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1996 Fiscal Year Final Research Report Summary

Assessment of Chinese Medicines for Incurable Diseases -Japan-China Collaborative Clinical and Pharmacological Assessment

Research Project

Project/Area Number 08044288
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionShimane Medical University

Principal Investigator

OKUNISHI Hideki  Shimane Med.Univ., Dept.Pharmacol., Professor, 医学部, 教授 (70111888)

Co-Investigator(Kenkyū-buntansha) 沈 嘉  瀋陽薬科大学, 薬学部, 助教授
CHEN Jifan  Guangzhou University of Traditional Chinese Medicine, Dean, 中医学部, 学部長
KOBAYASHI Yuta  Shimane Med.Univ., Dept.Pharmacol, Associate Professor, 医学部, 助教授 (40162028)
TAKAORI Shuji  Shimane Med.Univ., President, 医学部, 学長 (10025538)
SHEN Jia  Shenyang Pharmaceutical. Univ., Dept.Natr.Med.Chem., Associate Professor
Project Period (FY) 1996
Keywordsrheumatoid / collagen-induced chronic arthritis / T-cell / B-cell / X-ray / Tong-Bi-Ling / dulcitol / immunosuppression
Research Abstract

Takaori, Kobayashi, and Okunishi visited Guangzhou University of Traditional Chinese Medicine in July 1996, where President Takaori presented a lecture "Well-controlled clinical evaluation of Chinese medicine." Thereafter, researchers of both sides exchanged their data and discussed to make up an effective study plan for assessment of Tong-Bi-Ling (TBL), a Chinese recipe invented by Prof.Chen for incurable diseases.
Dr.Shen, a collaborator assigned by Prof.Chen, has joined our laboratory from August 1996 to March 1997. She prepared chemically some fractions containing active principles of TBL,and identified dulcitol as one of the candidates. In collaboration with us, she quantified dulcitol in TBL by HPLC analysis, and examined the pharmacological effects of TBL and dulcitol on rheumatoid arthritis induced in mice by immunizing with heterologous collagen. TBL improved arthritis symptoms and joint destruction on X-ray graphs. TBL also suppressed the increments in serum anticollagen antib … More ody and in T-cell and B-cell areas in the spleen, suggesting an immunosuppressive action. Dulcitol (0.1g/kg body weight/day) showed similar effects as TBL on arthritis symptoms and X-ray findings. However, inhibitory effect of dulcitol on increase in anti-collagen antibody was not significant. FACS analyzes delineated that dulcitol improved abnormality in the ratio of CD4+ and CD8+ T-cell subsets in the spleen lymphocytes. Thus, dulcitol appears to represent some of beneficial effects of TBL on arthritis.
New controlled clinical trials using TBL have been carried out in China, and attained significant progress which deserved to have gained a governmental grant of China. Prof.Chen visited us March 1997 to present and discuss the clinical outcome from new TBL trials on rheumatoid arthritis and tetanic spondylitis. Integrating their clinical with our basic results, we have attained a goal of the 1996 joint program, and have pointed out several important issues which await further studies in the future project. Less

