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2000 Fiscal Year Final Research Report Summary

Formation and storage of memory

Research Project

Project/Area Number 08279103
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionThe University of Tokyo

Principal Investigator

AIHARA Kazuyuki  The University of Tokyo Graduate School of frontier Sciences, Professor, 大学院・新領域創世科学研究科, 教授 (40167218)

Co-Investigator(Kenkyū-buntansha) YAMADORI Atsushi  Tohoku University Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (10030892)
TSUKADA Minoru  Tanagawa University Department of Information Communication Engineering, Professor, 工学部, 教授 (80074392)
SAKATA Hideo  Nihon University School of Medicine Department of Physiology, Professor, 医学部, 教授 (10073066)
SHINOMOTO Shigeru  Kyoto University Department of Physics Graduate School of Science, Associate Professor, 大学院・理学研究科, 助教授 (60187383)
FUJII Hiroshi  Kyoto Sangyo University Department of Information & Communication Sciences, Professor, 工学部, 教授 (90065839)
Project Period (FY) 1996 – 1999
KeywordsHigh spatial resolution MEG / Short-term memory of 3D shape / Spatio temporal learning rule / Episodic memory / Hippocampus / Coincidence detector system / Dynamical cell assembly hypothesis / Spike statistics
Research Abstract

Toyama : Simultaneous study of psychophysical and cortical responses recorded by high spatial resolution MEG revealed responses localized in V2/3 that paralleled with perception of contours in various stimulus conditions, and indicated that V2/3 is the primary site for perception of contour from motion.
Sakata : l. We found in the anterior intraparietal (AIP) area, visually responsive neurons that discriminated 3D shape of object. Some of them showed sustained discharge during delay period, suggesting to represent immediate memory of 3D shape. 2. We found the surface-orientation-se1ective (SOS) neurons that responded
to the surface in the random-dot-stereogram suggesting to compute surface orientation from disparity gradient. 3. Axis orientation selective (AOS) neurons were sensitive to the orientation disparity and/or width disparity. 4. Relative position of the target of manipulation in the objects were also coded in AIP area.
Tsukada : We showed that the spatial distribution and amplit … More ude of LTP is highly sensitive to the statistical correlation between successive inter-stimulus intervals. We proposed a spatio-temporal learning rule based on the experimental plastncity induced by various spatio-temporal pattern stimuli in hippocampal CA1 area. The spatio-temporal learning rule can modify the weight space in the network in the most effective way to discriminate different spatio-temporal patterns.
Yamadori : We found neural basis for the maintenance of episodic memory and prospective memory using PET scan. Our clinical data stuggested the specific area for the retrieval of people's name or animate objects.
Iijima : The entorhinal-hippocampal interactions were studied in cellular and circuit level with the optical recording methods with voltage-sensitive dyes. Exsistence of the reverberation circuit in the entorhinal cortex and its meaning was craimed. Further, the regulation on the information propagation in the system by amygdala inputs was suggested.
Aihara : We found the following properties peculiar to neural networks composed of coincidence detector neurons : control of network functions by temporal input, ergodic encoding with spatio-temporal spikes and coincidence detection as a stochastic resonance phenomena with Poisson spike packets.
Fujii : We have proposed the Dynamical Cell Assembly Hypothesis as the basic coding mechanism of the cerebral cortex, based on the coincidence detector nature of the pyramidal neurons. Based on the above hypothesis, the binding mechanism of fragmentary information represented in distant brain areas was also investigated. Shinomoto : We found that the standard neuro-spiking models are not able to account for the spiking data recorded from monkey prefrontal cortex. We also attempted to revise the neuro-spiking model so as to make it consistent with the biological data. Less

  • Research Products

    (66 results)

All Other

All Publications (66 results)

