1998 Fiscal Year Final Research Report Summary
Genetic Effects of Low Dose Radiations in Man and Animals
| Project/Area Number |
08041174
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Field Research |
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| Research Field |
環境影響評価(含放射線生物学)
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| Research Institution | Osaka University |
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Principal Investigator |
NOMURA Taisei Osaka University Faculty of Medicine, Professor, 医学部, 教授 (90089871)
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| Co-Investigator(Kenkyū-buntansha) |
KRUPNOVA Evelina V. Belarus Academy of Sciences, Institute of Genetics and Cytology, Senior Research, 遺伝学・細胞学研究所, 主任研究員
ELISSEEVA Kl ベラルーシ科学アカデミー, 遺伝学・細胞学研究所, 部長
HONGYO Tadashi Osaka University Faculty of Medicine, Assistant Professor, 医学部, 助手 (90271569)
NAKAJIMA Hiroo Osaka University Faculty of Medicine, Assistant Professor, 医学部, 助手 (20237275)
SUGIYAMA Haruo Osaka University Faculty of Medicine, Professor, 医学部, 教授 (70162906)
ELISSEEVA Klavdiya G. Belarus Academy of Sciences, Institute of Genetics and Cytology, Chief
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| Project Period (FY) |
1996 – 1998
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| Keywords | Low dose radiations / Chernobyl catastrophe / Genetic effects / Ecological effects / Wild animals and plants / Biological concentration / Leukemia / WTl gene |
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| Research Abstract |
1. Contamination of Radionuclides after Chernobyl Catastrophe : Radionuclides were measured and identified in the contaminated area (Gomel, Khoiniki, Bragin) and uncontaminated area (Minsk). Radionuclides, mostly ^<137>, are concentrated in the glasshopper < dragonfly <mole <mouse, although those in the soil are decreasing. High concentration was also observed in carp and frog.
2. Ecological and Transgenerational Effects : Chromosomal aberrations still remain in Drosophila, frog, and mouse as high as those just after the accident, although ten years have passed. It may be caused by highly concentrated radionuclides in these animals, rather than transgenerational (genetic) effects.
3. Experimental Studies : Significantly high incidence of somatic mutations (spot test) was ditected in Drosophila by feeding contaminated red berry.
4. Genetic Effects in Human : Lymphocytes in the peripheral blood were collected from liquidators and people living in the contaminated area, and expression level of WT1 tumor gene, a maker of leukemia, was quantitated. 16 of 28 liquidators with hematological abnormality showed significantly high expression of WT1 gene, indicating a higher risk of leumekia. Some of the liquidators without hematological change and control Belarusian in the uncontaminated area (Minsk) showed moderately high expression of WT1, but all of 49 Japanese and 26 Cocasians living in Osaka showed undectable level of WT1.
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