1998 Fiscal Year Annual Research Report

情動と思考のメカニズム

Research Project

Project/Area Number	08279105
Research Category	Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution	Toyama Medical and Pharmaceutical University
Principal Investigator	小野武年富山医科薬科大学, 医学部, 教授 (50019577)
Co-Investigator(Kenkyū-buntansha)	澤口俊之北海道大学, 文学部, 助教授 (00183830) 森田昌彦筑波大学, 電子・情報工学部, 講師 (00222349) 倉田耕治大阪大学, 基礎工学部, 講師 (40170071) 岩田誠東京女子医科大学, 脳神経センター, 教授 (90107665) 安西祐一郎慶応大学, 理工学部, 教授 (40051875)
Keywords	情動 / 思考 / 大脳辺縁系 / 前頭葉 / 失認 / 光計測法 / 時系列パターン / 多重脳マップ
Research Abstract	本研究は,思考と情動を脳内各機能系の最高位の統合システムとみなし,その機能原理について生物学的および計算論的側面の両面から解明に取り組むものである。生物学的側面では,小野は,サル扁桃体ニューロンの応答性から,扁桃体は,単純な感覚刺激だけでなく文脈や空間情報を含むすべての情報の最終的な価値評価や意味認知に関与し,これらトップダウン情報により脳の情報処理システムを制御している可能性を示唆した。澤口は,サル前頭葉ニューロンの視覚刺激に対する応答潜時および運動の各種パラメータに対する相関を解析することにより,視覚情報の受容→行動的意味の検出→運動の選択・決断→運動情報の生成という一連の情報処理過程が前頭葉で行われていることを明らかにした。岩田は,光トポグラフィー法を用いて脳血流を計測し,書字課題では主に左半球ブローカ野とウエルニッケ野で脳血流が増加するが,運動野など他の領野と比較して脳血流の時間的変化が遅いことなどを明らかにした。河村は,地理認知障害を街並失認および道順障害に分類し,それぞれ側頭後頭葉内側-海馬系および頭頂後頭葉内側-海馬系の障害であることを明らかにした。計算論的側面では,倉田は,昨年度のモデルを自己組織連続多重マップモデルに発展させ,1)2種類の情報を合せ持つ入力からそれらの情報を分離抽出できる,2)このモデルに特有な情報空間の構造に基づいて良好な汎化能力をもつことを示した。森田は,中間層を導入した改良型時系列パターンモデル,および皮質-嗅皮質間の相互作用に基づく対連合記憶の神経回路モデルを構築した。安西は,光計測法による画像データを統計学的に解析することにより,膜電位変化を単一ニューロンレベルで抽出する手法を確立した。今後は,第4班ではこれまで得られた生物学的および計算論的研究の両成果の統合を目指して研究を続けていく予定である。

Research Products
(42 results)

All Other

All Publications (42 results)

