1997 Fiscal Year Final Research Report Summary
SYNTHESIS OF RECEPTOR MOLECULES VIA NEW CHEMICAL METHODS
| Project/Area Number |
08454205
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
TSUKUBE Hiroshi OSAKA CITY UNIVERSITY,FACULTY OF SCIENCE,PROFESSOR, 理学部, 教授 (00144725)
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| Co-Investigator(Kenkyū-buntansha) |
SHINODA Satoshi OSAKA CITY UNIVERSITY,FACULTY OF SCIENCE,RESEARCH ASSOCIATE, 理学部, 助手 (00285280)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Ion Recognition / Computer Chemistry / Biocatalyst / Armed Cyclen / Anion receptor |
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| Research Abstract |
Since "molecular recognition" plays important roles in biomembrane transport, enzymatic reactions, and other biological processes, synthesis of specific receptors is one of the most exciting subjects in current chemistry. They offer excellent opportunities in investigating biological functions and developing supermolecular devices.
Although many kinds of artificial receptors have been presented, their design and synthesis are "trial-and-error" exercises. We developed in this project non-empirical design and highly efficient synthesis of specific receptors as summarized below :
(1)Computational Design of Cation-Specific Receptor : We optimized Na^+ ion-specific armed macrocycles by computational modeling.
(2)Efficient Synthesis of Chiral Pyridine Podands : A combined synthesis with biocatalysts and organometallics offered a new series of chiral oligopyridine ligands in excellent yields.
(3)One-Step Synthesis of Anion-Specific Receptors : A new type of macrocycle containing four pyridinium cations was readily prepared, which exhibited highly selective anion binding functions.
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