1996 Fiscal Year Final Research Report Summary
A study on altered immune function in rheumatoid arthritis through disfunction of transcription factor
| Project/Area Number |
07807051
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | University of Tokyo |
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Principal Investigator |
INOUE Tetsufumi University of Tokyo, Department of Medicine, Associate Professor, 医学部・附属病院, 講師 (30092141)
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| Co-Investigator(Kenkyū-buntansha) |
SAWADA Tetsuji University of Tokyo, Department of Medicine, Clinical Fellow, 医学部・附属病院, 医員 (50235470)
TOHMA Shigeto University of Tokyo, Department of Medicine, Assistant Professor, 医学部・附属病院, 助手 (50207528)
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| Project Period (FY) |
1995 – 1996
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| Keywords | apoptosis / transcripton factor / reactive oxygen species / anti-rheumatic drugs |
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| Research Abstract |
NF-KB is known to play a important role in the regulation of macrophages. It is partially regulated by redox mechanism. In this study, anti-rheumatic drugs, D-penicillamine, bucillamine, auranofine increased the amount of intracellular reactive oxygen species of THP-1, moreover, downregulated their proliferation. It was suggested that these drugs suppressed the activity of NF-KB through the increase of reactive oxygen species.
Possibility of the apoptosis induction through the increase of intracelllar reactive oxygen species was also studied. Bucillamine first induced the production of reactive oxygen species and the change of membrane permeability of THP-1. Consequently, apoptosis of THP-1 turned out. It was suggested that bucillamine suppressed the proliferation of synovial cells in rheumatoid arthritis through the induction of apoptosis.
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[Publications] Shinohara, S., Sawada, T., Nishioka, Y., Tohma, S., Kisaki, T., Inoue, T., et. al.: "Differential expression of Fas antigen and Bcl-2 protein on CD4^+ T cells, CD8^+ T cells and monocytes." Cellular Immmunol.163. 303-308 (1995)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Sawada, T., Hashimoto, S., Hurukawa, H., Tohma, S., Inoue, T., Ito, K.: "Generation of reactive oxygen species is required for bucillamine, a novel anti-rheumatic drug, to induce apoptosis in concert with copper." Immunopharmacology. 35 (3). 195-202 (1996)
Description
「研究成果報告書概要(欧文)」より
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