1996 Fiscal Year Final Research Report Summary
The possible role of Remnant Lipoproteins as a risk factor for Sudden Cardiac Death
| Project/Area Number |
07807050
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Tokai University |
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Principal Investigator |
TAKEICHI Sanae Tokai University Dept., Forensic Medicine, Professor, 医学部, 教授 (20035497)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Katsuyuki Otsuka America, Phermaceutical.Inc., Director, メリーランド オフィス・オブ・クリニカルリサーチ, プロジェクトリーダー
SAITO Takeshi Tokai University Dept., Forensic Medicine, Assistant, 医学部, 助手 (30266465)
YUKAWA Nobuhiro Tokai University Dept., Forensic Medicine, Lecturer, 医学部, 講師 (30240154)
OSAWA Motoki Tokai University Dept., Forensic Medicine, Associate Professor, 医学部, 助教授 (90213686)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Remnant-Like Particles (RLPs) / RLP-TG / RLP-C / Sudden Cardiac Death / Apo-protein E / Coronary atherosclerosis / Hyperlipoproteinemia / Thrombogenesis |
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| Research Abstract |
Postmortem plasma lipid and lipoprotein analyzes were conducted in two groups of Japanese subjects who died suddenly and unexpectedly due to cardiac (n=93) or non-cardiac (n=26) cases. No individuals in either group had a significant medical or cardiac history. In this study, we measured plasma total cholesterol, triglyceride, VLDL-cholesterol, LDL-cholesterol, HDL-cholesterol, and especially lipoprotein remnants. Triglyceride and apo E rich remnant-like particles (RLP) have been studied here as a possible risk factor for sudden cardiac death. Plasma RLP-cholesterol (RLP-C) and RLP-triglyceride (RLP-TG) values in relation to the progression of coronary atherosclerosis and to the risk for sudden cardiac death were also studied. The receiver-operating characteristic curve (ROC) analysis showed that RLP-TG was the most significant risk factor for sudden cardiac death among the lipids and lipoproteins and RLP-C was the greatest predictor for coronary atherosclerosis. HDL-C and LDL-C levels were within normal limits in the majority of the cases and did not appear to relate to the sudden cardiac death. Apo E phenotyping was performed for the detection of genetic back ground in the lipid metabolism. The frequency of Apo E 3/3 (wild type) phenotype which closely relates with the remnant metabolism was significantly reduced in the sudden cardiac death group. These results suggest that elevated RLP-C and RLP-TG levels are more prevalent in coronary atherosclerosis and sudden cardiac death, and may be better predictors of these events.
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[Publications] Schneider WJ,Kovanen PT,Brown MS,Goldstein JL,Utermann G,Weber W,Havel RJ,Kotite L,Kane JP,Innerarity TL,Mahley RW: "Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows." J Clin Invest. 68. 1075-1085 (1981)
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「研究成果報告書概要(欧文)」より
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[Publications] Nakajima K,Saito T,Tamura A,Suzuki M,Nakano T,Adachi M,Tanaka A,Tada N,Nakamura H,Campos E,Havel RJ: "Cholesterol in remnant-like lipoproteins in human serum using monoclonal anti apo B-100 and anti apo A-I immunoaffinity mixed gels." Clin Chim Acta. 223. 53-71 (1993)
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「研究成果報告書概要(欧文)」より
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