[Publications] Nishijo,H.,Ono,T.,Uwano,T.,Kondoh,T.,and Torii,K.: "Hypothalamic and amygdalar neuronal responses to various sapid solutions during ingestive behavior in rats." J.Nutrition. (in press). (1999)
[Publications] Matsumura,N.,Nishijo,H.,Tamura,R.,Eifuku,S.,Endo,S.,and Ono,T.: "Spatial and task-dependent neuronal responses during real and virtual translocation in the monkey hippocampal formation." J.Neurosci.(in press). (1999)
[Publications] Nishijo,H.,Uwano,T.,Tamura,R.and Ono,T.: "Gustatory and multimodal neuronal responses in the amygdala during licking and discrimination of sensory stimuli in awake rats." J.Neurophysiol.79. 21-36 (1998)
[Publications] Kondoh,T.,Mori,M.,Ono,T.,and Trii,K.: "Mechanisms of umami taste preference and aversion in rats." J.Nutrition. (in press). (1999)
[Publications] 西条寿夫,小野武年: "ニューロン活動慢性記録法." 医学のあゆみ. 184. 625-633 (1998)
[Publications] Ono,T.,and Nishijo,H.: "Active spatial information processing in the septo-hippocampal system." Hippocampus. (in press). (1999)
[Publications] 森田昌彦,村上聡: "非単調神経回路網による時系列パターンの認識." 電子情報通信学会論文誌(D-II),. 81. 1679-1688 (1998)
[Publications] 森田ひろみ,森田昌彦: "形と色の統合における局所結合の働き." 心理学研究. 69. 358-366 (1998)
[Publications] Aonishi,T.,Kurata,K.: "A phase locking theory of matching between rotated images by a dynamic link matching." Biol.Cybern.(in press). (1998)
[Publications] 白倉準,倉田耕治.: "入力情報の連続的対応による自己組織多重マップの引き込み." 電子情報通信学会論文誌D-II. J81. 2421-2429 (1998)
[Publications] 堤由紀子,岩田誠: "経頭蓋ドップラー脳血流測定." Brain Medical. 10. 183-189 (1988)
[Publications] 小泉英明,牧敦,山下優一,山本剛,岩田誠,吉沢浩志,渡辺英寿: "光トポグラフィーの原理と応用" Brain Medical. 10. 191-195 (1988)
[Publications] Hagino,H.,Tabuchi,E.,Kurachi,M.,Saitoh,O.,Sun,Y.,Kondoh,T.,Ono,T.and Torii,K.: "Effects of D_2 dopamine receptor agonist and antagonist on brain activity in the rat assessed by functional magnetic resonance imaging." Brain Res.813. 367-373 (1998)
[Publications] Ikeda,H.,Nishijo,H.,Miyamoto,K.,Tamura,R.,Endo,S.and Ono,T.: "Generators of visual evoked potentials investigated by dipole tracing in the human occipital cortex." Neuroscience. 84. 723-739 (1998)
[Publications] Shibata,K.,Osawa.M.,and Iwata,M.: "Pattern reversal visual evoked potentials in migraine with aura and migraine aura without headache." Cephalalgia. 18. 319-323 (1998)
[Publications] Sakurai,Y.,Murayama,S.,Fukusako,Y.,Bando,M.,Iwata,M.,Inoue,K.: "Progressive aphemia in a patient with Pick's disease: a neuropsychological and anatomic study." J.Neurol.Sci.159. 156-161 (1998)
[Publications] Murakami,S.,Morita,M.,and Sakamoto,N.: "Effects of D_2 dopamine receptor agonist and antagonist on brain activity in the rat assessed by functional magnetic resonance imaging." Brain Res.813. 367-373 (1998)
[Publications] Murakami,S.,Morita,M.,and Sakamoto,N.: "Effects of D_2 dopamine receptor agonist and antagonist on brain activity in the rat assessed by functional magnetic resonance imaging." Brain Res.813. 367-373 (1998)
[Publications] Aonishi,T.,and Kurata,K.: "Deformation theory of the dynamic link matching." Neural Computation. 10. 651-669 (1998)
[Publications] Aonishi,T.,and Kurata,K.: "A phase locking theory of matching between rotated images by a dynamic link matching" Biol.Cybern.78. 253-264 (1998)
[Publications] Mimura,K.,Okada,M.,and Kurata,K.: "Robustness to noise of associative memory using nonmonotonic analogue neurons." IEICE Transaction on Information and Systems,E81-D. No.8. 928-932 (1998)
[Publications] Hasegawa,R.,Sawaguchi,T.and Kubota,K.: "Monkey prefrontal neuronal activity coding the forthcoming saccade in an oculomotor delayed matching-to-sample task." J.Neurophysiol.79. 322-333 (1998)