  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Li,S.-H.: "Suppressive effects of a herbal formula TBL-1 on type II collagen-induced arthritis in DBA/1J mice." Clinical & Experimental Pharmacology & Physiology. 20・2. 236-240 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takai,S.: "Purification and characterization of angiotensin II-generating chymase from hamster cheek pouch." Life Sciences. 58・7. 591-597 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsubara,K.: "Differences in dopamine efflux induced by MPP^+ and β-carbolinium in the striatum of conscious rats." Eur.J.Pharmacol.315. 145-151 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobayashi,Y.: "Immunosuppressive effects of a traditional chinese medicine TBL-1 on collagen-induced arthritis." Hong Kong Journal of Gerontology. 10. 311-314 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takai,S.: "Antinociceptive effects of angiotensin-coverting enzyme inhibitors and an angiotensin II receptor antagonist in mice." Life Sciences. 59・21. PL331-336 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奥西秀樹: "キマ-ゼの病態生理学的意義" 内分泌・糖尿病科. 3・6. 535-543 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奥西秀樹: "血管系におけるレニン・アンジオテンシン系" ホルモンと臨床. 44・12. 1289-1296 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsubara,K: "Modulation of tryptophan hydroxylase activity in vitro by ethanol depends on biopterin cofactor concentration." Alcohol. 13・5. 455-459 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kakizoe、E.: "Effect of N^G-monomethyl-L-arginine on the microcirculation of rat skin." Clinical & Experimental Pharmacology & Physiology. 24・2(印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shiota,N.: "Activation of angiotensinll-forming chymase in the hamster cardiomypathic heart." Journal of Hypertension. 15(印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawamoto,T.: "Site and mechanism of persistent antihypertensive action of lisinopril in the spontaneously hypertensive rat." Jpn.Pharmacol.Ther.25(印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林裕太: "新老年学[第二版](編集代表 折茂肇)(分担執筆 内分泌系の加齢変化)" 東京大学出版会(印刷中), (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Li, S.-H., Kobayashi, Y., Yamauchi, Y., Gonda, T.and Tsunematsu, T.: "Suppressive effects of a herbal formula TBL-1 on type II collagen-induced arthritis in DBA/1J mice." Clin.Exp.Pharmacol.Physiol.20-2. 236-240 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takai, S., Shiota, N., Yamamoto, D., Okunishi, H.and Miyazaki, M.: "Purification and characterization of angiotensin II-generating chymase from hamster cheek pouch." Life Sci.58-7. 591-597 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsubara, K., Idzu, T., Kobayashi, Y., Gonda, T., Okunishi, H.and Kimura, K.: "Differences in dopamine effluxinduced by MPP^+ and beta-carbolinium in the striatum of conscious rats." Eur.J.Pharmacol.315. 145-151 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi, Y., Li, S.-H., Gonda, T., Yamauchi, Y., Harada, T.and Okunishi, H.: "Immunosuppressive effects of a traditional Chinese medicine TBL-1 on collagen-induced arthritis." Hong Kong J.Gerontol.10, (Suppl.). 311-314 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takai, S.Song, K., Tanaka, T., Okunishi, H.and Miyazaki, M.: "Antinociceptive effects of angiotensin-coverting enzyme inhibitors and an angiotensin II receptor antagonist in mice." Life Sci.59-21. PL331-336 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okunishi, H.: "Pathopysiological role of cardiovascularchymase. (in Japanese)" Endocrinology & Diabetology. 3-6. 535-543 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okunishi, H.and Kakizoe, E.: "Vascular renin-angiotensin system. (in Japanese)" Clinical Endocrinology. 44-12. 1289-1296 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsubara, K., Kobayashi, Y., Tanabe, Y., Maruyama, W., Ishinaga, Y., Idzu, T., Kimura, K.and Naoi, M.: "Modulation of tryptophan hydroxylase activity in vitro by ethanol depends on biopterin cofactorconcentration." Alcohol. 13-5. 455-459 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kakizoe, E., Kobayashi, Y., Okunishi, H., Shimoura, K., Hattori, K.and Jidoi, J.: "Effect of N^G-monomethyl-L-arginine on the microcirculation of rat skin." Clin.Exp.Pharmacol. Physiol.24-2 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shiota, N., Fukamizu, A,Takai, S., Okunishi, H., Murakami, K.and Miyazaki, M.: "Activation of angiotensin II-formingchymase in the hamster cardiomypathic heart." J.Hypertens.15 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawamoto, T., Nakamura, M., Okunishi, H., Shiota, N.and Miyazaki, M.: "Site and mechanism of persistent antihypertensive action of lisinopril in the spontaneously hypertensive rat." Jpn.Pharmacol. Ther.25 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi, Y.: Age-related changes in endocrine system. In : (Ed.by H.Orimo) New Gerontology [2nd edition] (in Japanese). Tokyo Univ.Press (in press), (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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