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1996 Fiscal Year Final Research Report Summary

Cerebello-cerebral projections onto the vocalization-related cortical areas in the monkey.

Research Project

Project/Area Number 07680903
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 神経・脳内生理学
Research InstitutionKansai Medical University

Principal Investigator

KYUHOU Shinichi  Kansai Medical University, Dept.Physiology, Lecturer, 医学部, 講師 (60195394)

Co-Investigator(Kenkyū-buntansha) GEMBA Hisae  Kansai Medical University, Dept.Physiology, Professor, 医学部, 教授 (00108987)
Project Period (FY) 1995 – 1996
KeywordsVocalization / Cerebellum / Broca's area / Thalamus / Monkey / Motor cortex / Sonagram / Cortical field potential
Research Abstract

Prior to self-paced vocalization, surface-negative and depth-positive (s-N,d-P) slow potentials were recorded in the face motor area and the ventral part of premotor area (PMv) in monkeys. The slow potentials prior to vocalization were eliminated after cerebellar hemispherectomy on the contralateral side. Under chloralose anesthesia, stimulation of the lateral and interposed cerebellar nucleus induced superficial thalamo-cortical responses composed of s-N,d-P potentials in the face motor area and the PMv on the contralateral side. Stimulation of the medial nucleus did not produce a response in these areas. To investigate the thalamic relay stations of the cerebello-cerebral projections, fluorescent dyes (Fast Blue, Diamidino Yellow) were injected respectively into the face motor area and PMv, while WGA-HRP was injected into the cerebellar nuclei. Extensive overlapping of the distributions of the retrogradely labeled thalamocortical neurons and the anterogradely labeled cerebellothalamic axon terminals was found in the VPLo after injection of the tracer into the face motor area and also in the area X after injection into the PMv. These results indicate that the projections from the cerebellar nuclei to the face motor and the PMv are relayd mainly in the VPLo and area X,respectively.
Monkeys were trained to vocalize in responses to a species-specific call (audio-initiated vocalization). A sonagraphic analysis on the vocalizations demonstrated that the cerebellar hemispherectomy influenced upon the acoustic structures ; new components of vocal tone (frequency around 4kHz) appeared after the operation.
The present studies demonstrated the pathways of the cerebellar projection onto the vocalization-related cortical areas. The disorganization of the acoustic structures of monkey calls after neocerebellar lesions suggested that the neocerebelo-thalamo-cortical projections are involved in the vocal control.

  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] K.Sasaki: "Motor speech centres in the frontal cortex.21GC01:Neuroscience Res." 22. 245-248 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Gemba: "Cortical field potentials preceding vocalization and influcnces of cerebellar hemispherectomy upon them in monkeys." Brain Res.697. 143-151 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Gemba: "Field potential change in the prefrontal cortex of the left hemisphere during learning processes of reaction time hand movement with complex tone in the monkey." Neurosci.Lett.190. 93-96 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Gemba: "Influences of emotion upon parotid secretion in human." Neurosci.Lett.211. 159-162 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.C.Okada: "Neuromagnetic study on the guinea pig hippocampal slice." Fourth IBRO World Congress of Neurosciecnce Abstracts. 481 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kyuhou: "Cerebello-thalamo-cortical projections onto the ventral part of the frontal cortex in monkey." Jpn.J.Physiol.46. S139- (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Gemba: "Protid salivary flow rate and emotion in humans." Jpn.J.Physiol.46. (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Gemba: "Emotional state in man and salivary flow rate and heart rate." Neurosci Res. 20. S263- (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木和夫: "脳磁場および脳電場計測による前頭連合野の動態研究." J Physiol Soc Japan. 57. 13-21 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番央恵: "聴覚始動性の行動と大脳皮質フィールド電位." 岡崎国立共同研究機構生理学研究所年報.17. 365- (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番央恵: "付随陰性電位変動(CNV)の発現機序に関する研究." 岡崎国立共同研究機構生理学研究所年報.16. 219- (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番央恵: "運動性言語中枢に関する脳磁場計測." 岡崎国立共同研究機構生理学研究所年報.16. 324- (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番央恵: "発声の中枢神経機序." 岡崎国立共同研究機構生理学研究所年報.16. 368- (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木和夫: "脳磁場計測による運動性言語中枢の研究." 岡崎国立共同研究機構生理学研究所年報.16. 78-82 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 南部篤: "しりとり単語想起に伴う前頭葉皮質の脳磁場活動." 岡崎国立共同研究機構生理学研究所年報.16. 82-83 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番央恵: "CNVの発生源と生理学的意義." 脳波と筋電図. 24. 106- (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kyuhou: "Biomagnetism" Wood CC et al(in press), (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 久寳 真一: "脳磁気科学-SQUID計測と医学応用-" 原 宏、栗城真也, 5 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Gemba: "Recent Advances in Event-related Brain potential Research Elsevier" Ogura C et al, 7 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Sasaki: "Recent advances in clinical neurophysiology." J.Kimura and H.Shibasaki, 7 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Nambu: "Biomagnetism" L.Deecke et al., 4 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木和夫: "厚生省運動失調症調査研究班平成6年度研究報告書" 脳磁場計測(MEG)による運動性言語中枢の研究., 3 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kyuhou: "Biomagnetism" 5 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Sasaki: "Biomagnetism" L.Deecke et al, 4 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Sasaki: "Motor speech centers in the frontal cortex." Neuroscience Res. 22. 245-248 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kyuhou: "Characteristics of the magnetic signals of hippocampus in the guinea pig." Biomagnetism. (eds.) L.Deecke et al., Elsevier, Amsterdam. 818-822 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sasaki: "Prefrontal activity on no-go decision" Biomagnetism. (eds.) L.Deecke et al., Elsevier, Amsterdam. 274-277 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Nambu: "Magnetic fields in the cerebral cortex associated with visually initiated finger movements in human subjects." Biomagnetism. (eds.) L.Deecke et al., Elsevier, Amsterdam. 274-277 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Gemba: "Cortical field potentials preceding vocalization and influences of cerebellar hemispherectomy upon them in monkeys" Brain Res.697. 143-151 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Gemba: "Field potential change in the prefrontal cortex of the left hemisphere during learning processes of reaction time hand movement with complex tone in the monkey." Neurosci.Lett.190. 93-96 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.C.Okada: "Neuromagnetic study on the guinea pig hippocampal slice." Fourth IBRO World Congress of Neuroscience Abstracts. 481. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Gemba: "Influences of emotion upon parotid secretion in human." Neurosci.Lett.211. 159-162 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kyuhou: "Cerebello-thalamo-cortical projections onto the ventral part of the frontal cortex in monkeys" Jpn.J.Physiol.Suppl.46. S139 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Gemba: "Protid salivary flow rate and emotion in human" Jpn.J.Physiol.Suppl.46. S149 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Gemba: "Emotional state in man and salivary flow rate and heart rate." Neurosci Res. Suppl 20. S263 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sasaki: Integrative functions of the human frontal association cortex as studied with MEG.Recent advances in clinical neurophysiology Elsevier Amsterdam. J.Kimura and H.Shibasaki (eds), 893-899 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Gemba: Cortical field potentials and emotion in the monkey. Recent Advances in Eventrelated Brain Potential Reserch, Elsevier, Amsterdam. C.Ogura et al. (eds), 327-333 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kyuhou: Magnetoencephalographic study on cerebral cortical activities related to speech. Biomagnetism. C.C.Wood et al. (eds.) (in press), (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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