[Publications] Sawaguchi,T.: "Attenuation of delay-period activity of prefrontal cortical neurons by an a2-adrenergic antagonist during an oculomotor delayed-response task in monkeys." J.Neurophysiol.80. 2200-2205 (1998)
[Publications] Sawaguchi,T.,and Yamane,I..: "Properties of neuronal activity for visuospatial memory in the monkey dorso-lateral prefrontal cortex." J.Neurophysiol.(in press). (1999)
[Publications] Kawamura,M.,and Mochizuki,S.: "Primary progressive apraxia." Neurology. (in press). (1999)
[Publications] Shiota,J.,Kawamura,M.,Takahashi,N.,Isono,O.,and Sugita,K.: "Prosopagnosia: a clinical,neuroradiological and pathological study." Cortex. (in press). (1999)
[Publications] 永井知代子、岩田誠: "記憶の脳科学" 心療内科. 2(6). 441-447 (1998)
[Publications] 岩田誠: "言語の脳機構" 音声言語医学. 39. 215-220 (1998)
[Publications] 田村了以,小野武年: "記憶と扁桃体.最新脳と神経科学シリーズ,第8巻.高倉公明,宮本忠雄,監修.高橋徹,設楽信行,清水輝夫,編集." メジカルビュー社,東京., 142-150 (1998)
[Publications] Ono,T.,and Nishijo,H.: "Neurophysiological basis of emotion in primates: neuronal responses in the monkey amygdala and anterior cingulate cortex.(in press)" The Cognitive Neurosciences,2nd ed.,by M.S.Gazzaniga(Ed.),MIT Press, (1999)
[Publications] 末光厚夫,森田昌彦: "第13回生体・生理工学シンポジウム論文集" 対連合記憶の形成機構のモデル化, 169-172 (1998)
[Publications] Murakami,S.,Morita,M.,and Sakamoto,N.: "Proceedings of the 1998 International Conference on Neural Information Processing" Recognition of spatiotemporal patterns using a nonmonotone neural network with hidden neurons., 287-290 (1998)
[Publications] Zhong Y.M.,Nishijo H.,Uwano T.,Yamaguchi H.,and Ono T.: "Red ginseng ameliorates place learning deficits in aged rats and in young rats with selective hippocampal lesions." Advances in Ginseng Research-Proc.of 7th Int.Symp.on Ginseng,by Huh H.,Choi K.J.,and Kim Y.C.(Eds.),The Korean Society of Ginseng,Korea, 1-11 (1998)
[Publications] 小野武年,田村了以,中田恭史,栗本博昭: "脳虚血ラットの場所学習・記憶障害に対するT-588の改善効果." 「虚血性神経細胞死」金澤一郎,吉岡亨,山下純宏監修,サイメッド・パブリケーションズ,東京,1998., 132-146 (1998)
[Publications] Kikuchi,M.,Osawa,M.,Usjijima,R.,and Iwata,M.: "Topographic mapping of midlatency auditory responses depends on actual cognitive task." Brain Topography Today,by Koga,Y.,Nagata,K.,Hirata,K.(Eds.),Elsevier Science B.V.,Amsterdam., 141-145. (1998)
[Publications] Sakurai,Y.,Iwata,M.,and Momose,T.: "PET activation studies on neural mechanism of reading in the Japanese language." Brain Topography Today,by Koga,Y.,Nagata,K.,Hirata,K.(Eds.),Elsevier Science B.V.,Amsterdam., 209-213. (1998)
[Publications] 永井知代子、岩田誠: "一過性全健忘.最新脳と神経科学シリーズ,第8巻.高倉公明,宮本忠雄,監修.高橋徹,設楽信行,清水輝夫,編集." メジカルビュー社,東京., 190-200. (1998)
[Publications] Yamamoto,J.,Okanda,M.,Sasaki,H.,Tsukada,M.and Anzai,Y.: "The effect of hippocampal activity to auditory evoked responses in guinea pig revealed by optical imaging." Proc.of The 5th Int.Conf.on Neural Information Processing ICONIP'98, 1547-1550 (1998)
[Publications] Osawa,M.,Usjijima,R.,and Iwata,M.: "A comparison of topographic mapping(TP)of auditory and visual NA and its age-related changes." Brain Topography Today,by Koga,Y.,Nagata,K.,Hirata,K.(Eds.),Elsevier Science B.V.,Amsterdam., 558-562. (1998)
[Publications] Iijima,M.,Osawa,M.,Kubota,M.,Sawada,K.,Komaki,R.,and Iwata,M.: "Effects of perfume on cognitive function evaluated by event-related potentials." :Brain Topography Today,by Koga,Y.,Nagata,K.,Hirata,K.(Eds.),Elsevier Science B.V.,Amsterdam., 744-749. (1998)
[Publications] Takahashi,S.,Yamamoto,J.and Anzai,Y.: "Visualization tools for Firing Correlation based on the Joint PSTH" Proc.of The 5th Int.Conf.on Neural Information Processing ICONIP'98, 1555-1558 (1998)
[Publications] Kawamura,M.: "Neurobehavioral stroke syndromes,chronic syndromes: perceptual aspects" Cerebrovascular Disease,Ginsberg,M.D.,and Bogousslavski,J.(Eds.),Blackwell: Cambridge., 1160-1164 (1998)

