1996 Fiscal Year Annual Research Report

情動と思考のメカニズム

Research Project

Project/Area Number	08279105
Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Research Institution	Toyama Medical and Pharmaceutical University
Principal Investigator	小野武年富山医科薬科大学, 医学部, 教授 (50019577)
Co-Investigator(Kenkyū-buntansha)	澤口俊之北海道大学, 心理, 助教授 (00183830) 森田昌彦筑波大学, 電子・情報工, 講師 (00222349) 倉田耕治大阪大学, 基礎工, 講師 (40170071) 岩田誠東京女子医科大学, 脳神経センター, 教授 (90107665) 安西祐一郎慶応義塾大学, 理工, 教授 (40051875)
Keywords	情動 / 思考 / 大脳辺縁系 / 前頭葉 / 相貌失認 / 選好 / 非単調神経回路 / 自己組織化
Research Abstract	本研究では,情動と思考のメカニズムを解明するため,脳内の注意,認知,記憶,学習,運動系の核機能システムが,如何にダイナミックにコヒーレントになり,思考・情動の"流れ"が脳内に形成されるのか,その作動原理を明らかにするための基礎的研究を実施することを目的としている。実験系からは,小野は,ラット視床背内側核の情動発現および運動学習における役割を,澤口は,サル前頭葉の作動記憶および異種感覚情報の統合における役割をニューロンレベルで明らかにした。岩田は,相貌失認患者の弁別閾を測定するための神経心理学的検査法を確立した。下条は,心理物理学的アプローチにより,再認家庭における記憶の確信度と呈示刺激に対する高感度との間に正の相関関係があることを報告した。理論(計算論的神経科学)系からは,倉田は,自己組織化による多重脳マップ形成モデルを,森田は,側抑制による時系列パターンの想起速度の制御方法および軌道アトラクタを用いた時系列パターンの認知モデルを構築した。安西は,遅延見本合わせ課題遂行中のラット聴覚野および海馬体ニューロンの同時記録を行なった。また,ロボットに情動を組み込むことにより,より自律的な行動制御ができるこを明らかにした。今後は,これら神経生理学的,ならびに神経心理学的手法により,生物学的な作動原理を明らかにするとともに,計算論的にその作動原理のグローバルな実現,すなわち統一のとれた一つの脳として,脳の各モジュールがどのように機能しているかその可能性を明らかにしていく予定である。

Research Products

(25 results)

All Other

All Publications (25 results)