  • [Publications] Adachi,M. and Aihara,K.: "Associative dynamics in a chaotic neural network "Neural Networks. 10(1). 83-98 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chen,L. and Aihara,K.: "Chaos and asymptotical stability in discrete-time neural networks"Physica D. 104. 286-325 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe,M., Aihara,K., et al: "A dynamical neural network with temproal coding and functional connectivity"Biol.Cybern.. 78. 87-93 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aihara,K., et al.: "Deterministic nonlinear dynamics of a forced oscillation experimentally observed with a squid giant axon"International Journal of Chaos Theory and Applications. 3(3). 5-20 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toyama,K., et al: "A new method for magnetoencephalography (MEG) : Three dimensional magnetometer-spatial filter system"Neuroscience. 91. 405-415 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y., Takanashi,Y., Ejima,Y. and Yoshizawa,S.: "A new method for magnetoencephalography (MEG) : Three dimensional magnetometer-spatial filter system"Neuroscience. 392. 494-497 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Higashi,S., Toyama,K., et al: "Altered spatial patterns of functional thalamocortical connections in barrel cortex after neonatal infraorbital nerve cut revealed by optical recording"Neuroscience. 439-452 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murata,A, Sakata,H., et al: "Parietal neurons related to memory-guided hand manipulation"J.Neurophysiol.. 75. 2180-2186 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakata,H., et al.: "The parietal association cortex in depth perception and visual control of hand action"Trends.in Neurosci. 20. 350-357 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taira,M., Sakata,H., et al.: "Parietal neurons represent surface orientation from the gradient of binocular disparity"J.Neurophsiol.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aihara,T., Tsukada,M., et al.: "Two dynamic processes for the induction of LTP in hippocampal CA1 neurons"Biological Cybernetics. 9. 189-195 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuda,H., Tsukada,M., Aihara,K., et al.: "Chaotic stimulus dependent on Long term potentiation (LTP) in the hippocampal CA1 area."The Brain & Neural Networks. 6. 117-127 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto,J., Tsukada,M., et al.: "An evoked dynamic interaction in the guinea pig auditory cortex by compound acoustic hippocampal stimuli-An optical imaging analysis"The Brain & Neural Networks. 6. 11-16 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujii,T., Yamadori,A., et al.: "Disproportionate retrograde amnesia in a patient with herpes simplex encephalitis"Cortex. 35. 599-614 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okuda,J., Yamadori,A., et al.: "Retention of words in long-term memory : a functional neuroanatomical study with PET."NeuroReport. 11. 323-328 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukatsu,R., Yamadori,A., et al.: "Proper name anomia after left temporal lobectomy : A patient study"Neurology. 52. 1096-1099 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iijima,T., et al.: "Entorhinal-hippocampal interactions revealed by real-time imaging"Science. 272. 1069-1232 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kondo,T., Iijima,T., et l.: "Differential alteration of hippocampal synaptic strength induced by pituitary adenylate cyclase activation polypeptide-38(PACAP-38)."Neuroscience Letters. 221. 189-192 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iijima,T., et al.: "Real-time optical imaging proides "dynamic map of brain activity" The fifth international conference on neural information processing."ICONIP'98. 329-332 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Marco de Curtis,Iijima,T., et al.: "Optical recording of cortical activity after in vitro perfusion of cerebral arteries with a voltage-sensitive dye"Brain Research. 837. 314-319 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Otsu,Y., Iijima,T., et al.: "Spatio-temporal pattern of Granule cell activities in the hippocampal dentate gyrus of kinate-treated rats : an optical recording study"J.Neurophysiol.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujii,H., Aihara,K., Tsukada,M., et al.: "Dynamical cell assembly hypothesis-theoretical possibility of spatio-temporal coding in the cortex"Neural Networks. 9. 1303-1350 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤井 宏: "脳の符号化機構への新しいシナリオ-動的細胞集成体仮説"科学. 66(12). 880-888 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aihara,T., Tsukada,M., Shinomoto,S, et al.: "Stimulus-dependent induction of long-term-potentiation in CA1 area of the hippocampus experiment and model."Hippocampus. 7. 416-426 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinomoto,S., et al.: "The Ornstein-Uhlenbeck process does not reproduce spiking statistics of neurons in prefrontal cortex"Neural Computation. 11. 935-951 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakai,Y., Shinomoto,S., et al.: "Temporally correlated inputs to leaky integrate-and-fire models can reproduce spiking statistics of cortical neurons"Neural Networks. 12. 1181-1190 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 合原一幸: "脳とカオス"クバプロ. 10 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 合原一幸: "複雑系がひらく世界・科学・技術・社会へのインパクト別冊日経サイエンス120"日経サイエンス社. 182 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toyama,K., et al.: "A new technique in magnetoencephalography and its application to visual neuroscience"Smith-Gordon Publisher(in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakata,H., et al.: "Role of the parietal cortex in perception and memory of three-dimensional features of objects"Elsevier. 18 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakata,H., et al.: "Role of the parietal association cortex in depth perception and hand action"Harwood Academic Publishers. 28 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakata,H., et al.: "Parietal visual neurons coding three-dimensional characteristics of objects and their relation to hand action"Springer. 18 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤井俊勝,山鳥重 他: "記憶の障害"中山書店. 12 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤井俊勝,山鳥 重: "記憶の神経心理学"メディカルレビュー社. 