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1998 Fiscal Year Final Research Report Summary

A study of molecular pathology in experimental Sjogren's syndrome in mice

Research Project

Project/Area Number 08407057
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

HAYASHI Yoshio  The University of Tokushima, School of Dentistry, Professor, 歯学部, 教授 (00127854)

Co-Investigator(Kenkyū-buntansha) YANAGAI Kumiko  The University of Tokushima, School of Dentistry, Research Associate, 歯学部, 助手 (90294701)
HANEJI Norio  The University of Tokushima, School of Dentistry, Research Associate, 歯学部, 助手 (30274228)
Project Period (FY) 1996 – 1998
KeywordsSjogren syndrome / Animal model / NFS / sld mouse / Autoantigen / Autoreactive T cells / T cell epitope / B cell epitope / alpha-fodrin
Research Abstract

Primary Sjogren syndrome (SS) in humans is an autoimmune disease characterized by diffuse lymphoid cell infiltrates in the salivary and lacrimal glands, resulting in symptoms of dry mouth and dry eye clue to insufficient secretion. The spectrum of presentation of the disease is broad, ranging from the organ-localized dysfunction of exocrine gland to systemic complications such as liver, kidney and lung involvement. Moreover, a significant proportion of the SS patients may develop malignant lymphoproloferative disorders such as B cell lymphoma and macroglobulinemia. Although it has been assumed that a combination of immunologic, genetic, and environmental factors may play a key role on the development of autoimmune lesion in the salivary and lacrimal gland, little is known about the disease pathogenesis of primary SS in humans. A great interest is to investigate different immunological aspects of human autoimmune diseases including SS.The hypofunction of the salivary glands is due to lymphocytic infiltration, in which it is generally assumed that autoreactive T cells recognize unknown self-antigen and play a central role in the pathogenesis of SS.Primary SS is also characterized by systemic production of autoantibodies to ribonucleoprotein (RNP) particles SS-A/Ro and SS-B/ La, but the specificity for the immunogenicity of SS-A and SS-B remains unclear. Although it has been unclear whether or not there are critical organ-specific autoantigen(s) relevant to human primary SS, we have recently identified the 120KD alpha-fodrin as an important salivary gland autoantigen on the development of SS in both animal model and SS patients.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] N.Haneji et al: "Identification of α-fodrin as a candidate autoantigen in primary Sjogren's syndrome." Science. 276. 604-607 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Azuma et al: "Role of cytokines of acinar structure in Sjogren's syndrome salivary glands." Lab.Invest.77(3). 269-280 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Yaagi et al: "Anti-120-kDa α-fodrin immune response with Th-1-cytokine profile in the NOD mouse model of Sjogren's syndrome." Eur.J.Immunol.28. 3336-3345 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Tsubota et al: "Use of topical cyclosporin A in a primary Sjogren's syndrome mouse model." Invest.Ophthalmol.Vis.Sci.39. 1551-1559 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Miyagawa et al: "Neonatal lupus erythematosus:Maternal IgG antibodies bind to a recombinant NH2-terminal fusion protein encoded by human α-fodrin cDNA." J.Invest.Dermatol.111. 1189-1192 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Hayashi: "The immunology of Sjogren's syndrome:emphasis on the role of salivary gland autoantigen." Biomedical Reviews. in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Haneji et al.: "Identification of alpha-fodrin as a candidate autoantigen in primary Sjogren's syndrome." Science. 276. 604-607 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Azuma et al.: "Role of cytokines of acinar structure in Sjogren's syndrome salivary glands." Lab. Invest.77 (3). 269-280 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Yanagi et al.: "Anti-120-kDa alpha-fodrin immune response with Th-1-cytokine profile in the NOD mouse model of Sjogren's syndrome" Eur. J.Immunol. 28. 3336-3345 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tsubota et al.: "Use of topical cyc1osporin A in a primary Sjogren's syndrome mouse model." Invest. Ophthalmol. Vis. Sci.39. 1551-1559 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Miyagawa et al.: "Neonatal lupus erythematosus : Maternal IgG antibodies bind to a recombinant NH2-terminal fusion protein encoded by human alpha-fodrin cDNA." J.Invest. Dermatol.111. 1189-1192 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Hayashi: "The immunology of Sjogren's syndrome : emphasis on the role of salivary gland autoantigen." Biomedical Reviews. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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