1996 Fiscal Year Annual Research Report

二次元高分子組織体

Research Project

Project/Area Number	08246106
Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Research Institution	Kyushu University
Principal Investigator	国武豊喜九州大学, 工学部, 教授 (40037734)
Co-Investigator(Kenkyū-buntansha)	中嶋直敏長崎大学, 工学部, 教授 (80136530) 原田明大阪大学, 大学院・理学研究科, 助教授 (80127282) 宍戸昌彦岡山大学, 工学部, 教授 (60026268) 岡田鉦彦名古屋大学, 農学部, 教授 (20023103)
Keywords	高分子積層体 / 球状・ナノ組織体 / デンドリマ- / 超蛋白質 / ポリロタキサン / シクロデキストリン / フラーレン超薄膜
Research Abstract	(1)交互吸着法による二次元高分子組織体作製の新しい展開としてポリイオンと無機イオン構造体を組み合わせた。また、吸着ポリマー層の化学修飾を利用して、二次元ネットワークなどの新しい組織体を作り出した。(国武) (2)新構造高分子として、ツインデンドリマ-型高分子の骨格である球状/線状ブロック型高分子および球状糖鎖高分子シュガ-ボールの合成を行い、これらが重水中でそれぞれ直径54nmおよび80nmの球状ナノ組織体を自発的に形成することを中性子小角散乱法で明らかにした。球状分子表面近傍ナノメートル領域で化学反応の高速化が起こるという新現象を見出した。(岡田) (3)側鎖にアンスラキノニル基やフェロセニル基をもつ光学活性非天然アミノ酸を合成し、これらのポリペプチドは電極からの電子をヘリックスに沿って伝達する電子伝達体として働くことを明らかにした。(宍戸) (4)シクロデキストリン(CD)から得られるポリロタキサン中の隣り合うCD同志を結合し、ポリマー鎖を取り除くことによってチューブ状のポリマーを得た。このポリマーの水酸基をアセチル化することにより、疎水性のチューブを得た。このチューブは種々の有機溶媒に可溶であり、種々のアルカリ金属塩など有機溶媒に溶けない金属塩を有機溶媒中に溶かし込むことことがわかった。(原田) (5)発色団を含むポリエチレングリコール(PEG)脂質を合成し、これから形成された二分子膜とα-CDとの包接錯体、並びに包接錯体をベースとしたポリロタキサンの合成に成功した。包接錯体が二分子膜特性を保持していること、またポリロタキサンが二分子膜構造を形成していることがわかった。また、フラーレン脂質を設計・合成し、これが二次元界面で単分子膜を形成することを見出した。(中嶋)

Research Products
(32 results)

All Other

All Publications (32 results)

