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1996 Fiscal Year Final Research Report Summary

Endothelial Cell-Pericyte Interdigitation is Mediator of Angiogenesis?

Research Project

Project/Area Number 07806042
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionAzabu University

Principal Investigator

WAKUI Shin  Azabu University School of Veterinary Medicine Associate Professor, 獣医学部・女給図 (40201157)

Project Period (FY) 1995 – 1996
Keywordsangiogenesis / endothelial cell and pericyte interdigitation / TGFbeta / VEGF
Research Abstract

Under in vitro conditions pericytes have been shown to inhibit the proliferation of cultured endothelial cells. This inhibitory effect of pericytes appeared to be mediated by a activated form of TGFbeta depended on the formation of cell-cell contacts between endothelial cells and pericytes, and is mediated by uPA-plasmin activity. However, the endothelial cell and pericyte contacts during coculture have been detected only light microscopy, and the detailed structures of these contact has been unresolved. Meantime, in vivo angiogenesis, immature capillaries possess many endothelial cell and pericyte contacts, such as endothelial cell-pericyte interdigitations (EPI). I have demonstrated that the number of EPI increases with ongoing maturation of newly formed capillaries, and suggested pericytes do indeed to inhibit endothelial cells proliferation in a manner requiring the physical proximity effort by the EPI.The present study revealed in angiogenic sites that uPA expression was preferentially in EPI and TGFbeta was present throughout the stroma including EPI.These findings suggest a functional interplay between uPA expression and endothelial cells maturation, and support the idea that endothelial cells proliferating inhibitor function by TGFbeta activated by uPA during angiogenesis to mediate at EPI.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Wakui,S.ct al.: "Nuclcar body appearance rate in canine Sertoli cell tumors." Journal of Submicroscopic Cytology and Pathology. 27. 275-279 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi,H.et al.: "Prevalence of androgen receptor gene mutation in latent prostatic carcinoma" Cancer Research:. 55. 1621-1624 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wakui,S.et al.: "Immunoytochemical localization of epidermal growrh factor receptor in the rhesus" Anatomia Histologia Embryologia. 25. 109-111 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wakui,S.et al.: "Epithelial glycoconjugates of canine efferent ductules" Journal of Anatomy. 188. 541-546 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mangold,K.et al: "P16 (CDKN2/MTSI) tumor suppressor dleions are present in prostatic carcinoma" Journal of Urology. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wakui,S.et al.: "Testieular efferent ductulc cyst of a dog." Veterinary pathology. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wakui,S.et al.: "Microcirculation Annual 1995" Nihon lgakukan, 207 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wakui, S.Yokoo K.Furusato, M.Yokoyama, Y.Ushigome, S.Aizawa, S.: "Nuclear body appearance rate in canine Sertoli cell tumors." Journal of Submicroscopic Cytology and Pathology. 27. 275-279 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, H.Furusato, M.Allsbrook, WC.Nishii, H.Wakui, S.Barrett, JC.Boyd, J.: "Prevalence of androgen receptor gene mutation in latent prostatic carcinoma from Japanese man." Cancer Research. 55. 1621-1624 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wakui, S.Furusato, M.Sasaki, S.Masaoka, T.Ushigome, S.Aizawa, S.: "Immunocytochemical localization of epidermal growth factor receptor in the rhesus monkey prostate." Anatomia Histologia Embryologia. 25. 109-111 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wakui, S.Furusato, M.Takahashi, H.Motoya, M.Aizawa, S.Ushigome, S.: "Epithelial glycoconjugates of canine efferent ductules" Journal of Anatomy. 188. 851-546 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mangold, K.Takahashi, H.Brandigi, C.Wada, T.Wakui, S.Furusato, M.Boyd, J.Candler, F.Allsbrook, W.: "P16 (CDKN2/MTSl)tumor suppressor deletions are present in prostatic carcinoma in Japanese but not Americans" Journal of Urology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wakui, S.Furusato, M.Yokoo, K.Ushigome, S.: "Testicular efferent ductule cyst of a dog." Veterinary Pathology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wakui, S.Furusato, M.Sasaki, S.Ohshige, H.Ushigome, S.: (Editors : Tsuchiya M., Asano M., Kamiya A) : Microcirculation Annual '1995. Nihon Igakukan, (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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