1998 Fiscal Year Annual Research Report

情動と思考のメカニズム

Principal Investigator

小野 武年 富山医科薬科大学, 医学部, 教授 (50019577)

Research Products

[Publications] Nishijo,H.,Ono,T.,Uwano,T.,Kondoh,T.,and Torii,K.: "Hypothalamic and amygdalar neuronal responses to various sapid solutions during ingestive behavior in rats." J.Nutrition. (in press). (1999)

[Publications] Matsumura,N.,Nishijo,H.,Tamura,R.,Eifuku,S.,Endo,S.,and Ono,T.: "Spatial and task-dependent neuronal responses during real and virtual translocation in the monkey hippocampal formation." J.Neurosci.(in press). (1999)

[Publications] Nishijo,H.,Uwano,T.,Tamura,R.and Ono,T.: "Gustatory and multimodal neuronal responses in the amygdala during licking and discrimination of sensory stimuli in awake rats." J.Neurophysiol.79. 21-36 (1998)

[Publications] Kondoh,T.,Mori,M.,Ono,T.,and Trii,K.: "Mechanisms of umami taste preference and aversion in rats." J.Nutrition. (in press). (1999)

[Publications] 西条寿夫,小野武年: "ニューロン活動慢性記録法." 医学のあゆみ. 184. 625-633 (1998)

[Publications] Ono,T.,and Nishijo,H.: "Active spatial information processing in the septo-hippocampal system." Hippocampus. (in press). (1999)

[Publications] 森田昌彦,村上聡: "非単調神経回路網による時系列パターンの認識." 電子情報通信学会論文誌(D-II),. 81. 1679-1688 (1998)

[Publications] 森田ひろみ,森田昌彦: "形と色の統合における局所結合の働き." 心理学研究. 69. 358-366 (1998)

[Publications] Aonishi,T.,Kurata,K.: "A phase locking theory of matching between rotated images by a dynamic link matching." Biol.Cybern.(in press). (1998)

[Publications] 白倉準,倉田耕治.: "入力情報の連続的対応による自己組織多重マップの引き込み." 電子情報通信学会論文誌D-II. J81. 2421-2429 (1998)

[Publications] 堤由紀子,岩田誠: "経頭蓋ドップラー脳血流測定." Brain Medical. 10. 183-189 (1988)

[Publications] 小泉英明,牧敦,山下優一,山本剛,岩田誠,吉沢浩志,渡辺英寿: "光トポグラフィーの原理と応用" Brain Medical. 10. 191-195 (1988)

[Publications] Hagino,H.,Tabuchi,E.,Kurachi,M.,Saitoh,O.,Sun,Y.,Kondoh,T.,Ono,T.and Torii,K.: "Effects of D_2 dopamine receptor agonist and antagonist on brain activity in the rat assessed by functional magnetic resonance imaging." Brain Res.813. 367-373 (1998)

