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1996 Fiscal Year Final Research Report Summary

Histological study for neoplastic potential of endometriosis

Research Project

Project/Area Number 07807154
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionSHINSHU UNIVERSITY

Principal Investigator

NAKAYAMA Kuniaki  Shinshu university Hospital, Resercher Associate, 医学部・附属病院, 助手 (10217929)

Co-Investigator(Kenkyū-buntansha) NIKAIDO Toshio  Shinshu university Hospital, Assistant Professor, 医学部・附属病院, 講師 (50180568)
FUJII Shingo  Shinshu university, School of medicine, Professor, 医学部, 教授 (30135579)
Project Period (FY) 1995 – 1996
KeywordsEndometriosis / estrogen receptor / progesterone receptor / cyclin / cyclin-dependent kinase / Ki-67 / p53 / neoplastic potential
Research Abstract

To know the difference of growth control mechanism between endometriosis and the endometrium, expression of sex steroid receptors (estrogen receptors : ER,Progesterone receptors : PR), Ki-67, Proliferating cell nuclear antigen (PCNA), G1 cell cycle regulatory molecules (cyclins, cyclin-dependent kinases : CDKs), and tumor suppressor gene product (p53) was analyzed in these tissues. Immunohistochemically, ER, PR, cyclin E, cyclin A,cyclin B,cdk4, cdk2, cdc2, and p53 were stained in 18 endometriotic lesions from 10 patients and in their corresponding normal eutopic endometria. Of the 10 patients, 6 were in the proliferative and 4 were in the secretory phase of the menstrual cycle. The normal eutopic endometrial glands showed the expression of both ER and PR in the proliferative phase and down-expression of these receptors in the secretory phase, and they were negative for p53. Of 18 endometriotic lesions, 13 exhibited both ER and PR staining irrespective of the phases of the menstrual cycle. While 4 showed negative staining for both ER and PR in the epithelial cells and p53 positive cells were intermingled. The expression of Ki-67, PCNA,cyclins and CDKs was observed in both the endometriotic lesions and normal endometria. However, compare to the normal endometrium, PCNA,cyclin E,cyclin A and cdk4 were frequently expressed in the endometriotic lesions of the secretory phase. The expression of sex steroid receptors and G1 cell cycle regulatory molecules in endometriotic lesions was not coordinated with that of the eutopic endometrium. The endometriotic lesions, which showed overexpression of p53 and negative expression of ER and PR,might be in a process of neoplastic transformation.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Tanri Shiozawa, et al.: "Relationship between the expression of cyclins/cyclin-dependent kinases and sex-steroid receptors/Ki67 in normal human endometrial glands and stroma during the menstrual cycle." Molecular human reproduction. 2 (10). 745-752 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shuan-fang Li, et al.: "Stepwise abnormality of sex steroid hormone receptors. tumor suppressor gene products (p53 and Rb). and cyclin E in uterine endometrioid carcinoma." Cancer. 77 (2). 321-329 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toshihiko Toki, et al.: "Proliferative activity of postmenopausal endometriosis : A histopathologic and immunocytochemical study." International Journal of Gynecological Pathology. 15 (1). 45-53 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanri Shiozawa, Shuan-fang Li, Kuniaki Nakayama, Toshio Nikaido, Shingo Fujii.: "Relationship between the expression of cyclins/cyclin-dependent kinases and sex-steroid receptors/Ki67 in normal human endometrial glands and stroma during the menstrual cycle." Molecular human reproduction. 2(10). 745-752 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shuan-fang Li, Tanri Shiozawa, Kuniaki Nakayama, Toshio Nikaido, Shingo Fujii: "Stepwise abnormality of sex steroid hormone receptors, tumor suppressor gene products (p53 and Rb), and cyclin E in uterine endometrioid carcinoma." Cancer. 77(2). 321-329 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toshihiko Toki, Akiko Horiuchi, Suan-fang Li, Kuniaki Nakayama, Steven G.Silverberg, Shingo Fujii.: "Proliferative activity of postmenopausal endometriosis : A histopathologic and immunocytochemical study." International Journal of Gynecological Patholo. 15(1). 45-53 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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