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1996 Fiscal Year Final Research Report Summary

Obstructed Migration of Trigeminal Motoneurons and Trigeminal

Research Project

Project/Area Number 07838048
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section時限
Research Field 咀嚼
Research InstitutionTokyo Metropolitan Institute for Neuroscience

Principal Investigator

TERASHIMA Toshio  Tokyo Metro. Inst. Neurosci. Senior Researcher, 解剖発生学研究部門, 副参事研究員 (20101892)

Co-Investigator(Kenkyū-buntansha) KISHIMOTO Yasuko  Tokyo Metro. Inst. Neurosci. Research Associate, 解剖発生学研究部門, 主事研究員
IKEDA Yayoi  Tokyo Metro. Inst. Neurosci. Research Associate, 解剖発生学研究部門, 研究員
Project Period (FY) 1995 – 1996
Keywordsreeler mouse / trigeminal motor nucleus / trigeminal mesencephalic nucleu / reelin / gill arch / facial nucleus
Research Abstract

Reeler (gene symbol, rl) is an autosomal recessive mutation occurring in mice and characterized by the abnormal positioning of neurons in the central nervous system. In this mutant, however, the cytoarchitecture of the peripheral nervous system is normal, implying that the reeler genetic locus does not affect migration of neurons in the periperal system. Mesencephalic trigeminal nucleus (Me5) neurons are unique in that they are derived from the neural crest like other neurons in the peripheral nervous system, but enter secondarily the central nervous system. We labeled Me5 neurons by injecting horseradish peroxidase or Fast Blue into the temporal muscle of normal and reeler mice to determine whether the migration of these neurons is affected by the reeler genetic locus. Labeled Me5 neurons of the reeler mouse were more widely scattered in comparison with their normal counterparts, suggesting that the reeler genetic locus affects migration of neurons which originate in the neural crest and then migrate into the central nervous system.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Terashima,T.: "Uistribution ot mesencephalic trigeminai mucleus neurons in the reeler mouse" Anatomical Record. 244. 563-571 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikeda,Y.: "Corticospinal tract neurons are radially malpositioned in the sensory-motor cortex of the shakina rat Kawasaki" J.Comparative Neurology. (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Terashima, T.: "The course and collaterals of corticospinal fibers arising from the sensory-motor cortex of the reeler mouse" Devlop. Neurosci.17. 8-19 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Terashima, T.: "Anatomy, development and lesion-induced plasticity of rodent corticospinal tract." Neurosci. Res.22. 139-161 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Terashima, T.: "Distribution of mesencephalic trigeminal neurons of the reeler mutant mouse." Anat. Rec.244. 563-571 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikeda, Y., and Terashima, T.: "Corticospinal tract neurons are radially malpositioned in the sensory-motor cortex of the Shaking Rat Kawasaki." J.Comp. Neurol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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