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1997 Fiscal Year Final Research Report Summary

Studies on central nervous mechanisms concerning cognitive functions

Research Project

Project/Area Number 07680902
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 神経・脳内生理学
Research InstitutionKansai Medical University

Principal Investigator

GEMBA Hisae  Kansai Medical University Faculty of Medicine Professor, 医学部, 教授 (00108987)

Co-Investigator(Kenkyū-buntansha) KYUHOU Sin-ichi  Kansai Medical University Faculty of Medicine Assistant Professor, 医学部, 講師 (60195394)
Project Period (FY) 1995 – 1997
KeywordsPrefrontal cortex / Motivation-dependent activity / Monkey / Cerebellectomy / Cortical field potential / Reaction-time hand movement / Audio-initiated vocalization / Recognition learning
Research Abstract

Field potentials were recorded with electrodes implanted in various cortical areas while a monkey was learning reaction-time hand movements with complex tone. When cortical surface-negative, depth-positive (s-N,d-P) potential (at a latency of about 80 ms after stimulus) appeared in the rostral bank of the inferior limb of the arcuate sulcus of the left cerebral hemisphere, and became gradually larger, the monkey began to respond to stimulus with movement (recognition learning). As the potential in the prefrontal cortex and the cerebellar-mediated potential in the motor cortex gradually increased with further training, the movement became quicker and more skillful. Three monkeys achieved the movement with complex tone in shorter training days than the movement with pure tone. Cortical field potentials were recorded during learning processes of visuo-initiated hand movements, and analized. It was found that as-N,d-P potential (at about 80 ms after stimulus) in the rostral bank of the inferior limb of the arcuate sulcus of the left cerebral hemisphere was related to recognition learning, and that a s-N,d-P potential (at a latency of about 80 ms after stimulus) in the rostral bank of the arcuate sulcus in the right cerebral hemisphere was motivation-dependent activity. A s-N,d-P potential (at about 70 ms after stimulus) was also recorded in the rostral bank of the inferior limb of the arcuate sulcus of the left cerebral hemisphere in audio-initiated vocalization. There facts suggest that dorsolateral prefrontal cortex is involved in motivational functions as well as in cognitive functions.
The cortical activity related to recognition learning is s-N,d-P potential, and is considered to be a superficial thalamo-cortical response. Morphological studies suggest that the VAmc thalamic nuclei are related to initiation of the activity. There was hardly any change in the activity before and after cerebellectomy or basal ganglia cooling.

  • Research Products

    (88 results)

All Other

All Publications (88 results)