[Publications] Oyoshi,T.,Nishijo,H.,Asakura,T.,Takamura,Y.and Ono,T.: "Emotional and behavioral correlates of mediodorsal thalamic neurons during associative learning in rats." Journal of Neuroscience. 16. 5812-5829 (1996)
[Publications] Kobayashi,T.,Nishijo,H.,Fukuda,M.,Bures,J.,and Ono,T.: "Task-dependent representations in rat hippocampal place neurons." Journal of Neurophysiology. (in press). (1997)
[Publications] Kondoh,T.,Nishijo,H.,Takamura,Y.,Kawanishi,C.,Torii,K.and Ono,T.: "Increased histidine preference during specific alteration of rhythm of environmental temperature stress in rats" Behavioral Neuroscience. 110. 1187-1192 (1996)
[Publications] Yamashima,T.,Saido,T.C.,Takita,M.,Miyazawa,A.,et al.: "Transient brain ischemia provokes Ca2+,PIP2 and calpain responses prior to delayed neuronal death in monkeys" Europena Journal of Neuroscience. 8. 1932-1944 (1996)
[Publications] 小野武年,田渕英一: "大脳辺縁系-ヒトと動物における意義-" 神経研究の進歩. 40. 1000-1007 (1996)
[Publications] 上野照子,小野武年: "側頭葉と情動." Clinical Neuroscience. 14. 1122-1126 (1996)
[Publications] 村上聡,森田昌彦: "局所抑制型神経回路網における時系列パターンの想起の制御" 第11回生体・生理工学シンポジウム論文集. 105-108 (1996)
[Publications] 伊達章,倉田耕治,甘利俊一: "可変閾値をもつランダム対象結合神経回路の平衡状態の数" 日本応用数理学会論文誌. 6. 15-28 (1996)
[Publications] 三戸健史,倉田耕治: "ダイナミックリンクによる画像どうしのマッチング" 日本神経回路学会誌. 3-2. 51-57 (1996)
[Publications] 青西亨,倉田耕治: "ダイナミックリンクによる画像の部分どうしのマッチング" 日本神経回路学会誌. 3-3. 90-97 (1996)
[Publications] Yamamoto,J.,and Anzai,Y.: "Biologically inspired learnable autonomous robot" Proceedings of The Second ECPD International Conference on Advanced Robotics,Intelligent Automation and Active Systems.149-154 (1996)
[Publications] Yamamoto,J.,and Anzai,Y.: "Autonomous robot with evolving algorithm based on biological systems." Proceedings of International Conference on Evolvable Systems : from Biology to Hardware.234-246 (1996)
[Publications] Sakurai,Y.,Momose,T.,Iwata,M.Ishikawa,T.,Sato,T.,Kanazawa,I: "Regional cerebral blood flow in the covert reading of kana words : A comparison with the study of reading aloud tasks." Eur.Neurol.36. 237-239 (1996)
[Publications] Sakurai,Y.,Momose,T.,Iwata,M.Sasaki,Y.,Kanazawa,I: "Activation of prefrontal and posterior superior temporal areas in visual calculation" J.Neurol.Sci.139. 89-94 (1996)
[Publications] Kitazaki,M.and Shimojo,S.: "'Generic view principle' for three-diemensional motion perception : optics and inverse optics of a single straight bar." Perception. 25. 797-814 (1996)
[Publications] Tanaka,Y.and Shimojo,S.: "Location vs feature : reaction time reveals dissociation between two visual functions." Vision Research. 36. 2125-2140 (1996)
[Publications] Hasegawa,R.,Sawaguchi,T.and Kubota,K.: "Monkey prefrontal neuronal activity coding the forthcoming saccade in an oculomotor delayed matching-to-sample task." J.Neurophysiol.in press.
[Publications] Morita,M.: "Computational study on the neural mechanism of sequential pattern memory." Cognitive Brain Research. in press.
[Publications] Nishijo,H.,Tamura,R.,Eifuku,S.and Ono,T.: "Hippocampal neuronal responsiveness to complex and simple conditional association tasks in monkeys. In : Perception,Memory and Emotion : Frontier in Neuroscience." Ono,T.,McNaughton,B.L.,Molotchnikoff,S.,Rolls,E.T.,and Nisijo,H. (Eds.) Elsevier,Oxford., 251-267 (1996)
[Publications] Ono,T.,Nishijo,H.,Eifuku,S.,Kobayashi,T.and Tamura,R.: "The role of the amygdala and the mediodorsal thalamic nucleus in emotional memory. In : Brain Processes and Memory." K.Ishikawa,J.L.McGaugh,and H.Sakata (eds.),Elsevier,Tokyo, 187-201 (1996)
[Publications] Iwata,M.,Sakurai,Y.,Momose,T.: "Functional mapping of the cerebral cortex responsible for reading in the Japanese language. In : Recent Advances in Clinical Neurophysiology." Kimura,J.,and Shibasaki,H., (Eds.),Excerpta Meduica,Amsterdam., 236-240 (1996)
[Publications] Shimojo,S.,Tanaka,Y.,Hikosaka,O.and Miyauchi,S.: "Vision,Attention,and Action : Inhibition and Facilitation in Sensory-Motor Links Revealed by the Reaction Time and the Line Motion. In : Attention and Performance XVI" Inui,T.and McClelland (Eds.),the MIT Press,London., 597-630 (1996)
[Publications] 小野武年,西条寿夫: "大脳辺縁系と高次脳機能,小児神経学の進歩第25集." 日本小児神経学会卒後教育委員会編,診断と治療社, 66-83 (1996)
[Publications] Ono,T.,Nishijo,H.,Tamura,R.and Uwano,T.: "Neural mechanisms of episodic memory in the monkey septo-hippocampal systems. In Integrative and Molecular Approach to Brain Function" M.Ito and Y.Miyashita (Eds.),Elsevier Science., 205-221 (1996)
[Publications] Osawa,M.,Iijima,M.,Nageishi,Y.,Ushijima,R.,Iwata,M.: "Automatic and controlled processing in normal aging and dementia. In : Recent Advances in Event-related Potential Research." Ogura,C.,Koga,Y.,and Shimokochi,M., (Eds.),Elsevier Sci.BV,Amsterdam, 743-750 (1996)

1996 Fiscal Year Annual Research Report

情動と思考のメカニズム

Principal Investigator

小野 武年 富山医科薬科大学, 医学部, 教授 (50019577)

Research Products

[Publications] Oyoshi,T.,Nishijo,H.,Asakura,T.,Takamura,Y.and Ono,T.: "Emotional and behavioral correlates of mediodorsal thalamic neurons during associative learning in rats." Journal of Neuroscience. 16. 5812-5829 (1996)

[Publications] Kobayashi,T.,Nishijo,H.,Fukuda,M.,Bures,J.,and Ono,T.: "Task-dependent representations in rat hippocampal place neurons." Journal of Neurophysiology. (in press). (1997)

[Publications] Kondoh,T.,Nishijo,H.,Takamura,Y.,Kawanishi,C.,Torii,K.and Ono,T.: "Increased histidine preference during specific alteration of rhythm of environmental temperature stress in rats" Behavioral Neuroscience. 110. 1187-1192 (1996)

[Publications] Yamashima,T.,Saido,T.C.,Takita,M.,Miyazawa,A.,et al.: "Transient brain ischemia provokes Ca2+,PIP2 and calpain responses prior to delayed neuronal death in monkeys" Europena Journal of Neuroscience. 8. 1932-1944 (1996)