12 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 月浦 崇, 山鳥 重: "側頭葉健忘"中山書店. 205-220 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinomoto,S. and Sakai,Y.: "Inter-spike interval statistics of cortical neurons"Springer. 365 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Adachi, M.and Aihara, K.: "Associative dynamics in a chaotic neural network"Neural Networks. 10(1). 83-98 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chen, L.and Aihara, K.: "Chaos and asymptotical stability in discrete-time neural networks."Physica D. 104. 286-325 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe, M., Aihara, K., et at.: "A dynamical neural network with temproal coding and functional connectivity"Biol.Cybern.. 78. 87-93 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aihara, K., et al.: "Deterministic nonlinear dynamics of a forced oscillation experimentally observed with a squid giant axon."Internation Journal of Chaos Theory and Applications. 3(3). 5-20 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toyama, K., et al.: "Y., Takanashi, Y., Ejima, Y.and Yoshizawa, S.A new method for magnetoencephalography (MEG) : Three dimensional magnetometer-spatial filter system"Neuroscience. 91. 405-415 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Higashi, S., Toyama, K., et al.: "Altered spatial patterns of functional thalamocortical connections in barrel cortex after neonatal infraorbital nerve cut revealed by optical recording"Neuroscience. 91. 439-452 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, A, Sakata, H., et al.: "Parietal neurons related to memory-guided hand manipulatio"Nature. 403. 192-195 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakata, H., et al.: "The parietal association cortex in depth perception and visual control of hand action"Trends.in Neurosci.. 20. 350-357 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakata, H., et al.: "Neural coding of 3D features of objects for hand action in the parietal cortex of the monkey"Phil.Trans.R.Soc.Lord.B. 353. 1363-1373 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Taira, M., Sakata, H., et al.: "Parietal neurons represent surface orientation from the gradient of binocular disparity."Neurophsiol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aihara, T., Tsukada, M., et al.: "Two dynamic processes for the induction of LTP in hippocampal CA1 neurons."Biological Cybernetics. 9(82). 189-195 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuda, H., Tsukada, M., Aihara, K., et al.: "Chaotic stimulus dependent on Long term potentiation (LTP) in the hippocampal CA1 area."The Brain & Neural Networks. 6(2). 117-127 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto, J., Tsukada, M., et al.: "An evoked dynamic interaction in the guinea pig auditory cortex by compound acoustic-hippocampal stimuli-An optical imaging analysis"The Brain & Neural Networks. 6(1). 11-16 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujii, T,, Yamadori, A., et al.: "Disproportionate retrograde amnesia in a patient with herpes simplex encephalitis."Cortex. 35. 599-614 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okuda, J., Yamadori, A., et al.: "Retention of words in long-term memory : a functional neuroanatomical study with PET."Neuro Report. 11. 323-328 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukatsu, R., Yamadori, A., et al.: "Proper name anomia after left temporal lobectomy : A patient study."Neurology. 52. 1096-1099 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iijima, T., et al.: "Entorhinal-hippocampal interactions revealed by real-time imaging."Science. 272. 1069-1232 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kondo, T., lijima, T., et al.: "Differential alteration of hippocampal synaptic strength induced by pituitary adenylate cyclase activation polypeptide-38 (PACAP-38)."Neuroscience Letters. 221. 189-192 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iijima, , et al.: "Real-time optical imaging provides "dynamic map of brain activity" The fifth international conference on neural information processing."ICONIP'98. 329-332 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Marco de Curtis, Iijima, T., et al.: "Optical recording of cortical activity after in vitro perfusion of cerebral arteries with a voltage-sensitive dye"Brain Research. 837. 314-319 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Otsu, Y., Iijima, T., et al.: "Spatio-temporal pattern of Granule cell activities in the hippocampal dentate gyrus of kinate-treated rats : an optical recording study"J.Neurophysiol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujii, H., Aihara, K., Tsukada, M., et al.: "Dynamical cell assembly hypothesis-theoretical possibility of spatio-temporal coding in the cortex"Neural Networks. 9. 1303-1350 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aihara, T., Tsukada, M., Shinomoto, S, et al.: "Stimulus-dependent induction of long-term-potentiation in CA1 area of the hippocampus experiment and model."Hippocampus. 7. 416-426 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinomoto, S., et al.: "The Ornstein-Uhlenbeck process does not reproduce spiking statistics of neurons in prefrontal cortex"Neural Computation. 11. 935-951 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakai, Y., Shinomoto, S., et al.: "Temporally correlated inputs to leaky integrate-and-fire models can reproduce spiking statistics of cortical neurons"Neural Networks. 12. 1181-1190 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toyama, K., et al.: "A new technique in magnetoencephalography and its application to visual neuroscience"Smith-Gordon Publisher (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakata, H., et al.: "Role of the parietal cortex in perception and memory of three-dimensional features of objects"Elsevier. 377-395 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakata, H., et al.: "Role of the parietal association cortex in depth perception and hand action"Harwood Academic Publishers. 137-161 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakata, H., et al.: "Parietal visual neurons coding three-dimensional characteristics of objects and their relation to hand action"Springer. 237-254 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinomoto, S.and Sakai, Y.: "Inter-spike interval statistics of cortical neurons"Springer. 865 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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