2001 Fiscal Year Final Research Report Summary
Molecular Mechanisms of Genomic Instability and DNA Repair
| Project/Area Number |
08280103
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas (A)
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| Allocation Type | Single-year Grants |
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| Research Institution | Osaka University |
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Principal Investigator |
HANAOKA Fumio Osaka Univ., IMCB, Professor, 細胞生体工学センター, 教授 (50012670)
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| Co-Investigator(Kenkyū-buntansha) |
MAKI Hisaji Nara Inst. Sci. Tech., Professor, バイオ, 教授 (20199649)
SHINAGAWA Hideo Osaka Univ., RIMD, Professor, 微生物病研究所, 教授 (40029799)
TANAKA Kiyoji Osaka Univ., IMCB, Professor, 細胞生体工学センター, 教授 (80144450)
YANAGIDA Mitsuhiro Kyoto Univ., Grad. Sch. Sci., Professor, 大学院・生命科学研究科, 教授 (80025428)
YASUI Akira Tohoku Univ., IDAC, Professor, 加齢医学研究所, 教授 (60191110)
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| Project Period (FY) |
1996 – 2000
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| Keywords | DNA repair / Nucleotide excision repair / Recombination repair / Homologous recombination / Mutagenesis / Carcinogenesis / Genetic disease |
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| Research Abstract |
We have studied various DNA repair mechanisms and the consequence of their defects from molecular to organism level. We categorized our studies into the following three subjects.
1. Mechanisms of excision repair and molecular consequence of their defects.
2. Mechanisms of homologous recombination and recombination repair.
3. Molecular mechanisms of mutagenesis.
In order to support this research project effectively, the advisory committee has conducted the following activities.
1. We have financially supported a couple of research groups, when we found that it is better to support them with respect to the progress bf those research areas.
2. We have published research forums and had meetings with all the members in order to facilitate exchange of information.
3. We have financially supported related two workshops, which have been held annually. One is "Workshop on Genetic Recombination and Its Regulation", and the other is "Workshop on DNA Repair and Mutagenesis".
4. We have held advisory committee twice per year in order to evaluate the outcomes of the research groups and to obtain suggestions for future research direction.
5. We have supported researchers to attend international meetings. We have also invited foreign researchers to Japan in order to facilitate the exchange of information.
6. We have published at the final year a book, which describes research activities of all the members of this project including the list of related publications and copies of their representative paper.
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[Publications] Sugasawa, K., Masutani, C., Uchida, A., Maekawa, T., van der Spek, P. J., Bootsma, D., Hoeijmakers, J. H. J., and Hanaoka, F.: "HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro."Mol. Cell. Biol.. 16(9). 4852-4861 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Masutani, C., Araki, M., Sugasawa, K., van der Spek, P. J., Yamada, A., Uchida, A., Maekawa, T., Bootsma, D., Hoeijmakers, J. H. J., and Hanaoka, F.: "Identification and characterization of XPC-binding domain of hHR23B."Mol. Cell. Biol.. 17(12). 6915-6923 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Masutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S., and Hanaoka, F.: "Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity."EMBO J.. 18(12). 3491-3501 (1999)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., and Hanaoka, F.: "The XPV(xeroderma pigmentosum variant) gene encodes human DNA polymerase η."Nature. 399(6737). 700-704 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] Sugasawa, K., Okamoto, T., Shimizu, Y., Masutani, C., Iwai, S., and Hanaoka, F.: "Multi-step recognition mechanism in the global genomic nucleotide excision repair."Genes Dev.. 15(5). 507-521 (2001)
Description
「研究成果報告書概要(欧文)」より