[Publications] M.Sano,: "Formation of Ultrathin Polymer Layers on Solid Substrates by Means of Polvmerization-Induced Epitaxy and AlternateAdsorption" Annu.Rev.Mater.Sci.,. 26. 153-187 (1996)
[Publications] I.Ichinose: "Layer-by-Layer Assembly of Aqueous Bilayer Membranes on Charged Surfaces" Chemistry Letters. 1996・4. 257-258 (1996)
[Publications] N.Kimizuka: "Organic Two-Dimensional Templates for the Fabrication of Inorganic Nanostructures:Organic/Inorganic Superlattice" Adv.Mater.8・1. 89-91 (1996)
[Publications] I.Ichinose: "Stepwise Adsorption of Metal Alkoxides on Hydrolyzed Surfaces:A Surface Sol-Gel Process" Chemistry Letters. 1996・10. 831-832 (1996)
[Publications] T.Kunitake: "Molecular recognition at the air-water interface and two-dimensional molecular organization" Supramolewlar Science. 3・1-3. 45-51 (1996)
[Publications] K.Aoi: "First Synthesis of Glycopeptide Macromonomers and Graft-Type Sugar-Containing Polymers with Glycopeptide Side Chains" Macromolecules. 29・12. 4456-4458 (1996)
[Publications] K.Aoi: "Polymerization of Oxazolines" Progress in Polymer Science. 21・1. 151-208 (1997)
[Publications] K.Naka: "Aggregate of Peptide-Containing Block Copolymer with Lipase" Macromolecular Rapid Communication. 17・4. 269-274 (1996)
[Publications] 岡田鉦彦: "球状糖鎖高分子シュガ-ボールの合成と応用" バイオインダストリー. 13・8. 42-50 (1996)
[Publications] 岡田鉦彦: "球状糖鎖高分子シュガ-ボール" 化学と工業. 49・9. 1259-1261 (1996)
[Publications] M.Sisido: "Photoinduced Elecron Transfers on α-Helical Polypeptides" Peptide Chemistry. 1995. 513-516 (1996)
[Publications] M.Kuragaki: "Long-Distance Singlet Energy Transfer along α-Helical Polypeptide Chains" Journal of Physical Chemistry. 100・39. 16019-16025 (1996)
[Publications] T.Hohsaka: "Incorporation of Nonnatural Amino Acids into Streptavidin through In Vitro Frame-Shift Suppression" Journal of American Chemical Society. 118・40. 9778-9779 (1996)
[Publications] M.Kuragaki: "Highly Efficient Energy Transfer from Tryptophans in Avidin Tetramer to Biotin-Linked Pyrenylalanine" Bulletin of Chemical Society,Japan. 70・1. 261-265 (1997)
[Publications] M.Kira: "Synthesis and Redox Property of Polypeptides Containing L-Ferrocenylalanine" Chemistry Letters. 1997・1. 89-90 (1997)
[Publications] A.Harada: "Preparation and Characterization of Inclusion Complexes of Polyisobutylene with Cyclodextrins" Macromolecules. 29・17. 5611-5614 (1996)
[Publications] A.Harada: "Complex Formation of Cyclodextrins with Cationic Polymers" Polym.J. 28・2. 159-163 (1996)
[Publications] A.Harada: "Supramolecular Architectures Consisting of Polymers and Cyclodextrins" Coord.Chem.Rev.148・1. 115-133 (1996)
[Publications] A.Harada: "Supramolecular Assemblies through Macromolecular Recognition by Cyclodextrins" Supramolecular Science. 3・1-3. 19-23 (1996)
[Publications] A.Hashizume: "Polymerization of an azastyrene derivative,1,1,6-Addition Polymerization of 2,6-diisopropyl-N-methyleneaniline" Macromol.Rapid Commun.17. 529-537 (1996)
[Publications] H.Murakami: "Fullerene Lipid Chemistry:Self-Organized Multibilayer Films of a C60-Bearing Lipid with Main and Subphase Transitions," J.Am.Chem.Soc.118. 4484-4485 (1996)
[Publications] N.Nakashima: "Electrochemical Characterization of an Assembled Monolayer of α-Methoxy-ω-mercaptopoly(ethylene glycol)on Gold and Complex Formation of the Monolayer with α-Cyclodextrin" Chem.Lett.1996. 731-732 (1996)
[Publications] A.-E.F.Nassar: "Electrochemistry of Cast films of Ferredoxin and Lipid Bilayers on Electrodes" J.Electroanal.Chem.416. 183-185 (1996)
[Publications] M.Tominaga: "Tuning of lipid bilayer fluidity regulates mediated electron transter reactions of glucose oxidase immobilized on lipid bilayer films on an electrode" Bioelectrochem.Bioenerg.(in press).
[Publications] M.Okada: "Glycoproteins(Synthesis by NCA Method)in"The Polymeric・Materials Encyclopedia"" J.C.Salamone,ed., CRC Press,Inc.,Boca Raton,FL.U.S.A, 9218 (1996)
[Publications] M.Okada: "Bicyclic Acetals,Ring-Opening Polymerization in"The Polymeric Materials Encyclopedia"" J.C.Salamone,ed., CRC Press,Inc.,Boca Raton,FL.U.S.A, 9218 (1996)
[Publications] 宍戸昌彦: "籏野昌弘監修「新タンパク質応用工学」" フジテクノシステム, 950 (1996)
[Publications] M.Sisido: "M.Rosoff,ed.,"Vesicles"" Marcel Dekker,Inc, 752 (1996)
[Publications] A.Harada: "New Macromolecular Architectures and Functions" Springer-Verlag,Berlin, 207 (1996)
[Publications] A.Harada: "Comprehensive Supramolecular Science" Pergamon, 693 (1996)
[Publications] 中嶋直敏: "タンパク質応用工学" フジテクノシステム社, 951 (1996)
[Publications] 冨永昌人: "蛋白質・核酸・酵素" 共立出版, 92 (1996)

1996 Fiscal Year Annual Research Report

二次元高分子組織体

Principal Investigator

国武 豊喜 九州大学, 工学部, 教授 (40037734)

Research Products

[Publications] M.Sano,: "Formation of Ultrathin Polymer Layers on Solid Substrates by Means of Polvmerization-Induced Epitaxy and AlternateAdsorption" Annu.Rev.Mater.Sci.,. 26. 153-187 (1996)

[Publications] I.Ichinose: "Layer-by-Layer Assembly of Aqueous Bilayer Membranes on Charged Surfaces" Chemistry Letters. 1996・4. 257-258 (1996)

[Publications] N.Kimizuka: "Organic Two-Dimensional Templates for the Fabrication of Inorganic Nanostructures:Organic/Inorganic Superlattice" Adv.Mater.8・1. 89-91 (1996)

[Publications] I.Ichinose: "Stepwise Adsorption of Metal Alkoxides on Hydrolyzed Surfaces:A Surface Sol-Gel Process" Chemistry Letters. 1996・10. 831-832 (1996)

[Publications] T.Kunitake: "Molecular recognition at the air-water interface and two-dimensional molecular organization" Supramolewlar Science. 3・1-3. 45-51 (1996)