[Publications] 小野武年,田渕英一: "大脳辺縁系-ヒトと動物における意義-" 神経研究の進歩. 40. 1000-1007 (1996)

[Publications] 上野照子,小野武年: "側頭葉と情動." Clinical Neuroscience. 14. 1122-1126 (1996)

[Publications] 村上聡,森田昌彦: "局所抑制型神経回路網における時系列パターンの想起の制御" 第11回生体・生理工学シンポジウム論文集. 105-108 (1996)

[Publications] 伊達章,倉田耕治,甘利俊一: "可変閾値をもつランダム対象結合神経回路の平衡状態の数" 日本応用数理学会論文誌. 6. 15-28 (1996)

[Publications] 三戸健史,倉田耕治: "ダイナミックリンクによる画像どうしのマッチング" 日本神経回路学会誌. 3-2. 51-57 (1996)

[Publications] 青西亨,倉田耕治: "ダイナミックリンクによる画像の部分どうしのマッチング" 日本神経回路学会誌. 3-3. 90-97 (1996)

[Publications] Yamamoto,J.,and Anzai,Y.: "Biologically inspired learnable autonomous robot" Proceedings of The Second ECPD International Conference on Advanced Robotics,Intelligent Automation and Active Systems.149-154 (1996)

[Publications] Yamamoto,J.,and Anzai,Y.: "Autonomous robot with evolving algorithm based on biological systems." Proceedings of International Conference on Evolvable Systems : from Biology to Hardware.234-246 (1996)

[Publications] Sakurai,Y.,Momose,T.,Iwata,M.Ishikawa,T.,Sato,T.,Kanazawa,I: "Regional cerebral blood flow in the covert reading of kana words : A comparison with the study of reading aloud tasks." Eur.Neurol.36. 237-239 (1996)

[Publications] Sakurai,Y.,Momose,T.,Iwata,M.Sasaki,Y.,Kanazawa,I: "Activation of prefrontal and posterior superior temporal areas in visual calculation" J.Neurol.Sci.139. 89-94 (1996)

[Publications] Kitazaki,M.and Shimojo,S.: "'Generic view principle' for three-diemensional motion perception : optics and inverse optics of a single straight bar." Perception. 25. 797-814 (1996)

[Publications] Tanaka,Y.and Shimojo,S.: "Location vs feature : reaction time reveals dissociation between two visual functions." Vision Research. 36. 2125-2140 (1996)

[Publications] Hasegawa,R.,Sawaguchi,T.and Kubota,K.: "Monkey prefrontal neuronal activity coding the forthcoming saccade in an oculomotor delayed matching-to-sample task." J.Neurophysiol.in press.

[Publications] Morita,M.: "Computational study on the neural mechanism of sequential pattern memory." Cognitive Brain Research. in press.

[Publications] Ono,T.,Nishijo,H.,Eifuku,S.,Kobayashi,T.and Tamura,R.: "The role of the amygdala and the mediodorsal thalamic nucleus in emotional memory. In : Brain Processes and Memory." K.Ishikawa,J.L.McGaugh,and H.Sakata (eds.),Elsevier,Tokyo, 187-201 (1996)

[Publications] Iwata,M.,Sakurai,Y.,Momose,T.: "Functional mapping of the cerebral cortex responsible for reading in the Japanese language. In : Recent Advances in Clinical Neurophysiology." Kimura,J.,and Shibasaki,H., (Eds.),Excerpta Meduica,Amsterdam., 236-240 (1996)

[Publications] Shimojo,S.,Tanaka,Y.,Hikosaka,O.and Miyauchi,S.: "Vision,Attention,and Action : Inhibition and Facilitation in Sensory-Motor Links Revealed by the Reaction Time and the Line Motion. In : Attention and Performance XVI" Inui,T.and McClelland (Eds.),the MIT Press,London., 597-630 (1996)

[Publications] 小野武年,西条寿夫: "大脳辺縁系と高次脳機能,小児神経学の進歩第25集." 日本小児神経学会卒後教育委員会編,診断と治療社, 66-83 (1996)

[Publications] Ono,T.,Nishijo,H.,Tamura,R.and Uwano,T.: "Neural mechanisms of episodic memory in the monkey septo-hippocampal systems. In Integrative and Molecular Approach to Brain Function" M.Ito and Y.Miyashita (Eds.),Elsevier Science., 205-221 (1996)

[Publications] Osawa,M.,Iijima,M.,Nageishi,Y.,Ushijima,R.,Iwata,M.: "Automatic and controlled processing in normal aging and dementia. In : Recent Advances in Event-related Potential Research." Ogura,C.,Koga,Y.,and Shimokochi,M., (Eds.),Elsevier Sci.BV,Amsterdam, 743-750 (1996)

小野武年富山医科薬科大学, 医学部, 教授 (50019577)