[Publications] Ikeda,H.,Nishijo,H.,Miyamoto,K.,Tamura,R.,Endo,S.and Ono,T.: "Generators of visual evoked potentials investigated by dipole tracing in the human occipital cortex." Neuroscience. 84. 723-739 (1998)

[Publications] Shibata,K.,Osawa.M.,and Iwata,M.: "Pattern reversal visual evoked potentials in migraine with aura and migraine aura without headache." Cephalalgia. 18. 319-323 (1998)

[Publications] Sakurai,Y.,Murayama,S.,Fukusako,Y.,Bando,M.,Iwata,M.,Inoue,K.: "Progressive aphemia in a patient with Pick's disease: a neuropsychological and anatomic study." J.Neurol.Sci.159. 156-161 (1998)

[Publications] Murakami,S.,Morita,M.,and Sakamoto,N.: "Effects of D_2 dopamine receptor agonist and antagonist on brain activity in the rat assessed by functional magnetic resonance imaging." Brain Res.813. 367-373 (1998)

[Publications] Murakami,S.,Morita,M.,and Sakamoto,N.: "Effects of D_2 dopamine receptor agonist and antagonist on brain activity in the rat assessed by functional magnetic resonance imaging." Brain Res.813. 367-373 (1998)

[Publications] Aonishi,T.,and Kurata,K.: "Deformation theory of the dynamic link matching." Neural Computation. 10. 651-669 (1998)

[Publications] Aonishi,T.,and Kurata,K.: "A phase locking theory of matching between rotated images by a dynamic link matching" Biol.Cybern.78. 253-264 (1998)

[Publications] Mimura,K.,Okada,M.,and Kurata,K.: "Robustness to noise of associative memory using nonmonotonic analogue neurons." IEICE Transaction on Information and Systems,E81-D. No.8. 928-932 (1998)

[Publications] Hasegawa,R.,Sawaguchi,T.and Kubota,K.: "Monkey prefrontal neuronal activity coding the forthcoming saccade in an oculomotor delayed matching-to-sample task." J.Neurophysiol.79. 322-333 (1998)

[Publications] Sawaguchi,T.: "Attenuation of delay-period activity of prefrontal cortical neurons by an a2-adrenergic antagonist during an oculomotor delayed-response task in monkeys." J.Neurophysiol.80. 2200-2205 (1998)

[Publications] Sawaguchi,T.,and Yamane,I..: "Properties of neuronal activity for visuospatial memory in the monkey dorso-lateral prefrontal cortex." J.Neurophysiol.(in press). (1999)

[Publications] Kawamura,M.,and Mochizuki,S.: "Primary progressive apraxia." Neurology. (in press). (1999)

[Publications] Shiota,J.,Kawamura,M.,Takahashi,N.,Isono,O.,and Sugita,K.: "Prosopagnosia: a clinical,neuroradiological and pathological study." Cortex. (in press). (1999)

[Publications] 永井知代子、岩田 誠: "記憶の脳科学" 心療内科. 2(6). 441-447 (1998)

[Publications] 岩田 誠: "言語の脳機構" 音声言語医学. 39. 215-220 (1998)

[Publications] 田村了以,小野武年: "記憶と扁桃体.最新 脳と神経科学シリーズ,第8巻.高倉公明,宮本忠雄,監修.高橋徹,設楽信行,清水輝夫,編集." メジカルビュー社,東京., 142-150 (1998)

[Publications] Ono,T.,and Nishijo,H.: "Neurophysiological basis of emotion in primates: neuronal responses in the monkey amygdala and anterior cingulate cortex.(in press)" The Cognitive Neurosciences,2nd ed.,by M.S.Gazzaniga(Ed.),MIT Press, (1999)

[Publications] 末光厚夫,森田昌彦: "第13回生体・生理工学シンポジウム論文集" 対連合記憶の形成機構のモデル化, 169-172 (1998)

