1996 Fiscal Year Final Research Report Summary
Cerebello-cerebral projections onto the vocalization-related cortical areas in the monkey.
| Project/Area Number |
07680903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
神経・脳内生理学
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| Research Institution | Kansai Medical University |
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Principal Investigator |
KYUHOU Shinichi Kansai Medical University, Dept.Physiology, Lecturer, 医学部, 講師 (60195394)
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| Co-Investigator(Kenkyū-buntansha) |
GEMBA Hisae Kansai Medical University, Dept.Physiology, Professor, 医学部, 教授 (00108987)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Vocalization / Cerebellum / Broca's area / Thalamus / Monkey / Motor cortex / Sonagram / Cortical field potential |
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| Research Abstract |
Prior to self-paced vocalization, surface-negative and depth-positive (s-N,d-P) slow potentials were recorded in the face motor area and the ventral part of premotor area (PMv) in monkeys. The slow potentials prior to vocalization were eliminated after cerebellar hemispherectomy on the contralateral side. Under chloralose anesthesia, stimulation of the lateral and interposed cerebellar nucleus induced superficial thalamo-cortical responses composed of s-N,d-P potentials in the face motor area and the PMv on the contralateral side. Stimulation of the medial nucleus did not produce a response in these areas. To investigate the thalamic relay stations of the cerebello-cerebral projections, fluorescent dyes (Fast Blue, Diamidino Yellow) were injected respectively into the face motor area and PMv, while WGA-HRP was injected into the cerebellar nuclei. Extensive overlapping of the distributions of the retrogradely labeled thalamocortical neurons and the anterogradely labeled cerebellothalamic axon terminals was found in the VPLo after injection of the tracer into the face motor area and also in the area X after injection into the PMv. These results indicate that the projections from the cerebellar nuclei to the face motor and the PMv are relayd mainly in the VPLo and area X,respectively.
Monkeys were trained to vocalize in responses to a species-specific call (audio-initiated vocalization). A sonagraphic analysis on the vocalizations demonstrated that the cerebellar hemispherectomy influenced upon the acoustic structures ; new components of vocal tone (frequency around 4kHz) appeared after the operation.
The present studies demonstrated the pathways of the cerebellar projection onto the vocalization-related cortical areas. The disorganization of the acoustic structures of monkey calls after neocerebellar lesions suggested that the neocerebelo-thalamo-cortical projections are involved in the vocal control.
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