  • [Publications] Gemba H: "Cortical field potentials preceding vocalization and influences of cerebellar hemispherectomy upon them in monkeys." Brain Res.697. 143-151 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "Field potential change in the prefrontal cortex of the left hemisphere during learning processes of reaction time hand movement with complex tone in the monkey." Neurosci.Lett.190. 93-96 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "Temporary compensation of the somatosensory cortex for motor cortical activity." Jpn.J.Physiol.45 Suppl.1. S172 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "Functional differences between the prefrontal cortices of left and right cerebral hemispheres in the monkey." Electroenceph.clin.Neurophysiol.97. S237 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "背外側前頭前野と情動" J.Physiol.Soc.Japan. 57. 488 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 足立 靖: "縦隔原発絨毛癌の1剖検例" 胸部外科. 48. 829-831 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "随意運動における情動と大脳皮質フィールド電位" Jpn.J.EEG EMG. 23. 150-151 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki K.: "Motor speech centres in the frontal cortex." Neurosci.Res.22. 245-248 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木 和夫: "脳磁場および脳電場計測による前頭連合野の動態研究" J.Physiol.Soc.Japan. 57. 13-21 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木 和夫: "脳磁場計測による運動性言語中枢同定の試み" J.Physiol.Soc.Japan. 57. 489 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikeda M.: "Enkephalin-immunoreactive fastigial neurons in the rat cerebellum project to upper cervical cord segments." Brain Res.690. 225-230 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Adachi Y.: "Effect of bone marrow transplantation on anti-phospholipid antibody syndrome in murine lupus mice." Immunobiol.192. 218-230 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "Influences of emotion upon parotid secretion in human." Neurosci Lett. 211. 159-162 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugihara A: "Expression of CD45-restricted form B in (NZW×BXSB) F1 and MRL/Mp-lpr/lpr mice." Autoimmunity. 24. 237-246 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "Emotional state in man and salivary flow rate and heart rate." Neurosci Res Suppl. 20. S263 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "Parotid salivary flow rate and emotion in humans." Jap J Physiol Suppl. 46. S149 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "CNVの発生源と生理学的意義." 脳波と筋電図. 24. 106 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kyuhou S: "Cerebello-thalamo-cortical projections onto the ventral part of the frontal cortex in monkeys." Jap J Physiol Suppl. 46. S139 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木 和夫: "時間計測に伴う前頭知的シ-タ波" 日本生体磁気学会誌. 9. 178-181 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki K: "MEG study on frontal mental theta wave induced on measuring time in human subject." Neurosci Res Suppl. 20. S263 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki K: "Studies on integrative functions of the human frontal association cortex by use of MEG." Cognitive Brain Res. 5. 165-174 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki K: "Studies on integrative functions of the human frontal association cortex by use of MEG." Electroenceph Clin Neurophysiol Suppl. 47. 181-190 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "Autonomic nerve responses and emotion in humans." Neurosci Res Suppl. 21. 2412 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsushita M: "Differential roles of astrocyte and microglia in development of hepatic encephalopathy." Neurosci Res Suppl. 21. 2908 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "Q&A「天気により気分が変わるのはどのような生理機序か」" Clinical Neuroscience. 15. 111 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "「特徴抽出」困難な時代に有用なサル学." 学術の動向-JSCニュース. 2. 47-49 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "CNVの発生源." 臨床脳波. 39. 239-244 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "広くて大きい“生理学の椅子",日本生理学雑誌巻頭言." 日本生理学雑誌. 59. 83-84 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "生理学の動向と展望「生命への統合」." 日本生理学雑誌. 59. 345-369 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "唾液分泌速度と感情評価." 日本唾液腺学会誌. 38(印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kyuhou S: "Cerebello-cerebral projections to the ventral part of the frontal cortex of the macaque monkey." Neurosci Lett. 230. 101-104 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "Motivation-dependent activity in the dorsolateral part of the prefrontal cortex in the monkey." Neurosci Lett. 230. 133-136 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "Cortical field potentials preceding vocalization in monkeys." Acta Otolarygol Suppl. 532. 96-98 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuzaki R: "Pontine neurons which relay projections from the superior colliculus to the posterior vermis of the cerebellum in the cat:distribution and visual properties" Neurosci Lett. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "EPIC XI(The XIth International Conference on Event-Related Potentials of the Brain) (Abstracts)" 1 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "岡崎国立共同研究機構生理学研究所年報 第16巻" 岡崎国立共同研究機構生理学研究所, 4 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H.: "Fourth IBRO World Congress of Neuroscience(Abstracts)" Rapid Communications, 1 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木和夫: "岡崎国立共同研究機構生理学研究所年報 第16巻" 岡崎国立共同研究機構生理学研究所, 5 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 南部篤: "岡崎国立共同研究機構生理学研究所年報 16巻" 岡崎国立共同研究機構生理学研究所, 1 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木和夫: "平成6年度研究報告書" 厚生省運動失調症調査研究班, 4 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nambu A: "Biomagnetism" Baumgartner C et al, 4 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kyuhou S: "Biomagnetism" L.Deecke et al., 5 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki K.: "Biomagnetism" L.Deecke et al., 4 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okada Y.: "Fourth IBRO World Congress of Neuroscience(Abstracts)" Rapid Communications, 1 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki K: "Integrative and Molecular Approach to Brain Function" Ito M & Miyashita Y, 12 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki K: "Perception,Memory and Emotion" Ono T et al, 12 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "前頭葉-神経科学の基礎と臨床V-" 板倉徹、前田敏博, 21 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki K: "Recent Advances in Clinical Neurophysiology Elsevier" Kimura J & Shibasaki H, 7 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "岡崎国立共同研究機構生理学研究所年報 17巻" 岡崎国立共同研究機構生理学研究所, 1 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "Recent Advances in Event-related Brain potential Research Elsevier" Ogura C et al, 7 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "事象関連電位と神経情報科学の発展" 丹羽真一、鶴紀子, 15 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kyuhou S: "Biomagnetism Elsevier" Wood CC et al(in press), (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kyuhou S.: "Biomag96(Tenth International Conference on Biomagnetism) (Abstracts)" 1 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 久寳真一: "脳磁気科学-SQUID計測と医学応用-" 原宏、栗城真也, 5 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "岡崎国立共同研究機構生理学研究所年報 18巻" 岡崎国立共同研究機構生理学研究所, 1 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba H: "Cortical field potentials preceding vocalization and influences of cerebellar hemispherectomy upon them in monkeys." Brain Res. 697. 