[Publications] Murakami,S.,Morita,M.,and Sakamoto,N.: "Proceedings of the 1998 International Conference on Neural Information Processing" Recognition of spatiotemporal patterns using a nonmonotone neural network with hidden neurons., 287-290 (1998)

[Publications] 小野武年,田村了以,中田恭史,栗本博昭: "脳虚血ラットの場所学習・記憶障害に対するT-588の改善効果." 「虚血性神経細胞死」金澤一郎,吉岡亨,山下純宏監修,サイメッド・パブリケーションズ,東京,1998., 132-146 (1998)

[Publications] Kikuchi,M.,Osawa,M.,Usjijima,R.,and Iwata,M.: "Topographic mapping of midlatency auditory responses depends on actual cognitive task." Brain Topography Today,by Koga,Y.,Nagata,K.,Hirata,K.(Eds.),Elsevier Science B.V.,Amsterdam., 141-145. (1998)

[Publications] Sakurai,Y.,Iwata,M.,and Momose,T.: "PET activation studies on neural mechanism of reading in the Japanese language." Brain Topography Today,by Koga,Y.,Nagata,K.,Hirata,K.(Eds.),Elsevier Science B.V.,Amsterdam., 209-213. (1998)

[Publications] 永井知代子、岩田 誠: "一過性全健忘.最新 脳と神経科学シリーズ,第8巻.高倉公明,宮本忠雄,監修.高橋徹,設楽信行,清水輝夫,編集." メジカルビュー社,東京., 190-200. (1998)

[Publications] Yamamoto,J.,Okanda,M.,Sasaki,H.,Tsukada,M.and Anzai,Y.: "The effect of hippocampal activity to auditory evoked responses in guinea pig revealed by optical imaging." Proc.of The 5th Int.Conf.on Neural Information Processing ICONIP'98, 1547-1550 (1998)

[Publications] Osawa,M.,Usjijima,R.,and Iwata,M.: "A comparison of topographic mapping(TP)of auditory and visual NA and its age-related changes." Brain Topography Today,by Koga,Y.,Nagata,K.,Hirata,K.(Eds.),Elsevier Science B.V.,Amsterdam., 558-562. (1998)

[Publications] Iijima,M.,Osawa,M.,Kubota,M.,Sawada,K.,Komaki,R.,and Iwata,M.: "Effects of perfume on cognitive function evaluated by event-related potentials." :Brain Topography Today,by Koga,Y.,Nagata,K.,Hirata,K.(Eds.),Elsevier Science B.V.,Amsterdam., 744-749. (1998)

[Publications] Takahashi,S.,Yamamoto,J.and Anzai,Y.: "Visualization tools for Firing Correlation based on the Joint PSTH" Proc.of The 5th Int.Conf.on Neural Information Processing ICONIP'98, 1555-1558 (1998)

[Publications] Kawamura,M.: "Neurobehavioral stroke syndromes,chronic syndromes: perceptual aspects" Cerebrovascular Disease,Ginsberg,M.D.,and Bogousslavski,J.(Eds.),Blackwell: Cambridge., 1160-1164 (1998)

小野武年富山医科薬科大学, 医学部, 教授 (50019577)

[Publications] 永井知代子、岩田誠: "記憶の脳科学" 心療内科. 2(6). 441-447 (1998)

[Publications] 岩田誠: "言語の脳機構" 音声言語医学. 39. 215-220 (1998)

[Publications] 田村了以,小野武年: "記憶と扁桃体.最新脳と神経科学シリーズ,第8巻.高倉公明,宮本忠雄,監修.高橋徹,設楽信行,清水輝夫,編集." メジカルビュー社,東京., 142-150 (1998)

[Publications] 永井知代子、岩田誠: "一過性全健忘.最新脳と神経科学シリーズ,第8巻.高倉公明,宮本忠雄,監修.高橋徹,設楽信行,清水輝夫,編集." メジカルビュー社,東京., 190-200. (1998)