[Publications] K.Aoi: "First Synthesis of Glycopeptide Macromonomers and Graft-Type Sugar-Containing Polymers with Glycopeptide Side Chains" Macromolecules. 29・12. 4456-4458 (1996)

[Publications] K.Aoi: "Polymerization of Oxazolines" Progress in Polymer Science. 21・1. 151-208 (1997)

[Publications] K.Naka: "Aggregate of Peptide-Containing Block Copolymer with Lipase" Macromolecular Rapid Communication. 17・4. 269-274 (1996)

[Publications] 岡田鉦彦: "球状糖鎖高分子シュガ-ボールの合成と応用" バイオインダストリー. 13・8. 42-50 (1996)

[Publications] 岡田鉦彦: "球状糖鎖高分子シュガ-ボール" 化学と工業. 49・9. 1259-1261 (1996)

[Publications] M.Sisido: "Photoinduced Elecron Transfers on α-Helical Polypeptides" Peptide Chemistry. 1995. 513-516 (1996)

[Publications] M.Kuragaki: "Long-Distance Singlet Energy Transfer along α-Helical Polypeptide Chains" Journal of Physical Chemistry. 100・39. 16019-16025 (1996)

[Publications] T.Hohsaka: "Incorporation of Nonnatural Amino Acids into Streptavidin through In Vitro Frame-Shift Suppression" Journal of American Chemical Society. 118・40. 9778-9779 (1996)

[Publications] M.Kuragaki: "Highly Efficient Energy Transfer from Tryptophans in Avidin Tetramer to Biotin-Linked Pyrenylalanine" Bulletin of Chemical Society,Japan. 70・1. 261-265 (1997)

[Publications] M.Kira: "Synthesis and Redox Property of Polypeptides Containing L-Ferrocenylalanine" Chemistry Letters. 1997・1. 89-90 (1997)

[Publications] A.Harada: "Preparation and Characterization of Inclusion Complexes of Polyisobutylene with Cyclodextrins" Macromolecules. 29・17. 5611-5614 (1996)

[Publications] A.Harada: "Complex Formation of Cyclodextrins with Cationic Polymers" Polym.J. 28・2. 159-163 (1996)

[Publications] A.Harada: "Supramolecular Architectures Consisting of Polymers and Cyclodextrins" Coord.Chem.Rev.148・1. 115-133 (1996)

[Publications] A.Harada: "Supramolecular Assemblies through Macromolecular Recognition by Cyclodextrins" Supramolecular Science. 3・1-3. 19-23 (1996)

[Publications] A.Hashizume: "Polymerization of an azastyrene derivative,1,1,6-Addition Polymerization of 2,6-diisopropyl-N-methyleneaniline" Macromol.Rapid Commun.17. 529-537 (1996)

[Publications] H.Murakami: "Fullerene Lipid Chemistry:Self-Organized Multibilayer Films of a C60-Bearing Lipid with Main and Subphase Transitions," J.Am.Chem.Soc.118. 4484-4485 (1996)

[Publications] N.Nakashima: "Electrochemical Characterization of an Assembled Monolayer of α-Methoxy-ω-mercaptopoly(ethylene glycol)on Gold and Complex Formation of the Monolayer with α-Cyclodextrin" Chem.Lett.1996. 731-732 (1996)

[Publications] A.-E.F.Nassar: "Electrochemistry of Cast films of Ferredoxin and Lipid Bilayers on Electrodes" J.Electroanal.Chem.416. 183-185 (1996)

[Publications] M.Tominaga: "Tuning of lipid bilayer fluidity regulates mediated electron transter reactions of glucose oxidase immobilized on lipid bilayer films on an electrode" Bioelectrochem.Bioenerg.(in press).

[Publications] M.Okada: "Glycoproteins(Synthesis by NCA Method)in"The Polymeric・Materials Encyclopedia"" J.C.Salamone,ed., CRC Press,Inc.,Boca Raton,FL.U.S.A, 9218 (1996)

[Publications] M.Okada: "Bicyclic Acetals,Ring-Opening Polymerization in"The Polymeric Materials Encyclopedia"" J.C.Salamone,ed., CRC Press,Inc.,Boca Raton,FL.U.S.A, 9218 (1996)

[Publications] 宍戸昌彦: "籏野昌弘監修「新タンパク質応用工学」" フジテクノシステム, 950 (1996)

[Publications] M.Sisido: "M.Rosoff,ed.,"Vesicles"" Marcel Dekker,Inc, 752 (1996)

[Publications] A.Harada: "New Macromolecular Architectures and Functions" Springer-Verlag,Berlin, 207 (1996)

[Publications] A.Harada: "Comprehensive Supramolecular Science" Pergamon, 693 (1996)

[Publications] 中嶋直敏: "タンパク質応用工学" フジテクノシステム社, 951 (1996)

[Publications] 冨永昌人: "蛋白質・核酸・酵素" 共立出版, 92 (1996)

国武豊喜九州大学, 工学部, 教授 (40037734)