143-151 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Field potential change in the prefrontal cortex of the left hemisphere during learning processes of reaction time hand movement with complex tone in the monkey." Neurosci Lett. 190. 93-96 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Adachi Y: "Effect of bone marrow transplantation on anti-phospholipid antibody syndrome in murine lupus mice." Immunobiol. 192. 218-230 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikeda M: "Enkephalin-immunoreactive fastigial neurons in the rat cerebellum project to upper cervical cord segments." Brain Res. 690. 225-230 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nambu A: "Magnetic fields in the cerebral cortex associated with visually initiated finger movements in human subjects." Biomagnetism. 141-144 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki K: "Motor speech centers in the frontal cortex." Neurosci Res. 22. 245-248 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki K: "Prefrontal activity on no-go decision." Biomagnetism. 274-277 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kyuhou S: "Characteristic of the magnetic signals of hippocampus in the guinea pig." Biomagnetism. 818-822 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Cortical activation on vocalization in monkeys." Fourth IBRO World Congress of Neuroscience Abstracts. 473 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Cortical field potentials and emotion in the monkey." The XIth International Conference on Event-Related Potentials of the Brain. 30. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Functional differences between the prefrontal cotices of left and right cerebral hemispheres in the monkey." Electroenceph Clin Neurophysiol. 97. S237 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Temporary compensation of the somatosensory cotex for motor cortical activity." Jpn J Physiol Suppl. 45. S172 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okada Y: "Neuromagnetic study on the guinea pig hippocampal slice." Forth IBRO World Congress of Neuroscience Abstracts. 481 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki K: "Magnetoencephalographical study on cortical theta waves induced during concentrated mental work and emotional excitation in human subjects." Perception, Memory and Emotion. 453-464 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki K: "Integrative functions of the human frontal association cortex studied with MEG." Integrative and Molecular Approach to Brain Function. 303-314 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Influences of emotin upon parotid secretion in human." Neurosci Lett. 211. 159-162 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Cortical field potentials and emotion in the monkey." Recent Advances in Event-related Brain Potential Research. 327-333 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki K: "Integrative functions of the human frontal association cortex as studied with MEG." Recent Advances in Clinical Neurophysiology. 893-899 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki K: "Studies on integrative functions of the human frontal association cortex by use of MEG." Electroenceph Clin Neurophysiol Suppl. 47. 181-190 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki K: "Studies on integrative functions of the human frontal association cortex by use of MEG." Cognitive Brain Res. 5. 165-174 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugihara A: "Expression of CD45-restricted from B in (NZW*BXSB) F1 and MRL/Mp-Ipr/Ipr mice." Autoimmunity. 24. 237-246 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Emotional state in man and salivary flow rate and heart rate." Neurosci Res Suppl. 20. S263 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Parotid salivary flow rate and emotion in humans." Jpn J Physiol Suppl. 46. S149 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kyuhou S: "Cerebello-thalamo-cortical projections onto the ventral part of the frontal cortex in monkeys." Jpn J Physiol Suppl. 46. S139 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki K: "MEG study on frontal mental theta wave induced on measuring time in human subject." Neurosci Res Suppl. 20. S263 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kyuhou S: "Magnetoencephalographic study on cerebral cortical activities related to speech." Tenth International Conference on Biomagnetism, Biomag96 Abstracts. 73 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kyuhou S: "Cerebello-cerebral projections to the ventral part of the frontal cortex of the macaque monkey." Nekurosci Lett. 230. 101-104 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Motivation-dependent activity in the dorsolateral part of the prefrontal cortex in the monkey." Neurosci Lett. 230. 133-136 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Cortical field potentials preceding vocalization in monkeys." Acta Otolarygol. 532. 96-98 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuzaki R: "Pontine neurons which relay projections from the superior colliculus to the posterior vermis of the cerebellum in the cat : distribution and visual properties." Neurosci Lett. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba H: "Autonomic nerve responses and emotion in humans." Neurosci Res Suppl. 21. 2412 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsushita M: "Differential roles of astrocyte and microglia in development of hepatic encephalopathy." Neurosci Res Suppl. 21. 2908 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kyuhou S: "Magnetoencephalographic study on cerebral cortical activities related to speech." Biomagnetism. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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