1996 Fiscal Year Final Research Report Summary
Localization and function of acidic fibroblast growth factor in adrenal gland
| Project/Area Number |
07807002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
TOOYAMA Ikuo Shiga University of Medical Science Associate Professor., 分子神経生物学研究センター, 助教授 (20207533)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Acidic fibroblast growth factor / FGF / receptor / hormone / adrenal gland |
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| Research Abstract |
Fibroblast growth factor (FGF) is a family of peptides which promote the proliferation of mesodermal tissues and neuroectodermal cells. Acidic fibroblast growth factor (aFGF ; FGF-1) and basic fibroblast growth factor (bFGF ; FGF-2) were first members of this family that were purified and well characterized. The distribution of aFGF was originally through to be limited to the central nervous system such as the brain and retina. The present studies however, have demonstrated that aFGF mRNA is richly exoressed in the adrenal medulla, and aFGF peptide is localized in adrenergic neurons. Moreover, FGF receptor-1 has been detected in the adrenal cortex. Administration of FGF has upragulated the secretion of adrenocortical steroid hormones. These results suggest that aFGF may regulate the secretion of adrenal steroids as a local hormone.
In addition, aFGF exogenously administered has several effects on physiological behaviors. These include supression of food intake and the improvement of memory and learning. Taken together, it is strongly suggested that aFGF may exert its biological activity, at least partly, as a hormone.
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[Publications] Y Oomura, K Sasaki, A Li, H Yoshii, Y Fukata, H Yago, H Kimura, I Tooyama, K Hanai, Y Nomura, N Yanaihara: "Protection against impairment of memory and immunoreactivity in senescence-accelerated mice by acidic fibroblast growth factor." Ann New York Acad Sci. 786. 337-347 (1996)
Description
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