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1997 Fiscal Year Final Research Report Summary

Expression fo estrogen receptor in human articular chondrocytes.

Research Project

Project/Area Number 07807139
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionShiga University of Medical Science

Principal Investigator

USHIYAMA Toshio  Shiga University of Medical Science School of Medicine, Assistant, 医学部, 助手 (10263055)

Co-Investigator(Kenkyū-buntansha) INOUE Koji  Shiga University of Medical Science School of Medicine, Lecturer, 医学部, 講師 (80213156)
Project Period (FY) 1995 – 1997
Keywordschondrocyte / estrogen receptor / IL-6 / TGF-beta
Research Abstract

1)Expression of sex hormone receptors in human articular chondrocytes
We extracted human articular chondrocyte mRNA during joint surgey-Using RT-PCR method and Northern blotting method, we demonstrated the expressions of the estrogen, progesterone and androgen receptor gene.
2)Cytokine releases by estradiol in cultured human articular chondrocytes
We added estadiol to the culture medium of cultured human articular chondrocytes and examined releases of IL-1, IL-4, IL6, TNFalpha and TGFbeta. We demonstrated estradiol increases IL-6 and TGFbeta releases.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Koji Inoue, Tochio Ushiyama, Yuichiro Kim et al.: "Increased rate of hystereetomy in women undergoing surgery for osteodrthritis of the knee." Osteoarthritis Cart. 22. 205-209 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshio Ushiyama, Koji Inoue, Junichi Nichioka at al.: "Expression of estrogen receptor related protein (p29) and estradiol binding in human artyritic synpouim." J Rheumato 1. 22. 421-426 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshio Ushiyama, Hisao Ueyama, Koji Inoue et al.: "Estrogen receptor gene polymorphism and generalized osteoarthritis" J Rheumato 1. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 牛山 敏夫 西岡 淳一: "Generalized OA-位置づけと解説" リウマチ'97. 39-47 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 牛山 敏夫: "性ホルモンとRA" リウマチセミナーVIII. 26-32 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshio Ushiyama, Hisao Ueyama, Koji Inoue, Junichi Nishioka, Iwqao Ohkubo, Sinsuke Hukuda: "Estrogen receptor gene polymorphism and generalized osteoarthritis." J Rheumatol. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toshio Ushiyama, Koji Inoue, Junichi Nishioka: "Expression of estrogen receptor-related protein (p29) and estradiol binding in human arthritic synovium." J Rheumatol. 22. 421-426 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koji Inoue, Hideto Nakajima, Toshio Ushiyama, Sinsuke Hukuda: "Immunohistochemical identification of chondrocalcin in synovial chondromatosis." Osteoarthritis Cart. 4. 287-288 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koji Inoue, Toshio Ushiyama, Yuichiro Kim, Kanji Shichikawa, Junichi Nishioka, Sinsuke Hukuda: "Increased rate of hysterectomy in women who undergo surgery for severe osteoarthritis of the knee and the spine." Osteoarthritis Cart. 3. 205-209 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koji Inoue, Toshio Ushiyama, Katsuhiro Hori, Sinsuke Hukuda: "Increased level of chondrocalcin in a patient with synovial osteochondromatosis" Osteoarthritis Cart.2. 71-73 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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