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1999 Fiscal Year Final Research Report Summary

Exploration of Practical Synthetic Tolls for Molecular Construction

Research Project

Project/Area Number 08245102
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionThe Kitasato Institute (1998-1999)
Tokyo Institute of Technology (1996-1997)

Principal Investigator

KUWAJIMA Isao  The Kitasato Institute, Research Director, 生物機能研究所, 部長 (50016086)

Co-Investigator(Kenkyū-buntansha) SUZUKI Keisuke  Tokyo Institute of Technology, Graduate School of Science and Technology, Professor, 大学院・理工学研究科, 教授 (90162940)
NARASAKA Koichi  University of Tokyo, Graduate School of Science, Professor, 大学院・理学系研究科, 教授 (50016151)
ITO Yoshihiko  Kyoto University, Graduate School of Engineering, Professor, 大学院・工学研究科, 教授 (40026018)
Project Period (FY) 1996 – 1998
KeywordsComplex Structure / Natural Products / Useful Methodologies / Total Synthesis
Research Abstract

Purpose : Exploration of Useful Methodologies and Synthesis of Complex Natural Products
Members : 1996, 8 (for Appraisal) and 73 (for Research)
1997, 8 (for Appraisal) and 78 (for Research)
1998, 8 (for Appraisal) and 75 (for Research)
Meetings : 1st Symposium : January 13-14, 1997 (Kyoto)
2nd Symposium : June 12-13, 1997 (Tokyo)
3rd Symposium : December 8-9, 1997 (Osaka)
4th Symposium : May 21-22, 1998 (Sendai)
5th Symposium : December 14-15, 1998 (Tokyo)
6th Symposium : July 2, 1999 (Tokyo)
Publications : Research Abstracts of Every Member in 1996
Research Abstracts of Every Member in 1997
Research Abstracts of Every Member in 1998
Research Abstracts of Every Member in 1999
Total syntheses of a lot of celebrated natural products such as taxol, radicsicol, rabidomycin, polycavernoside A, madindoline, zaragozic acid A, antillatoxin, fredericamycin, terpestacin, streptovaricin U and so on, have been achieved. For construction of organic molecule, several useful methodologies have been developed for selective construction of heterocycles containing nitrogen, cyclic poly ether structures, acyclic polyols, and asymmetric construction quaternary carbon useful for the syntheses of complex natural products

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 桑嶋功: "Enantioselective Total Synthesis of Taxol"J.Am. Chem. Soc.. 120. 12980-12981 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 桑嶋功: "Total Synthesis of (-)-Coriolin"J.Org. Chem. 64. 2648-2656 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 桑嶋功: "Enantioselective Total Synthesis of (+)-Taxusin"J.Am. Chem. Soc.. 121. 3072-3082 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 伊藤嘉彦: "Stereoselective 1,4-Silaboration of 1,3-Dienes Catalyzed by Nickel Complexes"Org. Lett. 1. 1567-1569 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奈良坂紘一: "Photochemical Generation of Radical Species from α-Stannyl Ethers and Their Reaction with Conjugate Enones"Chem. Lett. 425-426 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木啓介: "Total Synthesis of Pradimicinone, the Common Aglycon of the Pradimicin-Benanomicin Antibiotics"Angew. Chem. Int.Ed., Engl.. 38. 1229-1232 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] I. Kuwajima: "Enantioselective Total Synthesis of Taxol"J. Am. Chem. Soc.. 120, No.49. 12980-12981 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I. Kuwajima: "Total Synthesis of (-)-Coriolin"J. Org. Chem.. 64, No.8. 2648-2656 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I. Kuwajima: "Enantioselective Total Synthesis of (+)-Taxusin"J. Am. Chem. Soc.. 121, No.13. 3072-3082 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Ito: "Stereoselective 1,4-Silaboration of 1,3-Dienes Catalyzed by Nickel Complexes.-"Org. Lett.. 1, No.10. 1567-1569 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Narasaka: "Photochemical Generation of Radical Species from α-Stannyl Ethers and Their Reaction with Conjugate Enones"Chem. Lett.. No.5. 425-426 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Suzuki: "Total Synthesis of Pradimicinone, the Common Aglycon of the Pradimicin-Benanomicin Antibiotics"Angew. Chem. Int. Ed. Engl.. 38, No.6. 1229-1232 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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