1996 Fiscal Year Annual Research Report

成人型早老症Werner症候群における発がんの研究

Research Project

Project/Area Number	08264239
Research Institution	Japanese Foundation For Cancer Research
Principal Investigator	石川雄一財団法人癌研究會, 癌研究所病理部, 主任研究員 (80222975)
Co-Investigator(Kenkyū-buntansha)	後藤真東京都立大塚病院, リウマチ・膠原病科, 医長西田一典財団法人癌研究會, 癌研究所病理部, 研究員 (60280624)
Keywords	Werner症候群 / 骨肉腫 / 甲状腺癌
Research Abstract	成人型早老症Werner症候群に発生した腫瘍,特に骨肉腫および甲状腺癌の性質を調べた. 1.Werner症候群に発生した骨肉腫8例には以下の特徴が見られた.(1)Werner症候群の骨肉腫では,対照と異なり女性優位であった.(2)年齢が平均46歳と高く,一般の骨肉腫(平均24歳)と好対照であった.(3)発生部位が典型的でないものが多かった.(4)組織亜型がosteoblastic type以外が半数を占めた. 2.新鮮腫瘍組織を入手できた1例についてp53遺伝子の突然変異を検討した結果,変異を認めなかった.またこの患者のWRN遺伝子におけるgermline mutationを検討した結果,わが国,外国共にまだ報告のない新しいmutationであった. 3.Werner症候群に発生した甲状腺癌24例を臨床病理学的に検討して一般例と比較した.その結果,(1)平均年齢は39歳で,対照群より10歳若い,(2)対照群より女性が少ない,(3)組織型では,濾胞癌がはるかに多い,(4)未分化癌が増加という特徴が見られた. 4.Werner症候群に発生した骨肉腫と甲状腺癌は,一般のものとやや異なっており,発癌メカニズムの違いを示唆していた.

Research Products
(6 results)

All Other

All Publications (6 results)

[Publications] Satoh Y,Ishikawa Yら: "A follow-up study of progression from dysplasia to squamous cell carcinoma with immuno-histochemical examination of p53 protein over-expression in the bronchi of ex-chromate workers." BrJ Cancer. 75. 678-83 (1997)
[Publications] Goto M,Imamura Oら: "Analysis of helicase gene mutations in Japanese Werner's syndrome patients." Hum Genet. 99. 191-3 (1997)
[Publications] Matsumoto T,Imamura O,ら: "Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure : Genetic epidemiology in the Japanese population." Hum Genet (in press). (1997)
[Publications] Goto M,Miller RW,Ishikawa Yら: "Excess of rare cancers in Werner syndrome (adult progeria)" Cancer Epidemiol.Biomark.Prev.5. 239-246 (1996)
[Publications] Ishikawa Y,ら: "Low rates of Paget disease of bone and osteosarcoma in elderly Japanese." Lancet. 347. 1559- (1996)
[Publications] Yoshimura K.Fukui I,Ishikawa Y,ら: "Locally-confined signet-ring cell carcinoma of the prostate : a case report of a long-term survivor." IntJ Urol. 3. 406-7 (1996)

1996 Fiscal Year Annual Research Report

成人型早老症Werner症候群における発がんの研究

Principal Investigator

石川 雄一 財団法人癌研究會, 癌研究所病理部, 主任研究員 (80222975)

Research Products

[Publications] Satoh Y,Ishikawa Yら: "A follow-up study of progression from dysplasia to squamous cell carcinoma with immuno-histochemical examination of p53 protein over-expression in the bronchi of ex-chromate workers." BrJ Cancer. 75. 678-83 (1997)

[Publications] Goto M,Imamura Oら: "Analysis of helicase gene mutations in Japanese Werner's syndrome patients." Hum Genet. 99. 191-3 (1997)

[Publications] Matsumoto T,Imamura O,ら: "Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure : Genetic epidemiology in the Japanese population." Hum Genet (in press). (1997)

[Publications] Goto M,Miller RW,Ishikawa Yら: "Excess of rare cancers in Werner syndrome (adult progeria)" Cancer Epidemiol.Biomark.Prev.5. 239-246 (1996)

[Publications] Ishikawa Y,ら: "Low rates of Paget disease of bone and osteosarcoma in elderly Japanese." Lancet. 347. 1559- (1996)

[Publications] Yoshimura K.Fukui I,Ishikawa Y,ら: "Locally-confined signet-ring cell carcinoma of the prostate : a case report of a long-term survivor." IntJ Urol. 3. 406-7 (1996)

石川雄一財団法人癌研究會, 癌研究所病理部, 主任研究員 (80222975)