rat hippocampus was tested by correlation analysis of two neuronal activities. The two neuronal activities of rat hippocampal CA1 area were simultaneously recorded in an awake and anesthezed state. The normalized cross-correlation values in awake state were smaller than ones of anesthesia state. The complex-spike activity of CA1 pyramidal layr was correlated along septo-temporal axis over 1.1mm apart and showed almost uniform cross-correlation values of 0.02-0.1 in both awake and anesthesia state. These suggest that the neuron in hippocampal CA1 area may connect each other with weak distributed manners.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Nishijo, H., Tabuchi, E., Ono, T., Fukuda, M., Kuze, S.and Endo, S.: "Physiological results of Monkey brain isthenia and protection by a calcium entry blocker" Brain Res,Bull.37. 89-101 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukudo, M., Tamura, R., Kobayashi, T., Nishijo, H.and Ono T.: "Relationship between change of movement direction and actirity of hippocampal place cells" NeuroReport. 8. 3207-3211 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobayashi, T., Nishijo, H., Fukuda, M.Bures, T.and Ono, T.: "Task-dependent representations in rat hippocampal place neurons" J.Neuropheysiol.78. 597-613 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masuda, R., Fukuda, M., Ono, T.and Endo, S.: "Neuronal responses at the sight of objects in monkey basal forebrain subregions during operant uisual tasks" Neurobiol.Learn.Memory. 67. 181-196 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawanishi, C., Fukuda, M., Tamura, R., Nishijo, H.and Ono.T,: "Effects of repeated cold stress of feading,avoidance behavior and pain related fiber activity" Plysiol,Behav.62. 849-856 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 福田 正治、小野 武年 小林 恒之: "海馬体ニューロンと場所学習・記憶" 日本生理学雑誌. 57. 145-154 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishijo, H., Tabuchi, E., Ono, T., Fukuda, M., Kuze, S.and Endo, S.: "Physiological results of monkey brain ischemia, and protection by a calsium entry blocker." Brain Res.Bull.37. 89-101 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuda, M., Tamura, R., Kobayashi, T., Nishijo, H., and Ono, T.: "Relationship between change of movement direction and activity of hippocampal place cells." Neuro Report. 8. 3207-3211 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi, T., Nishijo, H., Fukuda, M., Bures, J.and Ono, T.: "Task-dependent representations in rat hippocampal place neurons." J.Neurophysiol.78. 597-613 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masuda, R., Fukuda, M., Ono, T.and Endo, S.: "Neuronal responses at the sight of objects in monkey basal forebrain subregions during operant visual tasks." Neurobiol.Learn.Memory. 67. 181-196 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawanishi, C., Fukuda, M., Tamura, R., Nishijo, H.and Ono, T.: "Effects of repeated cold stress on feeding, avoidance behavior and pain related fiber activity." Physiol.Behav.62. 849-856 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi